Exosomes: from basic research to clinical diagnostic and therapeutic applications in cancer
Cellular Oncology,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 19, 2024
Язык: Английский
Macrophage-derived lncRNAs in cancer: regulators of tumor progression and therapeutic targets
Medical Oncology,
Год журнала:
2025,
Номер
42(4)
Опубликована: Март 6, 2025
Язык: Английский
The mechanism of action and therapeutic potential of tumor-associated macrophages in tumor immune evasion
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 22, 2025
Tumor-associated
macrophages
(TAMs)
play
a
multifaceted
role
in
tumor
progression.
As
specialized
immune
cells,
are
capable
of
phagocytosis
and
digesting
foreign
substances,
as
well
removing
harmful
substances
including
cellular
debris
cells.
Under
specific
pathological
conditions,
circulating
monocytes
can
be
recruited
into
the
microenvironment
differentiate
TAMs.
Macrophages
generally
polarized
two
distinct
subpopulations:
classically
activated
(M1)
alternatively
(M2).
TAMs
constitute
significant
proportion
mononuclear
leukocyte
population
solid
tumors,
exhibiting
complex
dualistic
relationship
with
Substantial
evidence
indicates
that
interact
facilitating
their
evasion
while
promoting
invasion
metastasis.
This
review
focuses
on
mechanism
regulation
response
to
various
macrophage-based
tumor-targeted
therapeutic
strategies.
It
will
provide
reference
for
research
macrophage-centered
therapy
strategies
application
clinical
practice.
Язык: Английский
Diagnostic, prognostic, and immunological roles of FUT8 in lung adenocarcinoma and lung squamous cell carcinoma
PLoS ONE,
Год журнала:
2025,
Номер
20(5), С. e0321756 - e0321756
Опубликована: Май 15, 2025
Lung
cancer
remains
the
leading
cause
of
malignant
tumors
worldwide
in
terms
incidence
and
mortality,
posing
a
significant
threat
to
human
health.
Given
that
distant
metastases
typically
occur
at
time
initial
diagnosis,
poor
5-year
survival
rate
among
patients,
it
is
crucial
identify
markers
for
prognosis,
therapeutic
efficacy
monitoring.
Abnormal
glycosylation
hallmark
cells,
characterized
by
disruption
core
fucosylation,
which
predominantly
driven
enzyme
fucosyltransferase
8
(FUT8).
Evidence
indicates
FUT8
pivotal
onset
progression,
influencing
cellular
pathways.
Utilizing
bioinformatics
approaches,
we
have
investigated
lung
cancer,
resulting
more
systematic
comprehensive
understanding
its
role
disease’s
pathogenesis.
In
this
study,
employed
analyze
differential
expression
between
LUAD
LUSC.
We
observed
upregulation
both
LUSC,
associated
with
unfavorable
higher
diagnostic
utility
LUAD.
GO/KEGG
analysis
revealed
primary
association
spliceosome.
Immunologically,
was
significantly
immune
cell
infiltration
checkpoint
activity,
notable
positive
correlation
M2
macrophage
infiltration.
Our
may
serve
as
potential
biomarker
diagnosis
could
represent
target
LUSC
immunotherapy.
Язык: Английский
Tumor-Associated Macrophages: Polarization, Immunoregulation, and Immunotherapy
Cells,
Год журнала:
2025,
Номер
14(10), С. 741 - 741
Опубликована: Май 19, 2025
Tumor-associated
macrophages’
(TAMs)
origin,
polarization,
and
dynamic
interaction
in
the
tumor
microenvironment
(TME)
influence
cancer
development.
They
are
essential
for
homeostasis,
monitoring,
immune
protection.
Cells
from
bone
marrow
or
embryonic
progenitors
dynamically
polarize
into
pro-
anti-tumor
M2
M1
phenotypes
based
on
cytokines
metabolic
signals.
Recent
advances
TAM
heterogeneity,
characterization,
immunological
responses,
therapy
described
here.
The
manuscript
details
functions
their
role
resistance
to
PD-1/PD-L1
blockade.
Similarly,
TAM-targeted
approaches,
such
as
CSF-1R
inhibition
PI3Kγ-driven
reprogramming,
discussed
address
immunity
suppression.
Furthermore,
innovative
biomarkers
combination
may
enhance
TAM-centric
therapies.
It
also
stresses
relevance
of
this
distinct
cell
human
health
disease,
which
could
impact
future
research
Язык: Английский
Spatial transcriptomics: a new frontier in accurate localization of breast cancer diagnosis and treatment
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 8, 2024
Breast
cancer
is
one
of
the
most
prevalent
cancers
in
women
globally.
Its
treatment
and
prognosis
are
significantly
influenced
by
tumor
microenvironment
heterogeneity.
Precision
therapy
enhances
efficacy,
reduces
unwanted
side
effects,
maximizes
patients’
survival
duration
while
improving
their
quality
life.
Spatial
transcriptomics
significant
importance
for
precise
breast
cancer,
playing
a
critical
role
revealing
internal
structural
differences
tumors
composition
microenvironment.
It
offers
novel
perspective
studying
spatial
structure
cell
interactions
within
tumors,
facilitating
more
effective
personalized
treatments
cancer.
This
article
will
summarize
latest
findings
diagnosis
from
transcriptomics,
focusing
on
revelation
microenvironment,
identification
new
therapeutic
targets,
enhancement
disease
diagnostic
accuracy,
comprehension
progression
metastasis,
assessment
drug
responses,
creation
high-resolution
maps
cells,
representation
heterogeneity,
support
clinical
decision-making,
particularly
elucidating
immunotherapy
correlation
with
outcomes.
Язык: Английский