Neurological, psychological, psychosocial complications of long-COVID and their management DOI Creative Commons
Sareesh Naduvil Narayanan,

Sreeshma Padiyath,

Krishnapriya Chandrababu

et al.

Neurological Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 9, 2024

Since it first appeared, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has had a significant and lasting negative impact on the health economies of millions individuals all over globe. At level individual too, many patients are not recovering fully experiencing long-term condition now commonly termed 'long-COVID'. Long-COVID is collection symptoms which must last more than 12 weeks following initial COVID infection, cannot be adequately explained by alternate diagnoses. The neurological psychosocial long-COVID itself global crisis therefore preventing, diagnosing, managing these paramount importance. This review focuses primarily on: functioning deficits; mental impacts; mood problems; associated issues, among suffering from with an eye towards basis symptoms. A concise account clinical relevance impacts long-COVID, effects morbidity, varied approaches in chronic conditions was extracted literature, analysed reported. comprehensive plausible pathophysiological mechanisms involved development its management, future research needs have been discussed.

Language: Английский

Long COVID: neurological manifestations - an updated narrative review DOI Creative Commons
José Wagner Leonel Tavares-Júnior, Gabriella Cunha Vieira Ciurleo, Alissa Moura Formiga

et al.

Dementia & Neuropsychologia, Journal Year: 2024, Volume and Issue: 18

Published: Jan. 1, 2024

ABSTRACT. Infection with the SARS-CoV-2 virus can lead to neurological symptoms in acute phase and Long COVID phase. These usually involve cognition, sleep, smell disorders, psychiatric manifestations, headache others. This condition is more commonly described young adults women. symptomatology follow severe or mild cases of disease. The importance this issue resides high prevalence phase, which entails significant morbidity population. In addition, such a associated health care costs, some estimates hovering around 3.7 trillion US dollars. review, we will sequentially describe current knowledge about most prevalent COVID, as well their pathophysiology possible biomarkers.

Language: Английский

Citations

5
Objectifying persistent subjective cognitive impairment following COVID-19 infection: cross-sectional data from an outpatient memory-clinic in Germany DOI Creative Commons

Luca Tarantini,

Corina Möller, Corina Möller

et al.

European Archives of Psychiatry and Clinical Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Abstract Objective Subjective cognitive impairment is frequently reported by patients experiencing Post-COVID symptoms. This study aims to assess objective in attention, memory, and executive functions among these patients. Further, we investigated potential determinants of impairment. Methods In this cross-sectional study, standardized neuropsychological testing (Vienna Testing System), assessment symptom aggravation, psychiatric anamnesis, psychometrics (BDI-II, Fatigue Severity Scale) were conducted 229 who voluntarily presented our outpatient memory-clinic due subjective following COVID-19. Blood-samples collected peripheral immune markers (IL-6, CRP) APOE-ε4 genotype. Results at least one domain was present 39% the 47% showed symptoms moderate or severe depression. The APOE -ε4 allele 32% Higher rates depressive (OR = 1.41, 95%-CI 1.02–1.95) higher burden 3.29, 1.51–7.40) predicted impairment, regardless age, sex, years formal education, time since infection, medication for diabetes hypertension. severity, acute COVID-19 severity inflammation had no impact. Conclusions more likely associated with high depression rather than relatively low performance. Thus, emphasizes necessity extensive evaluation when examining clinical practice. link between does not appear be specific Therefore, depression- APOE-ε4-mediated neurodegenerative pathomechanisms might a promising therapeutical target.

Language: Английский

Citations

0
The Clinical Aspects of COVID and Alzheimer’s Disease: A Round-Up of Where Things Stand and Are Headed DOI
José Wagner Leonel Tavares-Júnior, Gabriella Cunha Vieira Ciurleo, Esther de Alencar Araripe Falcão Feitosa

et al.

Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: 99(4), P. 1159 - 1171

Published: June 7, 2024

The link between long COVID-19 and brain/cognitive impairments is concerning may foster a worrisome worldwide emergence of novel cases neurodegenerative diseases with aging. This review aims to update the knowledge, crosstalk, possible intersections Post-COVID Syndrome (PCS) Alzheimer’s disease (AD). References included in this were obtained from PubMed searches conducted October 2023 November 2023. PCS very heterogenous poorly understood recent evidence association chronic such as AD. However, more scientific data required establish

Language: Английский

Citations

1
Neurological, psychological, psychosocial complications of long-COVID and their management DOI Creative Commons
Sareesh Naduvil Narayanan,

Sreeshma Padiyath,

Krishnapriya Chandrababu

et al.

Neurological Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 9, 2024

Since it first appeared, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has had a significant and lasting negative impact on the health economies of millions individuals all over globe. At level individual too, many patients are not recovering fully experiencing long-term condition now commonly termed 'long-COVID'. Long-COVID is collection symptoms which must last more than 12 weeks following initial COVID infection, cannot be adequately explained by alternate diagnoses. The neurological psychosocial long-COVID itself global crisis therefore preventing, diagnosing, managing these paramount importance. This review focuses primarily on: functioning deficits; mental impacts; mood problems; associated issues, among suffering from with an eye towards basis symptoms. A concise account clinical relevance impacts long-COVID, effects morbidity, varied approaches in chronic conditions was extracted literature, analysed reported. comprehensive plausible pathophysiological mechanisms involved development its management, future research needs have been discussed.

Language: Английский

Citations

1