Seminars in Immunopathology,
Год журнала:
2023,
Номер
unknown
Опубликована: Янв. 12, 2023
Abstract
High-grade
serous
ovarian
cancer
(HGSOC)
is
the
most
lethal
gynecological
malignancy.
Its
diagnosis
at
advanced
stage
compounded
with
its
excessive
genomic
and
cellular
heterogeneity
make
curative
treatment
challenging.
Two
critical
therapeutic
challenges
to
overcome
are
carboplatin
resistance
lack
of
response
immunotherapy.
Carboplatin
results
from
diverse
cell
autonomous
mechanisms
which
operate
in
different
combinations
within
across
tumors.
The
immunotherapy
highly
likely
be
related
an
immunosuppressive
HGSOC
tumor
microenvironment
overrides
any
clinical
benefit.
Results
a
number
studies,
mainly
using
transcriptomics,
indicate
that
immune
(iTME)
plays
role
response.
However,
patients
receiving
treatment,
exact
mechanistic
details
unclear.
During
past
decade,
multiplex
single-cell
proteomic
technologies
have
come
forefront
biomedical
research.
Mass
cytometry
or
by
time-of-flight,
measures
up
60
parameters
single
cells
suspension.
Multiplex
imaging
allow
simultaneous
measurement
proteins
spatial
resolution
interrogation
cell–cell
interactions.
This
review
suggests
functional
interplay
between
responses
could
clarified
through
application
technologies.
We
conclude
for
better
care,
integral
component
multimodal
biomarker
development
also
includes
genomics
radiomics.
Collection
matched
samples
before
on
will
success
these
efforts.
Cancers,
Год журнала:
2022,
Номер
15(1), С. 286 - 286
Опубликована: Дек. 31, 2022
Exosomes
are
nanovesicles
secreted
into
biofluids
by
various
cell
types
and
have
been
implicated
in
different
physiological
pathological
processes.
Interestingly,
a
plethora
of
studies
emphasized
the
mediating
role
exosomes
bidirectional
communication
between
donor
recipient
cells.
Among
cargoes
exosomes,
long
non-coding
RNAs
(lncRNAs)
identified
as
crucial
regulators
cancer
cells
immune
tumor
microenvironment
(TME)
that
can
interfere
with
innate
adaptive
responses
to
affect
therapeutic
efficiency.
Recently,
few
major
focused
on
exosomal
lncRNA-mediated
interaction
infiltrated
TME.
Nevertheless,
dearth
pertains
regulating
lncRNAs
is
still
early
stages.
Comprehensive
mechanisms
immunity
not
well
understood.
Herein,
we
provide
an
overview
immunomodulatory
function
treatment
resistance.
In
addition,
also
summarize
potential
strategies
toward
Journal of Translational Medicine,
Год журнала:
2023,
Номер
21(1)
Опубликована: Ноя. 15, 2023
Abstract
The
pivotal
role
of
the
tumor
microenvironment
(TME)
in
initiation
and
advancement
hepatocellular
carcinoma
(HCC)
is
widely
acknowledged,
as
it
fosters
proliferation
metastasis
HCC
cells.
Within
intricate
TME
HCC,
tumor-associated
macrophages
(TAMs)
represent
a
significant
constituent
non-malignant
TAMs
engage
direct
communication
with
cancer
cells
while
also
exerting
influence
on
other
immune
to
adopt
tumor-supportive
phenotype
that
facilitates
progression.
Among
multifaceted
mechanisms
at
play,
metabolic
reprogramming
both
leads
phenotypic
alterations
functional
modifications
macrophages.
This
comprehensive
review
elucidates
interplay
between
cellular
metabolism
macrophage
phenotype/polarization,
providing
an
overview
associated
signaling
molecules
potential
therapeutic
strategies
for
HCC.
Immunology,
Год журнала:
2024,
Номер
173(1), С. 14 - 32
Опубликована: Апрель 15, 2024
Despite
progress
in
cancer
immunotherapy,
ovarian
(OC)
prognosis
continues
to
be
disappointing.
Recent
studies
have
shed
light
on
how
not
just
tumour
cells,
but
also
the
complex
microenvironment,
contribute
this
unfavourable
outcome
of
OC
immunotherapy.
The
complexities
immune
microenvironment
categorize
as
a
'cold
tumour'.
Nonetheless,
understanding
precise
mechanisms
through
which
influences
effectiveness
immunotherapy
remains
an
ongoing
scientific
endeavour.
This
review
primarily
aims
dissect
inherent
characteristics
and
behaviours
diverse
cells
within
along
with
exploration
into
its
reprogramming
metabolic
changes.
It
is
expected
that
these
insights
will
elucidate
operational
dynamics
lay
theoretical
groundwork
for
improving
efficacy
management.
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 22, 2025
Ovarian
cancer
(OC)
remains
the
most
lethal
gynecological
malignancy,
primarily
due
to
its
late-stage
diagnosis,
frequent
recurrence,
and
resistance
conventional
chemotherapy.
A
critical
factor
contributing
OC's
aggressiveness
is
tumor
microenvironment
(TME),
particularly
presence
polarization
of
tumor-associated
macrophages
(TAMs).
TAMs,
often
skewed
toward
an
immunosuppressive
M2-like
phenotype,
facilitate
growth,
angiogenesis,
metastasis,
therapy.
This
comprehensive
review
delves
into
multifaceted
regulation
macrophage
in
OC,
highlighting
key
molecular
pathways
such
as
PTEN
loss,
Wnt/β-catenin
signaling,
NF-κB,
Myc,
STAT3,
JNK,
among
others.
Additionally,
it
explores
role
chemokines,
non-coding
RNAs,
various
proteins
modulating
TAM
phenotypes.
Emerging
evidence
underscores
significance
extracellular
vesicles
(EVs)
ovarian
stem
cells
(CSCs)
promoting
M2
polarization,
thereby
enhancing
progression
therapy
resistance.
The
also
identifies
biomarkers
associated
with
including
CD163,
LILRB1,
MUC2,
others,
which
hold
prognostic
therapeutic
potential.
Therapeutic
strategies
targeting
TAMs
are
extensively
discussed,
encompassing
oncolytic
viruses,
engineered
EVs,
immunotherapies,
nanoparticles,
targeted
therapies,
natural
products.
These
approaches
aim
reprogram
from
a
pro-tumorigenic
state
anti-tumorigenic
M1
immune
responses
overcoming
treatments
chemotherapy
checkpoint
inhibitors.
Furthermore,
addresses
interplay
between
resistance,
emphasizing
need
for
novel
interventions
modulate
TME
effectively.
By
synthesizing
current
knowledge
on
cancer,
this
study
potential
improve
clinical
outcomes
personalize
treatment
OC
patients.
Continued
research
domain
essential
develop
robust
frameworks
that
can
mitigate
enhance
efficacy
existing
therapies.
Clinical and Experimental Medicine,
Год журнала:
2024,
Номер
24(1)
Опубликована: Июль 13, 2024
Tumor-associated
macrophages
(TAMs)
represent
one
of
the
most
abundant
tumor-infiltrating
stromal
cells,
and
their
normal
function
in
tumor
microenvironment
(TME)
is
to
suppress
cells
by
producing
cytokines
which
trigger
both
direct
cell
cytotoxicity
antibody-mediated
immune
response.
However,
upon
prolonged
exposure
TME,
classical
these
so-called
M1-type
TAMs
can
be
converted
another
type,
"M2-type,"
are
recruited
so
that
they
promote
growth
metastasis.
This
reason
why
accumulation
TME
correlated
with
poor
prognosis
cancer
patients.
Both
M1-
M2-types
have
high
degree
plasticity,
M2-type
reprogrammed
for
therapeutic
purposes.
characteristic
introduces
as
promising
target
developing
novel
treatments.
In
addition,
inhibition
blocking
recruitment
well
depletion
inducing
apoptosis,
other
approaches
effective
immunotherapy
cancer.
this
review,
we
summarize
potential
targeted
provide
an
up-to-date
about
strategies
targeting
TAMs.
Journal of Experimental & Clinical Cancer Research,
Год журнала:
2024,
Номер
43(1)
Опубликована: Авг. 22, 2024
Abstract
Renal
cell
carcinoma
(RCC)
is
one
of
the
most
common
tumors
that
afflicts
urinary
system,
accounting
for
90–95%
kidney
cancer
cases.
Although
its
incidence
has
increased
over
past
decades,
pathogenesis
still
unclear.
Tumor-associated
macrophages
(TAMs)
are
prominent
immune
cells
in
tumor
microenvironment
(TME),
comprising
more
than
50%
volume.
By
interacting
with
cells,
TAMs
can
be
polarized
into
two
distinct
phenotypes,
M1-type
and
M2-type
TAMs.
In
TME,
TAMs,
which
known
to
promote
tumorigenesis,
abundant
suppress
growth.
This
ratio
M1
M2
create
an
immunosuppressive
environment
contributes
progression
survival.
review
focused
on
role
RCC,
including
their
polarization,
impacts
proliferation,
angiogenesis,
invasion,
migration,
drug
resistance,
immunosuppression.
addition,
we
discussed
potential
targeting
clinical
therapy
RCC.
A
deeper
understanding
molecular
biology
essential
exploring
innovative
therapeutic
strategies
treatment
Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Ноя. 10, 2022
Cancer
is
a
disease
that
induces
many
local
and
systemic
changes
in
immunity.
The
difficult
nature
of
ovarian
cancer
stems
from
the
lack
characteristic
symptoms
contributes
to
delayed
diagnosis
treatment.
Despite
enormous
progress
immunotherapy,
its
efficacy
remains
limited.
heterogeneity
tumors,
diagnostic
biomarkers,
complex
immune
landscape
are
main
challenges
treatment
cancer.
Integrative
approaches
combine
tumor
microenvironment
–
immunity
together
with
periphery
urgently
needed
improve
understanding
In
fact,
multiparametric
analyses
poised
our
immunology.
We
outline
an
integrative
approach
including
Understanding
both
localized
responses
will
be
crucial
boosting
immunotherapies
patients.
Cancers,
Год журнала:
2022,
Номер
14(21), С. 5224 - 5224
Опубликована: Окт. 25, 2022
The
interaction
between
tumor
cells
and
macrophages
in
the
microenvironment
plays
an
essential
role
metabolic
changes
reprograms
them
towards
a
pro-tumorigenic
phenotype.
Increasing
evidence
indicates
that
macrophage
metabolism
is
highly
complex
process
may
not
be
as
simple
previously
thought.
Pro-inflammatory
stimuli
switch
M1-like
phenotype
rely
mainly
on
aerobic
glycolysis
fatty
acid
synthesis,
whereas
anti-inflammatory
M2-like
depend
more
oxidative
phosphorylation
(OXPHOS)
oxidation.
However,
this
metabolically
reprogrammed
phenotypic
remained
mystery
for
while.
Therefore,
through
review,
we
tend
to
describe
how
immunometabolism
determines
phenotypes
functions
microenvironments
(TMEs).
Furthermore,
have
discussed
reprogramming
TAM
can
used
therapeutic
intervention
drug
resistance
ovarian
cancer.
