Unraveling the Complexity of Human Brain: Structure, Function in Healthy and Disease States
Ageing Research Reviews,
Год журнала:
2024,
Номер
100, С. 102414 - 102414
Опубликована: Июль 14, 2024
Язык: Английский
Epigenetic Mechanisms Underlying Sex Differences in Neurodegenerative Diseases
Biology,
Год журнала:
2025,
Номер
14(1), С. 98 - 98
Опубликована: Янв. 19, 2025
Neurodegenerative
diseases
are
characterized
by
profound
differences
between
females
and
males
in
terms
of
incidence,
clinical
presentation,
disease
progression.
Furthermore,
there
is
evidence
suggesting
that
sensitivity
to
medical
treatments
may
exist
the
two
sexes.
Although
role
sex
hormones
chromosomes
driving
differential
susceptibility
these
well-established,
molecular
alterations
underlying
remain
poorly
understood.
Epigenetic
mechanisms,
including
DNA
methylation,
histone
tail
modifications,
activity
non-coding
RNAs,
strongly
implicated
pathogenesis
neurodegenerative
diseases.
While
it
known
epigenetic
mechanisms
play
a
crucial
sexual
differentiation
distinct
patterns
characterize
males,
sex-specific
have
been
largely
overlooked
studies
aiming
identify
associated
with
This
review
aims
provide
an
overview
processes
central
nervous
system,
main
three
diseases,
Alzheimer’s
disease,
Parkinson’s
amyotrophic
lateral
sclerosis.
Understanding
sex-related
essential
for
developing
personalized
interventions
account
unique
landscapes
each
sex.
Язык: Английский
Advances in glial cell line-derived neurotrophic factor
Deleted Journal,
Год журнала:
2024,
Номер
unknown, С. 1 - 12
Опубликована: Окт. 10, 2024
Glial
cell
line-derived
neurotrophic
factor
(GDNF)
is
a
potent
with
significant
research
value
due
to
its
profound
effects
on
dopaminergic,
cholinergic,
and
motor
neurons.
Initially
identified
for
neuroprotective
role
in
dopaminergic
neurons,
GDNF
has
been
found
support
various
neuronal
populations
plays
crucial
neural
development,
maintenance,
repair.
This
review
provides
comprehensive
overview
of
the
molecular
characteristics,
tissue
distribution,
physiological
function
protective
effect
series
diseases,
emphasizing
potential
therapeutic
applications.
Meanwhile,
this
study
discusses
challenges
delivering
across
blood-brain
barrier
explores
current
strategies
enhance
clinical
efficacy,
including
use
gene
therapy
innovative
delivery
methods.
In
summary,
underscores
promise
as
agent
neurodegenerative
diseases
nerve
injuries,
highlighting
need
further
translate
these
findings
into
practice.
Язык: Английский