Опубликована: Янв. 1, 2024
8-oxo-2-deoxiguanosina 8-oxo-dG: 8-oxo-2'-deoxiguanosina ADH: álcool desidrogenase AKT:
Molecular Medicine Reports, Год журнала: 2022, Номер 26(4)
Опубликована: Авг. 9, 2022
Melanoma is the most aggressive form of skin cancer with poorest prognosis and its pathogenesis has yet to be fully elucidated. As key factors that regulate cellular homeostasis, both reactive oxygen species (ROS) autophagy are involved in development melanoma, from melanomagenesis progression drug resistance. However, interaction between ROS etiology treatment melanoma not well characterized. The present review examined production role oxidative stress summarized ROS‑mediated cell fate decision following various anticancer drugs. findings may lead a better understanding suggest promising options for this disease.
Язык: Английский
Процитировано
12
Cell Death Discovery, Год журнала: 2023, Номер 9(1)
Опубликована: Окт. 25, 2023
Abstract Metastasis is a formidable challenge in the prognosis of melanoma. Accurately predicting metastatic potential non-metastatic melanoma (NMM) and determining effective postoperative adjuvant treatments for inhibiting metastasis remain uncertain. In this study, we conducted comprehensive analyses metastases using bulk single-cell RNA sequencing data, enabling construction score (MET score) through diverse machine-learning algorithms. The reliability robustness MET were validated various vitro assays vivo models. Our findings revealed distinct molecular landscape characterized by enrichment metastasis-related pathways, intricate cell–cell communication, heightened infiltration pro-angiogenic tumor-associated macrophages compared to NMM. Importantly, patients high group exhibited poorer prognoses an immunosuppressive microenvironment, featuring increased regulatory T cells decreased CD8 + cells, low patient group. Expression PD-1 was markedly higher with scores. Anti-PD-1 (aPD-1) therapy profoundly affected antitumor immunity activation inhibition these patients. summary, our study demonstrates effectiveness potential. For scores, aPD-1 may be treatment strategy inhibit metastasis. Patients scores benefit from combination therapies.
Язык: Английский
Процитировано
5
Cells, Год журнала: 2022, Номер 11(9), С. 1492 - 1492
Опубликована: Апрель 29, 2022
Lysosomes are membrane-bound vesicles that play roles in the degradation and recycling of cellular waste homeostasis maintenance within cells. False alterations lysosomal functions can lead to broad detrimental effects cause various diseases, including cancers. Cancer cells rapidly proliferative invasive highly dependent on effective function. Malignant melanoma is most lethal form skin cancer, with high metastasis characteristics, drug resistance, aggressiveness. It critical understand role lysosomes pathogenesis order improve outcomes patients. In this mini-review, we compile our current knowledge lysosomes’ tumorigenesis, progression, therapy treatment strategies related melanoma.
Язык: Английский
Процитировано
8
International Journal of Genomics, Год журнала: 2022, Номер 2022, С. 1 - 13
Опубликована: Окт. 20, 2022
The aim of this study is to demonstrate the expression and clinicopathological significance complement C1q B chain (C1QB) in cervical cancer.In total, 120 cancer tissues, as well 20 samples each high-grade squamous intraepithelial lesions (HSILs), low-grade (LSILs), benign tissue, were collected evaluate C1QB protein via immunohistochemical staining. We conducted an integrated analysis mRNA using public microarrays RNA-seq data sets by calculating standard mean differences (SMDs). Simultaneously, we explored relations with parameters P16, Ki-67, P53.The was higher than that LSIL, HSIL (p < 0.05). A combined SMD 0.65 (95% CI: [0.52, 0.79], p 0.001) revealed upregulation cancer. may also be related depth infiltration, lymphovascular invasion, perineural invasion found positively correlated P16 Ki-67 gene set enrichment showed participate apoptosis autophagy. relationship predicted between drug sensitivity cisplatin, paclitaxel, docetaxel.We confirmed overexpression at both levels for first time. serve oncogene tumorigenesis cancer, but possibility requires further study.
Язык: Английский
Процитировано
3
Bulletin of Experimental Biology and Medicine, Год журнала: 2024, Номер 176(3), С. 376 - 381
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0
Free Radical Research, Год журнала: 2024, Номер unknown, С. 1 - 12
Опубликована: Дек. 3, 2024
Plasma-activated Ringer's lactate (PAL) solution prepared by irradiating an intravenous with a non-equilibrium atmospheric pressure plasma is potential new cancer therapy having no side effects. However, the induction of autophagy to avoid cell death has been confirmed occur following exposure PAL solution. It thought that antitumor effect could be weakened this process, which meant maintain homeostasis in cells and assists tumorigenesis. Thus, it would helpful devise PAL-based therapies inhibit autophagy. Unfortunately, not yet clear substances promote The present work examined mechanism induces when treating MCF-7 human breast cells. Autophagy was found temporarily induced upon solution, suggesting contributes proliferation. Although associated reactive oxygen nitrogen species and/or acidic environments, study, significant observed using diluted 1/256x without these stressors. Acetate, glyoxylate 2,3-dimethyltartrate were determined Interestingly, either induce or depending on concentration.
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2024
8-oxo-2-deoxiguanosina 8-oxo-dG: 8-oxo-2'-deoxiguanosina ADH: álcool desidrogenase AKT:
Процитировано
0
Опубликована: Янв. 1, 2024
8-oxo-2-deoxiguanosina 8-oxo-dG: 8-oxo-2'-deoxiguanosina ADH: álcool desidrogenase AKT:
Процитировано
0
Опубликована: Янв. 1, 2024
8-oxo-2-deoxiguanosina 8-oxo-dG: 8-oxo-2'-deoxiguanosina ADH: álcool desidrogenase AKT:
Процитировано
0
Опубликована: Янв. 1, 2024
8-oxo-2-deoxiguanosina 8-oxo-dG: 8-oxo-2'-deoxiguanosina ADH: álcool desidrogenase AKT:
Процитировано
0