IntechOpen eBooks,
Год журнала:
2023,
Номер
unknown
Опубликована: Авг. 21, 2023
New
ways
of
looking
at
tumor
genetics
and
dynamics
have
been
developed:
the
Liquid
Biopsy
(LB),
which
has
incorporated
into
clinical
practice
as
a
noninvasive
analysis
circulating
material
derived
from
tumors,
represents
an
innovative
tool
in
precision
oncology
overcomes
current
limitations
associated
with
tissue
biopsies.
An
LB
is
new
great
value,
constituting
diagnostic,
prognostic,
predictive
marker.
The
elements
that
makeup
are
cells
(CTCs)
nucleic
acids
(ctNA:
DNA
or
RNA)
free
contained
exosomes,
microvesicles,
platelets.
ctDNA
CTCs
only
one’s
components
application
approved
by
US
Food
Drug
Administration
(FDA).
Sensors and Actuators A Physical,
Год журнала:
2024,
Номер
376, С. 115625 - 115625
Опубликована: Июнь 24, 2024
The
integration
of
CRISPR
technology
with
microfluidic-based
biosensors
has
greatly
expanded
its
applications
in
medicine
and
molecular
biology.
This
combination
offers
enhanced
sensitivity
selectivity
medical
diagnostics.
CRISPR-powered
microfluidics
enables
the
accurate
quantification
DNA
RNA
associated
diseases
such
as
cancer,
viral
infections,
bacterial
diseases.
precise
targeting
capabilities
allow
for
detection
specific
genetic
sequences,
aiding
early
diagnosis,
disease
monitoring,
treatment
assessment.
improves
specificity
by
leveraging
programmable
nature
coupling
it
signal
readouts.
However,
challenges
assay
optimization,
standardization,
device
fabrication
need
to
be
addressed.
Additionally,
complexity
presents
potential
limitations
terms
off-target
effects
unintended
modifications.
Overall,
holds
tremendous
diagnostics,
but
further
research
development
are
required
fully
exploit
benefits
clinical
settings.
Stem Cell Research & Therapy,
Год журнала:
2023,
Номер
14(1)
Опубликована: Ноя. 28, 2023
Abstract
Epithelial–mesenchymal
transition
(EMT)
is
a
cell
remodeling
process
in
which
epithelial
cells
undergo
reversible
phenotype
switch
via
the
loss
of
adhesion
capacity
and
acquisition
mesenchymal
characteristics.
In
other
words,
EMT
activation
can
increase
invasiveness
metastatic
properties,
prevent
sensitivity
tumor
to
chemotherapeutics,
as
have
higher
resistance
chemotherapy
immunotherapy.
orchestrated
by
complex
multifactorial
network,
often
linked
episodic,
transient,
or
partial
events.
A
variety
factors
been
implicated
development.
Based
on
this
concept,
multiple
metabolic
pathways
master
transcription
factors,
such
Snail,
Twist,
ZEB,
drive
EMT.
Emerging
evidence
suggests
that
oxidative
stress
plays
significant
role
induction.
One
emerging
theory
reducing
mitochondrial-derived
reactive
oxygen
species
production
may
contribute
This
review
describes
how
are
induction
addresses
involvement
signaling
pathways.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(17), С. 9463 - 9463
Опубликована: Авг. 30, 2024
Colorectal
cancer
(CRC)
represents
a
significant
global
health
burden,
with
high
incidence
and
mortality
rates
worldwide.
Recent
progress
in
research
highlights
the
distinct
clinical
molecular
characteristics
of
colon
versus
rectal
cancers,
underscoring
tumor
location's
importance
treatment
approaches.
This
article
provides
comprehensive
review
our
current
understanding
CRC
epidemiology,
risk
factors,
pathogenesis,
management
strategies.
We
also
present
intricate
cellular
architecture
colonic
crypts
their
roles
intestinal
homeostasis.
carcinogenesis
multistep
processes
are
described,
covering
conventional
adenoma-carcinoma
sequence,
alternative
serrated
pathways,
influential
Vogelstein
model,
which
proposes
sequential
Cancer Biology and Medicine,
Год журнала:
2024,
Номер
20(12), С. 985 - 1020
Опубликована: Янв. 2, 2024
Cancer
stem
cells
(CSCs)
are
a
small
subset
of
in
cancers
that
thought
to
initiate
tumorous
transformation
and
promote
metastasis,
recurrence,
resistance
treatment.
Growing
evidence
has
revealed
the
existence
CSCs
various
types
suggested
differentiate
into
diverse
lineage
contribute
tumor
progression.
We
may
be
able
overcome
limitations
cancer
treatment
with
comprehensive
understanding
biological
features
mechanisms
underlying
therapeutic
CSCs.
This
review
provides
an
overview
properties,
biomarkers,
shown
by
Recent
findings
on
metabolic
features,
especially
fatty
acid
metabolism
ferroptosis
CSCs,
highlighted,
along
promising
targeting
strategies.
Targeting
is
potential
plan
conquer
prevent
relapse
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(21), С. 13582 - 13582
Опубликована: Ноя. 5, 2022
Colorectal
cancer
(CRC)
is
the
third
most
common
worldwide.
The
high
mortality
from
CRC
mainly
related
to
metastasis
affecting
distant
organs
and
their
function.
Dissemination
of
tumor
cells
primary
hematogeneous
spread
are
considered
crucial
in
formation
metastases.
analysis
circulating
(CTCs)
CTC
clusters
blood
can
be
used
for
early
detection
invasive
cancer.
Moreover,
CTCs
have
a
prognostic
significance
monitoring
malignant
disease
or
response
chemotherapy.
This
work
presents
an
overview
research
conducted
on
with
aim
finding
suitable
systems
assessing
possibility
clinical
applications
patients
CRC.
IntechOpen eBooks,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 19, 2025
Cancer
stem
cells
(CSCs)
are
a
crucial
subpopulation
in
gynecological
tumors,
defined
by
their
self-renewal,
differentiation
potential,
and
resistance
to
conventional
therapies.
These
central
tumor
initiation,
progression,
metastasis,
recurrence,
making
them
key
targets
for
innovative
therapeutic
strategies.
This
chapter
will
explore
the
molecular
mechanisms
that
regulate
CSCs,
focusing
on
signaling
pathways
such
as
Wnt,
Notch,
Hedgehog,
which
critical
CSC
maintenance
survival.
It
also
examine
emerging
approaches
aimed
at
eradicating
including
pathway
inhibitors,
immune-based
strategies,
combinatorial
treatments.
By
targeting
these
hold
promise
of
overcoming
achieving
more
reliable
clinical
responses
cancers.
Further,
this
delves
into
challenges
future
directions
translating
CSC-targeted
therapies
practice.
