Effects of Functional and Nutraceutical Foods in the Context of the Mediterranean Diet in Patients Diagnosed with Breast Cancer DOI Creative Commons
Giovanna Flore, Andrea Deledda, Mauro Lombardo

и другие.

Antioxidants, Год журнала: 2023, Номер 12(10), С. 1845 - 1845

Опубликована: Окт. 11, 2023

Several studies report that breast cancer survivors (BCS) tend to have a poor diet, as fruit, vegetable, and legume consumption is often reduced, resulting in decreased intake of nutraceuticals. Moreover, weight gain has been commonly described among BCS during treatment, increasing recurrence rate mortality. Improving lifestyle nutrition after the diagnosis BC may important benefits on patients’ general health specific clinical outcomes. The Mediterranean diet (MD), known for its multiple beneficial effects health, can be considered nutritional pool comprising several nutraceuticals: bioactive compounds foods with anti-inflammatory antioxidant effects. Recent scientific advances led identification nutraceuticals could amplify MD favorably influence gene expression these patients. Nutraceuticals postdiagnostic phase BC, including helping mitigate adverse chemotherapy radiotherapy. valid easy-to-follow option managing excess weight. aim this narrative review evaluate recent literature possible consuming functional nutraceutical framework BCS.

Язык: Английский

Effect of Regular Consumption of a Miraculin-Based Food Supplement on Taste Perception and Nutritional Status in Malnourished Cancer Patients: A Triple-Blind, Randomized, Placebo-Controlled Clinical Trial-CLINMIR Pilot Protocol DOI Open Access
Bricia López‐Plaza, Ángel Gil, Adrián Menéndez‐Rey

и другие.

Nutrients, Год журнала: 2023, Номер 15(21), С. 4639 - 4639

Опубликована: Ноя. 1, 2023

Taste disorders are common among cancer patients undergoing chemotherapy, with a prevalence ranging from 20% to 86%, persisting throughout treatment. This condition leads reduced food consumption, increasing the risk of malnutrition. Malnutrition is associated not only worse treatment efficacy and poor disease prognosis but also functional status quality life. The fruit Synsepalum dulcificum (Daniell), commonly known as miracle berry or fruit, contains miraculin, taste-modifying protein profound effects on taste perception. CLINMIR Protocol triple-blind, randomized, placebo-controlled clinical trial designed evaluate regular consumption supplement containing miraculin-based novel food, dried (DMB), perception (measured through electrogustometry) nutritional (evaluated GLIM Criteria) malnourished under active antineoplastic To this end, pilot study was 30 randomized divided into three arms (150 mg DMB + 150 freeze-dried strawberries, 300 DMB, placebo) for months. Throughout five main visits, an exhaustive assessment different parameters susceptible improvement will be conducted, including electrical chemical perception, smell morphofunctional assessment, diet, life, fatty acid profile erythrocytes, levels inflammatory cancer-associated cytokines, oxidative stress, antioxidant defense system, plasma metabolomics, saliva stool microbiota. primary anticipated result that distortion who consume report in translates increased intake, thereby ameliorating their mitigating risks. Additionally, aims pinpoint optimal dosage provides maximal benefits. protocol adheres SPIRIT 2013 Statement, which evidence-based recommendations widely endorsed international standard protocols. has been registered at platform Clinical Trials (NCT05486260).

Язык: Английский

Процитировано

9
OPTIMIZATION OF EXPERIMENTAL MODEL SYSTEMS FOR EVALUATING RECIPROCAL INFLUENCE OF BIFIDOBACTERIUM ANIMALIS AND HUMAN BREAST CANCER CELLS IN VITRO DOI Creative Commons
T. Kozak, O Lykhova, Tetiana Serhiichuk

и другие.

Experimental Oncology, Год журнала: 2024, Номер 45(4), С. 504 - 514

Опубликована: Фев. 3, 2024

Background. The development of human breast cancer (BC) is known to be closely related disturbances in the mammary gland microbiota. Bacteria genus Bifidobacterium are an important component normal microbiota and exert antitumor activity. molecular-biological mechanisms interaction between BC cells members remain poorly studied yet. aim this study was develop optimize experimental model system for co-cultivation with animalis vitro. Materials Methods. Human ВС MCF-7, T47D, MDA-MB-231 lines, as well live heat-inactivated bacteria subsp. lactis (B. animalis) were used research objects. growth kinetics viability B. presence different cell lines without them determined by both turbidimetry method seeding on elective nutrient medium. Glucose consumption lactate production bifidobacteria assessed biochemical methods. a standard colorimetric method. Results. complete DMEM medium showed patterns. indicators glucose confirm its physiological metabolic activity under conditions. did not affect duration phases cells’ population but contributed increase their counts. A significant decrease number all observed only after 48 h animalis. To achieve similar suppression viability, 10—30-fold higher counts heatinactivated required compared ones. Conclusions. optimal conditions living vitro have been identified.

Язык: Английский

Процитировано

3
Multiomics-based molecular subtyping based on the commensal microbiome predicts molecular characteristics and the therapeutic response in breast cancer DOI Creative Commons

Wenxing Qin,

Jia Li, Na Gao

и другие.

Molecular Cancer, Год журнала: 2024, Номер 23(1)

Опубликована: Май 10, 2024

Abstract The gut microbiota has been demonstrated to be correlated with the clinical phenotypes of diseases, including cancers. However, there are few studies on subtyping based microbiota, especially in breast cancer (BC) patients. Here, using machine learning methods, we analysed BC, colorectal (CRC), and gastric (GC) patients identify their shared metabolic pathways importance these development. Based microbiota-related pathways, human gene expression profile patient prognosis, established a novel BC system identified subtype called “challenging BC”. Tumours this have more genetic mutations complex immune environment than those other subtypes. A score index was proposed for in-depth analysis showed significant negative correlation prognosis. Notably, activation TPK1-FOXP3-mediated Hedgehog signalling pathway TPK1-ITGAE-mediated mTOR linked poor prognosis BC” high scores, as validated patient-derived xenograft (PDX) model. Furthermore, our effective predictors response current neoadjuvant therapy regimens, significantly negatively both treatment efficacy number cells. Therefore, findings provide valuable insights into predicting molecular characteristics responses

Язык: Английский

Процитировано

3
Effect of mastectomy on gut microbiota and its metabolites in patients with breast cancer DOI Creative Commons
Pingming Fan,

Linwei Ding,

Guankui Du

и другие.

Frontiers in Microbiology, Год журнала: 2024, Номер 15

Опубликована: Май 27, 2024

Background The relationship between gut microbiota and breast cancer has been extensively studied; however, changes in after surgery are still largely unknown. Materials methods A total of 20 patients with underwent routine open at the First Affiliated Hospital Hainan Medical College from 1 June 2022 to December 2022. Stool samples were collected undergoing mastectomy for preoperatively, 3 days later, 7 later postoperatively. stool subjected 16s rRNA sequencing. Results Surgery did not affect α-diversity microbiota. β-diversity composition microorganisms significantly affected by patients. Both linear discriminant analysis effect size (LEfSe) between-group differences showed that led a decrease abundance Firmicutes Lachnospiraceae an increase Proteobacteria Enterobacteriaceae . Moreover, 127 differential metabolites screened classified into 5 categories based on their changing trends. Kyoto Encyclopedia Genes Genomes (KEGG) enrichment significant phenylalanine metabolic pathway exogenous substance pathway. Eight characterized using ROC analysis. Conclusion Our study found altered metabolites, beneficial bacteria potentially harmful bacteria. This underscores importance enhanced postoperative management optimize

Язык: Английский

Процитировано

3
Effects of Functional and Nutraceutical Foods in the Context of the Mediterranean Diet in Patients Diagnosed with Breast Cancer DOI Creative Commons
Giovanna Flore, Andrea Deledda, Mauro Lombardo

и другие.

Antioxidants, Год журнала: 2023, Номер 12(10), С. 1845 - 1845

Опубликована: Окт. 11, 2023

Several studies report that breast cancer survivors (BCS) tend to have a poor diet, as fruit, vegetable, and legume consumption is often reduced, resulting in decreased intake of nutraceuticals. Moreover, weight gain has been commonly described among BCS during treatment, increasing recurrence rate mortality. Improving lifestyle nutrition after the diagnosis BC may important benefits on patients’ general health specific clinical outcomes. The Mediterranean diet (MD), known for its multiple beneficial effects health, can be considered nutritional pool comprising several nutraceuticals: bioactive compounds foods with anti-inflammatory antioxidant effects. Recent scientific advances led identification nutraceuticals could amplify MD favorably influence gene expression these patients. Nutraceuticals postdiagnostic phase BC, including helping mitigate adverse chemotherapy radiotherapy. valid easy-to-follow option managing excess weight. aim this narrative review evaluate recent literature possible consuming functional nutraceutical framework BCS.

Язык: Английский

Процитировано

8