Effects of Functional and Nutraceutical Foods in the Context of the Mediterranean Diet in Patients Diagnosed with Breast Cancer DOI Creative Commons
Giovanna Flore, Andrea Deledda, Mauro Lombardo

и другие.

Antioxidants, Год журнала: 2023, Номер 12(10), С. 1845 - 1845

Опубликована: Окт. 11, 2023

Several studies report that breast cancer survivors (BCS) tend to have a poor diet, as fruit, vegetable, and legume consumption is often reduced, resulting in decreased intake of nutraceuticals. Moreover, weight gain has been commonly described among BCS during treatment, increasing recurrence rate mortality. Improving lifestyle nutrition after the diagnosis BC may important benefits on patients’ general health specific clinical outcomes. The Mediterranean diet (MD), known for its multiple beneficial effects health, can be considered nutritional pool comprising several nutraceuticals: bioactive compounds foods with anti-inflammatory antioxidant effects. Recent scientific advances led identification nutraceuticals could amplify MD favorably influence gene expression these patients. Nutraceuticals postdiagnostic phase BC, including helping mitigate adverse chemotherapy radiotherapy. valid easy-to-follow option managing excess weight. aim this narrative review evaluate recent literature possible consuming functional nutraceutical framework BCS.

Язык: Английский

Vaginal and rectal microbiome contribute to genital inflammation in chronic pelvic pain DOI Creative Commons
Nicole R. Jimenez,

Taylor Norton,

Gurbeen Diadala

и другие.

BMC Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Июль 8, 2024

Abstract Background Chronic pelvic pain (CPP) is a multifactorial syndrome that can substantially affect patient’s quality of life. Endometriosis one cause CPP, and alterations the immune microbiome profiles have been observed in patients with endometriosis. The objective this pilot study was to investigate differences vaginal gastrointestinal microbiomes cervicovaginal microenvironment CPP endometriosis diagnosis compared those without no CPP. Methods Vaginal swabs, rectal lavages (CVL) were collected among individuals undergoing gynecologic laparoscopy. Participants grouped based on seeking care for chronic and/or pathology results: (CPP-Endo) ( n = 35), 23), or (controls) 15). Sensitivity analyses performed location, stage, co-occurring conditions (abnormal uterine bleeding, fibroids). 16S rRNA sequencing profile microbiome, panel soluble mediators quantified using multiplex assay. Statistical analysis conducted SAS, R, MicrobiomeAnalyst, MetaboAnalyst, QIIME 2. Results Significant between participants alone, CPP-Endo, surgical controls body mass index, ethnicity, ovarian cysts, fibroids. In analysis, both alone CPP-Endo exhibited lower alpha diversity than controls, groups revealed enrichment irritable bowel syndrome-associated bacteria. an increased abundance Streptococcus anginosus Ruminococcus . Patients endometrioma (s) demonstrated , Lactobacillus, Prevotella other sites. Further, abnormal bleeding associated bacterial vaginosis-associated Immunoproteomic distinctly clustered by controls. enriched TNF⍺, MDC, IL-1⍺. Conclusions differ endometriosis, which may be useful personalized treatment from causes Further investigation warranted additional conditions, such as AUB/fibroids, add complexity these reveal distinct pathogenic bacteria mucosal This provides foundational microbiome-immunoproteomic knowledge related pain, help improve pain.

Язык: Английский

Процитировано

4
Nutrition Intervention and Microbiome Modulation in the Management of Breast Cancer DOI Open Access

Yue Jiang,

Yuanyuan Li

Nutrients, Год журнала: 2024, Номер 16(16), С. 2644 - 2644

Опубликована: Авг. 10, 2024

Breast cancer (BC) is one of the most common cancers worldwide and a leading cause cancer-related deaths among women. The escalating incidence BC underscores necessity multi-level treatment. complex heterogeneous disease involving many genetic, lifestyle, environmental factors. Growing evidence suggests that nutrition intervention an evolving effective prevention treatment strategy for BC. In addition, human microbiota, particularly gut now widely recognized as significant player contributing to health or status. It also associated with risk development This review will focus on in BC, including dietary patterns, bioactive compounds, nutrients affect therapeutic responses both animal studies. Additionally, this paper examines impacts these interventions modulating composition functionality microbiome, highlighting microbiome-mediated mechanisms combination factors microbes discussed. Insights from emphasize comprehensive management focuses nutrition–microbiome axis.

Язык: Английский

Процитировано

4
Cancer and the Microbiome of the Human Body DOI Open Access
Lourdes Herrera‐Quintana, Héctor Vázquez‐Lorente, María López-Garzón

и другие.

Nutrients, Год журнала: 2024, Номер 16(16), С. 2790 - 2790

Опубликована: Авг. 21, 2024

Cancer remains a public health concern worldwide, with its incidence increasing worldwide and expected to continue growing during the next decades. The microbiome has emerged as central factor in human disease, demonstrating an intricate relationship between cancer. Although some microbiomes present within local tissues have been shown restrict cancer development, mainly by interacting cells or host immune system, microorganisms are harmful risk factors for development. This review summarizes recent evidence concerning of most common types (i.e., lung, head neck, breast, gastric, colorectal, prostate, cervix cancers), providing general overview future clinical approaches perspectives.

Язык: Английский

Процитировано

4
Obesity, dysbiosis and inflammation: interactions that modulate the efficacy of immunotherapy DOI Creative Commons
Ashutosh S. Yende, Dipali Sharma

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Авг. 26, 2024

Recent years have seen an outstanding growth in the understanding of connections between diet-induced obesity, dysbiosis and alterations tumor microenvironment. Now we appreciate that gut can exert important effects distant target tissues via specific microbes metabolites. Multiple studies examined how obese state is associated with direct various physiological processes help maintain a bidirectional crosstalk. Another tightly linked factor sustained low grade inflammation microenvironment modulated by both dysbiosis, influences as well response to immunotherapy. Our review brings together these aspects explores their connections. In this review, discuss modulates components breast microbiota achieve low-grade inflammation. We explore crosstalk different microbes, they might modulate Discussing from multiple types, delve find common microbial characteristics may positively or negatively influence immunotherapy efficacy cancer guide future studies.

Язык: Английский

Процитировано

4
Effects of Fecal Sewage and Antibiotic Exposure Stress on the Intestinal Microflora of Weaned Tibetan Piglets DOI

Yuxuan He,

Mingbang Wei, Haibin Wu

и другие.

Microbial Pathogenesis, Год журнала: 2025, Номер unknown, С. 107135 - 107135

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Gut microbiota interact with breast cancer therapeutics to modulate efficacy DOI Creative Commons
Alana A. Arnone,

Katherine Ansley,

Arielle L. Heeke

и другие.

EMBO Molecular Medicine, Год журнала: 2025, Номер unknown

Опубликована: Янв. 16, 2025

Abstract The gut microbiome, or the community of microorganisms residing in gastrointestinal tract, has emerged as an important factor breast cancer etiology and treatment. Specifically, impact bacterial populations on therapeutic outcomes is emerging area research. microbiota’s role modifying pharmacokinetics chemotherapy endocrine-targeting therapies can alter drug efficacy toxicity profiles. In addition, microbiome’s capacity to regulate systemic inflammation immune responses may influence effectiveness both conventional immunotherapeutic strategies for treatment cancer. Overall, while bidirectional interactions between microbiome are still being studied, its increasingly recognized. Future research provide more definitive insights help develop personalized harness improve outcomes.

Язык: Английский

Процитировано

0
Gut Microbiota, Breast Cancer, and Neoadjuvant Therapy DOI

晨玥 夏

Advances in Clinical Medicine, Год журнала: 2025, Номер 15(03), С. 208 - 217

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Research Progress of Gut Microbiota in Immunity and Breast Cancer DOI

俊丽 任

Advances in Clinical Medicine, Год журнала: 2025, Номер 15(03), С. 184 - 191

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Comparison of Three DNA Isolation Methods and Two Sequencing Techniques for the Study of the Human Microbiota DOI Creative Commons
Julio Plaza‐Díaz, Mariana F. Fernández, Féderico García

и другие.

Life, Год журнала: 2025, Номер 15(4), С. 599 - 599

Опубликована: Апрель 4, 2025

Breast cancer is the most commonly diagnosed in women and second leading cause of female death. Altered interactions between host gut microbiota appear to play an influential role carcinogenesis. Several studies have shown different signatures patients with breast compared healthy women. Currently, there disagreement regarding DNA isolation sequencing methodologies for on human microbiota, given that they can influence interpretation results obtained. The goal this work was compare (1) three extraction strategies minimize impact DNA, (2) two (16S rRNA shotgun) identify discrepancies microbiome results. We made use tissue fecal samples from both who participated MICROMA study (reference NCT03885648). isolated by means mechanical lysis, trypsin, or saponin. amount eukaryotic using trypsin saponin methods lower lysis method (mechanical 89.11 ± 2.32%; method, 82.63 1.23%; 80.53 4.09%). In a predominance prokaryotic cells, such as feces, 16S advantageous approach. For other tissues, which are expected more complex microbial composition, need in-depth evaluation multifactorial interaction various components makes shotgun appropriate method. As evaluated, when than stool, convenient. samples, where contamination low, no prior treatment necessary.

Язык: Английский

Процитировано

0
Optimizing Cancer Treatment Through Gut Microbiome Modulation DOI Open Access
Kyuri Kim, Mingyu Lee, Yoojin Shin

и другие.

Cancers, Год журнала: 2025, Номер 17(7), С. 1252 - 1252

Опубликована: Апрель 7, 2025

The gut microbiome plays a pivotal role in modulating cancer therapies, including immunotherapy and chemotherapy. Emerging evidence demonstrates its influence on treatment efficacy, immune response, resistance mechanisms. Specific microbial taxa enhance checkpoint inhibitor while dysbiosis can contribute to adverse outcomes. Chemotherapy effectiveness is also influenced by composition, with engineered probiotics prebiotics offering promising strategies drug delivery reduce toxicity. Moreover, metabolites, such as short-chain fatty acids, systems have shown potential improve therapeutic responses. These findings underscore the importance of personalized microbiome-based approaches optimizing treatments.

Язык: Английский

Процитировано

0