Unraveling the Complexity of Human Brain: Structure, Function in Healthy and Disease States
Ageing Research Reviews,
Journal Year:
2024,
Volume and Issue:
100, P. 102414 - 102414
Published: July 14, 2024
Language: Английский
Epigenetic Mechanisms Underlying Sex Differences in Neurodegenerative Diseases
Biology,
Journal Year:
2025,
Volume and Issue:
14(1), P. 98 - 98
Published: Jan. 19, 2025
Neurodegenerative
diseases
are
characterized
by
profound
differences
between
females
and
males
in
terms
of
incidence,
clinical
presentation,
disease
progression.
Furthermore,
there
is
evidence
suggesting
that
sensitivity
to
medical
treatments
may
exist
the
two
sexes.
Although
role
sex
hormones
chromosomes
driving
differential
susceptibility
these
well-established,
molecular
alterations
underlying
remain
poorly
understood.
Epigenetic
mechanisms,
including
DNA
methylation,
histone
tail
modifications,
activity
non-coding
RNAs,
strongly
implicated
pathogenesis
neurodegenerative
diseases.
While
it
known
epigenetic
mechanisms
play
a
crucial
sexual
differentiation
distinct
patterns
characterize
males,
sex-specific
have
been
largely
overlooked
studies
aiming
identify
associated
with
This
review
aims
provide
an
overview
processes
central
nervous
system,
main
three
diseases,
Alzheimer’s
disease,
Parkinson’s
amyotrophic
lateral
sclerosis.
Understanding
sex-related
essential
for
developing
personalized
interventions
account
unique
landscapes
each
sex.
Language: Английский
HR-MS Analysis of the Covalent Binding of Edaravone to 5-Formylpyrimidine Bases and a DNA Oligonucleotide Containing a 5-Formylcytidine Residue.
PubMed,
Journal Year:
2025,
Volume and Issue:
39(14), P. e10050 - e10050
Published: July 30, 2025
Edaravone
(EDA)
is
a
radical
scavenger
and
an
antioxidant
drug
approved
to
treat
amyotrophic
lateral
sclerosis
used
as
research
tool
explore
treatment
of
neurodegenerative
diseases
cancers.
It
also
reactive
agent,
known
PMP
(1-phenyl-3-methyl-5-pyrazolone),
for
the
analysis
polysaccharides
composition.
EDA
can
react
with
sugars
aromatic
aldehydes.
In
this
context,
we
have
investigated
reactivity
toward
biologically
relevant
formylated
nucleobases,
nucleosides,
oligonucleotide
containing
residue.
The
formation
both
mono-
bis-adducts
between
nucleobases
(5-formyluracil
(5fU)
5-formylcytosine
(5fC))
or
corresponding
nucleosides
5-fdU
5-fdC
was
characterized
using
high-resolution
mass
spectrometry
(HR-MS).
Similarly,
covalent
binding
8-mer
palindromic
d
(TATG[*C]ATA)
single
residue
[*C]
under
physiological
conditions
spectrometry.
For
first
time,
shown
pyrimidines.
Covalent
stable
adducts
were
identified.
found
efficiently
generate
bis-adducts.
rate
mono-adduct
five
times
higher
than
that
bis-adduct.
reaction
aldehydic
DNA
modifications
such
5fU/5fC
may
important
consequences
in
terms
gene
expression.
These
observations
raise
implications
epigenetic
contribution
mechanism
action
EDA.
biological
our
vitro
results
are
discussed,
notably
frame
Language: Английский
Advances in glial cell line-derived neurotrophic factor
Jin Yang
No information about this author
Deleted Journal,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 12
Published: Oct. 10, 2024
Glial
cell
line-derived
neurotrophic
factor
(GDNF)
is
a
potent
with
significant
research
value
due
to
its
profound
effects
on
dopaminergic,
cholinergic,
and
motor
neurons.
Initially
identified
for
neuroprotective
role
in
dopaminergic
neurons,
GDNF
has
been
found
support
various
neuronal
populations
plays
crucial
neural
development,
maintenance,
repair.
This
review
provides
comprehensive
overview
of
the
molecular
characteristics,
tissue
distribution,
physiological
function
protective
effect
series
diseases,
emphasizing
potential
therapeutic
applications.
Meanwhile,
this
study
discusses
challenges
delivering
across
blood-brain
barrier
explores
current
strategies
enhance
clinical
efficacy,
including
use
gene
therapy
innovative
delivery
methods.
In
summary,
underscores
promise
as
agent
neurodegenerative
diseases
nerve
injuries,
highlighting
need
further
translate
these
findings
into
practice.
Language: Английский