The roles of macrophage polarization in the host immune response to sepsis

International Immunopharmacology, Год журнала: 2021, Номер 96, С. 107791 - 107791

Опубликована: Май 29, 2021

Язык: Английский

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Pyroptosis, a new bridge to tumor immunity

Cancer Science, Год журнала: 2021, Номер 112(10), С. 3979 - 3994

Опубликована: Июль 12, 2021

Pyroptosis refers to the process of gasdermin (GSDM)-mediated programmed cell death (PCD). Our understanding pyroptosis has expanded beyond cells and is known involve extracellular responses. Recently, there been an increasing interest in due its emerging role activating immune system. In meantime, pyroptosis-mediated therapies, which use response kill cancer cells, have also achieved notable success a clinical setting. this review, we discuss that induced by activation double-edged sword affects all stages tumorigenesis. On one hand, inflammasome-mediated release pyroptosis-produced cytokines alter microenvironment promote development tumors evading surveillance. other can collect ignite system improve efficiency tumor immunotherapies. related some checkpoints, especially death-1 (PD-1) or death- ligand 1 (PD-L1). mainly focus on our current interplay between through pyroptosis, debate their as potential therapeutic targets.

Язык: Английский

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The Role of NLRP3 Inflammasome in Cerebrovascular Diseases Pathology and Possible Therapeutic Targets

ASN NEURO, Год журнала: 2021, Номер 13, С. 175909142110181 - 175909142110181

Опубликована: Янв. 1, 2021

Cerebrovascular diseases are pathological conditions involving impaired blood flow in the brain, primarily including ischaemic stroke, intracranial haemorrhage, and subarachnoid haemorrhage. The nucleotide-binding oligomerisation (NOD) domain-like receptor (NLR) family pyrin domain (PYD)-containing 3 (NLRP3) inflammasome is a protein complex vital component of immune system. Emerging evidence has indicated that NLRP3 plays an important role cerebrovascular diseases. function pathogenesis remains interesting field research. In this review, we first summarised mechanism aggravating atherosclerosis Second, outlined signalling pathways through which participates or mitigating Reactive oxygen species (ROS)/nuclear factor kappa-light-chain-enhancer activated B cells (NF-κB), ROS/thioredoxin-interacting (TXNIP) purinergic receptor-7 (P2X7R) can activate inflammasome; activation aggravate by mediating apoptosis pyroptosis. Autophagy/mitochondrial autophagy, nuclear E2-related factor-2 (Nrf2), interferon (IFN)-β, sirtuin (SIRT), phosphoinositide 3-kinase (PI3K)/protein kinase (AKT) reportedly alleviate inhibiting activation. Finally, explored specific inhibitors based on two-step inflammasome, be developed as new drugs to treat

Язык: Английский

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Drug delivery strategy in hepatocellular carcinoma therapy

Cell Communication and Signaling, Год журнала: 2022, Номер 20(1)

Опубликована: Март 5, 2022

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide, with high rates recurrence and death. Surgical resection ablation therapy have limited efficacy for patients advanced HCC poor liver function, so pharmacotherapy first-line option those patients. Traditional antitumor drugs disadvantages biological distribution pharmacokinetics, target selectivity, resistance, toxicity to nontargeted tissues. Recently, development nanotechnology has significantly improved drug delivery tumor sites by changing physical characteristics nanocarriers improve their pharmacokinetics selectively accumulate cytotoxic agents at sites. Here, we systematically review microenvironment recent application in HCC. Video Abstract.

Язык: Английский

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Apigenin Inhibits the Progression of Osteoarthritis by Mediating Macrophage Polarization

Molecules, Год журнала: 2023, Номер 28(7), С. 2915 - 2915

Опубликована: Март 24, 2023

The overall purpose of this study was to investigate the mechanism macrophage polarization on chondrocyte injury in osteoarthritis and protective effect apigenin chondrocytes osteoarthritis.Primary were isolated from knee cartilage three-day-old mice, cells positive for Alsine blue staining type II collagen immunocytochemical identified used followup experiments. Transwell coculture performed. Chondrocytes inoculated inferior compartment, macrophages upper compartment. experimental groups N group, LPS LPS+ group. inflammation verified by drug administration. Real-time quantitative PCR (qPCR) Western blot detect expression RNA protein. Experimental OA induced modified Hulth surgery mice. Modified performed mouse's right induce with nonoperative serving as an ipsilateral control. mice randomly assigned three (six per group): sham + Animals given gavage four weeks. articular histological immunohistochemical analysis.Histological showed that had a degeneration surgery. results significantly reduced levels IL-1, IL-6, MMP3, MMP13 it cartilage. Apigenin TNF-α, IL-12 increased MG-L1, MG-L2, ARG-1, IL-10, which can inhibit M1 promote M2 polarization. In system, decreased protein TRPM7, P-mTOR, BAX, c-caspase3 macrophages, while increasing Bcl2. MMP13, P38, JNK, ERK phosphorylation chondrocytes.Apigenin alleviates Hulth. inhibits through MAPK pathway. macrophage-polarization-induced inflammatory response apoptosis macrophage-chondrocyte system TRPM7-mTOR

Язык: Английский

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Molecular mechanisms of pyroptosis and its role in anti-tumor immunity

International Journal of Biological Sciences, Год журнала: 2023, Номер 19(13), С. 4166 - 4180

Опубликована: Янв. 1, 2023

Pyroptosis is a form of cell death that characterized by the destruction cell, and it has implications in both immune system cancer immunotherapy.The gasdermin family responsible for activation pyroptosis, which involves formation pores cellular membrane permit discharge inflammatory factors.The inflammasome response powerful mechanism helps to eliminate bacteria cells when damage occurs.As tumor become more resilient apoptosis, other treatments are becoming popular.It essential gain thorough understanding pyroptosis order use treatment, considering intricate association between system's defensive reaction against tumors.This review offers an overview mechanisms relationship interplay anti-tumor immunity.In addition, potential immunotherapy discussed.Additionally, we explore future research possibilities introduce novel approach treatment.

Язык: Английский

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IRG1/itaconate alleviates acute liver injury in septic mice by suppressing NLRP3 expression and its mediated macrophage pyroptosis via regulation of the Nrf2 pathway

International Immunopharmacology, Год журнала: 2024, Номер 135, С. 112277 - 112277

Опубликована: Май 23, 2024

Язык: Английский

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Natural Products with Activity against Lung Cancer: A Review Focusing on the Tumor Microenvironment

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(19), С. 10827 - 10827

Опубликована: Окт. 7, 2021

Lung cancer is one of the most prevalent malignancies worldwide. Despite undeniable progress in lung research made over past decade, it still leading cause cancer-related deaths and continues to challenge scientists researchers engaged searching for therapeutics drugs. The tumor microenvironment (TME) recognized as major hallmarks epithelial cancers, including majority associated with tumorigenesis, progression, invasion, metastasis. Targeting TME has received increasing attention recent years. Natural products have historically substantial contributions pharmacotherapy, especially cancer. In this review, we emphasize role summarize experimental proof demonstrating antitumor effects underlying mechanisms natural that target TME. We also review used combination anticancer agents. Moreover, highlight nanotechnology other materials enhance products. Overall, our hope these will encourage more thoughts ideas on therapeutic development benefit patients.

Язык: Английский

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Pyroptosis, a target for cancer treatment?

APOPTOSIS, Год журнала: 2022, Номер 27(1-2), С. 1 - 13

Опубликована: Янв. 22, 2022

Язык: Английский

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Ferroptosis, pyroptosis and necroptosis in hepatocellular carcinoma immunotherapy: Mechanisms and immunologic landscape (Review)

International Journal of Oncology, Год журнала: 2024, Номер 64(6)

Опубликована: Май 9, 2024

Hepatocellular carcinoma (HCC), one of the leading causes cancer‑related mortality worldwide, is challenging to identify in its early stages and prone metastasis, prognosis patients with this disease poor. Treatment options for HCC are limited, even radical treatments being associated a risk recurrence or transformation short term. Furthermore, multi‑tyrosine kinase inhibitors approved first‑line therapy have marked drawbacks, including drug resistance side effects. The rise breakthrough immune checkpoint (ICIs) provided novel direction immunotherapy but these drawback low response rates. Since avoiding apoptosis universal feature cancer, induction non‑apoptotic regulatory cell death (NARCD) strategy immunotherapy. At present, NARCD pathways, ferroptosis, pyroptosis necroptosis, potential forms immunogenic death, which synergistic effects antitumor immunity, transforming 'cold' tumors into 'hot' exerting Therefore, pathways may be targeted as treatment HCC. In present review, roles necroptosis immunity discussed, relevant targets signaling current status combined ICIs summarized. prospects targeting also considered.

Язык: Английский

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