Mini-Reviews in Medicinal Chemistry,
Год журнала:
2024,
Номер
24(21), С. 1953 - 1969
Опубликована: Апрель 19, 2024
:
Glioblastoma
multiforme
(GBM),
a
solid
tumor
that
develops
from
astrocytes,
is
one
of
the
most
aggressive
types
brain
cancer.
While
there
have
been
improvements
in
efficacy
treating
GBM,
many
problems
remain,
especially
with
traditional
therapy
methods.
Therefore,
recent
studies
extensively
focused
on
developing
novel
therapeutic
agents
for
combating
glioblastoma.
Natural
polyphenols
studied
their
potential
as
chemopreventive
and
chemotherapeutic
due
to
wide
range
positive
qualities,
including
antioxidant,
antiinflammatory,
cytotoxic,
antineoplastic,
immunomodulatory
activities.
These
natural
compounds
suggested
act
via
modulated
various
macromolecules
within
cells,
microRNAs
(miRNAs),
which
play
crucial
role
molecular
milieu.
In
this
article,
we
focus
how
may
inhibit
growth
by
influencing
expression
key
miRNAs
regulate
oncogenes
suppressor
genes
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(5), С. 2529 - 2529
Опубликована: Фев. 21, 2024
Glioblastoma
(GB)
stands
out
as
the
most
prevalent
and
lethal
form
of
brain
cancer.
Although
great
efforts
have
been
made
by
clinicians
researchers,
no
significant
improvement
in
survival
has
achieved
since
Stupp
protocol
became
standard
care
(SOC)
2005.
Despite
multimodality
treatments,
recurrence
is
almost
universal
with
rates
under
2
years
after
diagnosis.
Here,
we
discuss
recent
progress
our
understanding
GB
pathophysiology,
particular,
importance
glioma
stem
cells
(GSCs),
tumor
microenvironment
conditions,
epigenetic
mechanisms
involved
growth,
aggressiveness
recurrence.
The
discussion
on
therapeutic
strategies
first
covers
SOC
treatment
targeted
therapies
that
shown
to
interfere
different
signaling
pathways
(pRB/CDK4/RB1/P16
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(14), С. 7603 - 7603
Опубликована: Июль 11, 2024
This
article
presents
a
groundbreaking
perspective
on
carotenoids,
focusing
their
innovative
applications
and
transformative
potential
in
human
health
medicine.
Research
jointly
delves
deeper
into
the
bioactivity
bioavailability
of
revealing
therapeutic
uses
technological
advances
that
have
to
revolutionize
medical
treatments.
We
explore
pioneering
which
carotenoids
are
used
treat
chronic
diseases
such
as
cancer,
cardiovascular
disease,
age-related
macular
degeneration,
offering
novel
protective
mechanisms
benefits.
Our
study
also
shows
cutting-edge
innovations
carotenoid
extraction
bioavailability,
including
development
supramolecular
carriers
advanced
nanotechnology,
dramatically
improve
absorption
efficacy
these
compounds.
These
not
only
ensure
consistent
quality
but
tailor
therapies
each
patient's
needs,
paving
way
for
personalized
By
integrating
latest
scientific
discoveries
techniques,
this
research
provides
prospective
clinical
establishing
new
benchmark
future
studies
field.
findings
underscore
importance
optimizing
extraction,
administration,
bioactivity,
methods
develop
more
effective,
targeted,
treatments,
thus
visionary
insight
modern
practices.
Biomolecules,
Год журнала:
2021,
Номер
11(12), С. 1841 - 1841
Опубликована: Дек. 7, 2021
Flavonoids
are
polyphenolic
plant
secondary
metabolites
with
pleiotropic
biological
properties,
including
anti-cancer
activities.
These
natural
compounds
have
potential
utility
in
glioblastoma
(GBM),
a
malignant
central
nervous
system
tumor
derived
from
astrocytes.
Conventional
GBM
treatment
modalities
such
as
chemotherapy,
radiation
therapy,
and
surgical
resection
beneficial
but
limited
by
extensive
invasion
drug/radiation
resistance.
Therefore,
dietary
flavonoids-with
demonstrated
anti-GBM
properties
preclinical
research-are
alternative
therapies.
This
review
explores
the
synergistic
enhancement
of
effects
conventional
chemotherapeutic
drugs
flavonoids.
Primary
studies
published
between
2011
2021
on
flavonoid-chemotherapeutic
synergy
were
obtained
PubMed.
demonstrate
that
flavonoids
chrysin,
epigallocatechin-3-gallate
(EGCG),
formononetin,
hispidulin,
icariin,
quercetin,
rutin,
silibinin
synergistically
enhance
canonical
chemotherapeutics.
mediated
modulation
intracellular
signaling
mechanisms
related
to
apoptosis,
proliferation,
autophagy,
motility,
chemoresistance.
In
this
light,
hold
promise
improving
current
therapeutic
strategies
ultimately
overcoming
drug
However,
despite
positive
results,
further
investigations
necessary
before
commencement
clinical
trials.
Key
considerations
include
bioavailability,
blood-brain
barrier
(BBB)
permeability,
safety
flavonoids;
optimal
dosages
chemotherapeutics;
delivery
platforms;
for
adverse
interactions.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(6), С. 3360 - 3360
Опубликована: Март 20, 2022
In
humans,
glioblastoma
is
the
most
prevalent
primary
malignant
brain
tumor.
Usually,
has
specific
characteristics,
such
as
aggressive
cell
proliferation
and
rapid
invasion
of
surrounding
tissue,
leading
to
a
poor
patient
prognosis.
The
current
therapy—which
provides
multidisciplinary
approach
with
surgery
followed
by
radiotherapy
chemotherapy
temozolomide—is
not
very
efficient
since
it
faces
clinical
challenges
tumor
heterogeneity,
invasiveness,
chemoresistance.
this
respect,
natural
substances
in
diet,
integral
components
lifestyle
medicine
approach,
can
be
seen
potential
chemotherapeutics.
There
are
several
epidemiological
studies
that
have
shown
chemopreventive
role
dietary
compounds
cancer
progression
development.
These
heterogeneous
produce
anti-glioblastoma
effects
through
upregulation
apoptosis
autophagy;
allowing
promotion
cycle
arrest;
interfering
metabolism;
permitting
proliferation,
neuroinflammation,
chemoresistance,
angiogenesis,
metastasis
inhibition.
Although
these
beneficial
promising,
efficacy
limited
due
their
bioavailability
blood–brain
barrier
permeability.
Thereby,
further
trials
necessary
confirm
vitro
vivo
anticancer
properties
compounds.
article,
we
overview
treatment
considering
overcome
future
prospects.
Nanomaterials,
Год журнала:
2022,
Номер
12(2), С. 238 - 238
Опубликована: Янв. 12, 2022
Phytopharmaceuticals
have
been
widely
used
globally
since
ancient
times
and
acknowledged
by
healthcare
professionals
patients
for
their
superior
therapeutic
value
fewer
side-effects
compared
to
modern
medicines.
However,
phytopharmaceuticals
need
a
scientific
methodical
approach
deliver
components
thereby
improve
patient
compliance
treatment
adherence.
Dose
reduction,
improved
bioavailability,
receptor
selective
binding,
targeted
delivery
of
can
be
likely
achieved
molding
them
into
specific
nano-formulations.
In
recent
decades,
nanotechnology-based
emerged
as
potential
candidates
the
various
communicable
non-communicable
diseases.
Nanotechnology
combined
with
broadens
perspective
overcomes
problems
associated
plant
medicine.
The
current
review
highlights
application
nano-phytopharmaceuticals
in
neurological,
cardiovascular,
pulmonary,
gastro-intestinal
disorders.
We
conclude
that
emerge
promising
therapeutics
many
pathological
conditions
good
higher
acceptance.
Plants,
Год журнала:
2023,
Номер
12(11), С. 2126 - 2126
Опубликована: Май 27, 2023
A
balanced
diet,
rich
in
fruits
and
vegetables
ensuring
the
intake
of
natural
products,
has
been
shown
to
reduce
or
prevent
occurrence
many
chronic
diseases.
However,
choice
consume
large
quantities
leads
an
increase
amount
waste,
which
can
cause
alteration
environmental
sustainability.
To
date,
concept
a
"byproduct"
evolved,
now
being
understood
as
waste
product
from
it
is
still
possible
obtain
useful
compounds.
Byproducts
agricultural
sector
are
source
bioactive
compounds,
capable
possessing
second
life,
decreasing
disposal
costs,
pollution.
promising
well-known
citrus
Mediterranean
diet
bergamot
(Citrus
bergamia,
Risso
et
Poiteau).
The
composition
known,
presence
phenolic
compounds
essential
oils
justified
countless
beneficial
properties
found,
including
anti-inflammatory,
antioxidant,
anti-cholesterolemic,
protective
activity
for
immune
system,
heart
failure,
coronary
industrial
processing
formation
juice
oil.
solid
residues,
referred
"pastazzo",
normally
used
feed
livestock
pectin
production.
fiber
(BF)
be
obtained
pastazzo
could
exert
interesting
effect
thanks
its
content
polyphenols.
aims
this
work
were
twofold:
(a)
have
more
information
(composition,
polyphenol
flavonoid
content,
antioxidant
activity,
etc.)
on
BF
powder
(b)
verify
effects
vitro
model
neurotoxicity
induced
by
treatment
with
amyloid
beta
protein
(Aβ).
In
particular,
study
cell
lines
was
carried
out
both
neurons
oligodendrocytes,
measure
involvement
glia
compare
that
neurons.
results
showed
contains
polyphenols
flavonoids
able
exercise
property.
Moreover,
exerts
action
damage
Aβ,
defense
found
experiments
viability,
accumulation
reactive
oxygen
species,
expression
caspase-3,
necrotic
apoptotic
death.
all
these
results,
oligodendrocytes
always
sensitive
fragile
than
Further
needed,
if
trend
confirmed,
AD;
at
same
time,
help
avoid
products.
Journal of Functional Foods,
Год журнала:
2022,
Номер
96, С. 105192 - 105192
Опубликована: Июль 28, 2022
•
Solid
tumors
rely
on
pathological
angiogenesis
to
meet
their
metabolic
needs
and
facilitate
spread.
Glioblastoma
multiforme
(GBM),
an
aggressive
deadliest
brain
malignancy,
is
represented
by
multi-mechanistic
exuberant
angiogenic
properties.
The
current
study
summarized
advances
in
the
preclinical
clinical
investigations
concerning
impact
of
phytochemicals
GBM
tumor
focusing
mechanism
action.
Current
treatment
efforts
inhibit
neovascularization
using
monoclonal
antibodies
(e.g.,
bevacizumab)
generally
fail
enhance
patients’
lifespan
due
inadequate
medication
transport
lack
a
multimodal
action
accentuating
necessity
developing
novel
medicines.
Phytochemicals
such
as
curcumin,
ellagic
acid,
quercetin,
resveratrol
are
secondary
metabolites
plants
that
have
frequently
been
demonstrated
enclose
potential
suppressing
growth
through
inhibiting
various
mechanisms
involved
neovessel
creation.
Furthermore,
we
sought
identify
overlooked
factors
for
future
research.
Frontiers in Cell and Developmental Biology,
Год журнала:
2022,
Номер
10
Опубликована: Окт. 4, 2022
Glioblastoma
(GBM)
is
the
most
common
and
aggressive
tumor
of
central
nervous
system,
which
has
a
highly
invasive
growth
pattern,
creates
poor
prospects
for
patient
survival.
Chemotherapy
surgery
are
limited
by
anticancer
drug
resistance
invasion.
Evidence
suggests
that
combinations
treatments
may
be
more
effective
than
single
drugs
alone.
Natural
polyphenolic
compounds
have
potential
as
treatment
glioblastoma
considered
drugs.
Although
these
beneficial
effects
promising,
efficacy
natural
in
GBM
their
bioavailability
blood-brain
barrier
permeability.
Many
them
significant
effect
on
reducing
progression
through
mechanisms
such
reduced
migration
cell
invasion
or
chemosensitization.
Various
chemical
formulations
been
proposed
to
improve
pharmacological
properties.
This
review
summarizes
physiological
models
modulating
signaling
pathways
involved
angiogenesis,
apoptosis,
chemoresistance,
Polyphenolic
emerging
promising
agents
combating
glioblastoma.
However,
clinical
trials
still
needed
confirm
properties
vitro
vivo
.
Molecules,
Год журнала:
2024,
Номер
29(8), С. 1708 - 1708
Опубликована: Апрель 10, 2024
Glioblastoma
(GBM),
the
most
frequent
and
lethal
brain
cancer
in
adults,
is
characterized
by
short
survival
times
high
mortality
rates.
Due
to
resistance
of
GBM
cells
conventional
therapeutic
treatments,
scientific
interest
focusing
on
search
for
alternative
efficient
adjuvant
treatments.
This
study
explores
the
anticancer
potential
of
Thioflavin-derived
zinc
nanoparticles
(Th-ZnNPs)
using
both
in
vitro
and
silico
methods.
Thioflavin,
known
for
its
specific
binding
properties,
faces
challenges
such
as
bioavailability,
rapid
metabolism,
solubility.
To
overcome
these
limitations
enhance
therapeutic
efficacy,
nanotechnology
was
utilized
to
synthesize
Th-ZnNPs.
These
(NPs)
are
designed
improve
drug
delivery
effectiveness.
The
Beclin
protein,
which
plays
a
critical
role
regulating
autophagy
cancer
cells,
identified
target
NPs.
aims
evaluate
interaction
between
Th-ZnNPs
protein
glioblastoma
cell
lines
assess
NPs
novel
agents.
