Long COVID: neurological manifestations - an updated narrative review
Dementia & Neuropsychologia,
Год журнала:
2024,
Номер
18
Опубликована: Янв. 1, 2024
ABSTRACT.
Infection
with
the
SARS-CoV-2
virus
can
lead
to
neurological
symptoms
in
acute
phase
and
Long
COVID
phase.
These
usually
involve
cognition,
sleep,
smell
disorders,
psychiatric
manifestations,
headache
others.
This
condition
is
more
commonly
described
young
adults
women.
symptomatology
follow
severe
or
mild
cases
of
disease.
The
importance
this
issue
resides
high
prevalence
phase,
which
entails
significant
morbidity
population.
In
addition,
such
a
associated
health
care
costs,
some
estimates
hovering
around
3.7
trillion
US
dollars.
review,
we
will
sequentially
describe
current
knowledge
about
most
prevalent
COVID,
as
well
their
pathophysiology
possible
biomarkers.
Язык: Английский
Objectifying persistent subjective cognitive impairment following COVID-19 infection: cross-sectional data from an outpatient memory-clinic in Germany
European Archives of Psychiatry and Clinical Neuroscience,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 28, 2025
Abstract
Objective
Subjective
cognitive
impairment
is
frequently
reported
by
patients
experiencing
Post-COVID
symptoms.
This
study
aims
to
assess
objective
in
attention,
memory,
and
executive
functions
among
these
patients.
Further,
we
investigated
potential
determinants
of
impairment.
Methods
In
this
cross-sectional
study,
standardized
neuropsychological
testing
(Vienna
Testing
System),
assessment
symptom
aggravation,
psychiatric
anamnesis,
psychometrics
(BDI-II,
Fatigue
Severity
Scale)
were
conducted
229
who
voluntarily
presented
our
outpatient
memory-clinic
due
subjective
following
COVID-19.
Blood-samples
collected
peripheral
immune
markers
(IL-6,
CRP)
APOE-ε4
genotype.
Results
at
least
one
domain
was
present
39%
the
47%
showed
symptoms
moderate
or
severe
depression.
The
APOE
-ε4
allele
32%
Higher
rates
depressive
(OR
=
1.41,
95%-CI
1.02–1.95)
higher
burden
3.29,
1.51–7.40)
predicted
impairment,
regardless
age,
sex,
years
formal
education,
time
since
infection,
medication
for
diabetes
hypertension.
severity,
acute
COVID-19
severity
inflammation
had
no
impact.
Conclusions
more
likely
associated
with
high
depression
rather
than
relatively
low
performance.
Thus,
emphasizes
necessity
extensive
evaluation
when
examining
clinical
practice.
link
between
does
not
appear
be
specific
Therefore,
depression-
APOE-ε4-mediated
neurodegenerative
pathomechanisms
might
a
promising
therapeutical
target.
Язык: Английский
The Clinical Aspects of COVID and Alzheimer’s Disease: A Round-Up of Where Things Stand and Are Headed
Journal of Alzheimer s Disease,
Год журнала:
2024,
Номер
99(4), С. 1159 - 1171
Опубликована: Июнь 7, 2024
The
link
between
long
COVID-19
and
brain/cognitive
impairments
is
concerning
may
foster
a
worrisome
worldwide
emergence
of
novel
cases
neurodegenerative
diseases
with
aging.
This
review
aims
to
update
the
knowledge,
crosstalk,
possible
intersections
Post-COVID
Syndrome
(PCS)
Alzheimer’s
disease
(AD).
References
included
in
this
were
obtained
from
PubMed
searches
conducted
October
2023
November
2023.
PCS
very
heterogenous
poorly
understood
recent
evidence
association
chronic
such
as
AD.
However,
more
scientific
data
required
establish
Язык: Английский
Neurological, psychological, psychosocial complications of long-COVID and their management
Neurological Sciences,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 9, 2024
Since
it
first
appeared,
Severe
Acute
Respiratory
Syndrome
Coronavirus
2
(SARS-CoV-2)
has
had
a
significant
and
lasting
negative
impact
on
the
health
economies
of
millions
individuals
all
over
globe.
At
level
individual
too,
many
patients
are
not
recovering
fully
experiencing
long-term
condition
now
commonly
termed
'long-COVID'.
Long-COVID
is
collection
symptoms
which
must
last
more
than
12
weeks
following
initial
COVID
infection,
cannot
be
adequately
explained
by
alternate
diagnoses.
The
neurological
psychosocial
long-COVID
itself
global
crisis
therefore
preventing,
diagnosing,
managing
these
paramount
importance.
This
review
focuses
primarily
on:
functioning
deficits;
mental
impacts;
mood
problems;
associated
issues,
among
suffering
from
with
an
eye
towards
basis
symptoms.
A
concise
account
clinical
relevance
impacts
long-COVID,
effects
morbidity,
varied
approaches
in
chronic
conditions
was
extracted
literature,
analysed
reported.
comprehensive
plausible
pathophysiological
mechanisms
involved
development
its
management,
future
research
needs
have
been
discussed.
Язык: Английский