Systemic Inflammation as the Health-Related Communication Tool Between the Human Host and Gut Microbiota in the Framework of Predictive, Preventive, and Personalized Medicine

Advances in predictive, preventive and personalised medicine, Год журнала: 2024, Номер unknown, С. 203 - 241

Опубликована: Янв. 1, 2024

Язык: Английский

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Prostate and gut: Any relationship? A narrative review on the available evidence and putative mechanisms

The Prostate, Год журнала: 2024, Номер unknown

Опубликована: Фев. 14, 2024

Abstract Background Gut microbiome is a community of microorganisms that lives in the human intestine and exerts various functions on host, including metabolic, immunoregulatory, control over cell proliferation. alterations have been associated with pathological conditions, such as diabetes mellitus, obesity, cardiovascular diseases. Gut‐prostate axis explained by association between gut quantitative functional along increased intestinal epithelial permeability prostatediseases. However, pathophysiological mechanisms clinical importance this are not completely clarified yet. Methods We conducted narrative review most relevant articles Medline (US National Library Medicine, Bethesda, MD, USA), Scopus (Elsevier, Amsterdam, The Netherlands) Web Science Core Collection (Thomson Reuters, Toronto, ON, Canada) databases. No chronological restrictions were applied, related papers published until December 2023 included. Results microbiota (GM) its metabolites capable modifying host androgen level, well prostate cancer (PCa) therapy response. Moreover, patients inflammatory bowel disease higher rates prostatitis‐like symptoms potential risk developing PCa. Conclusions There evidence interventions GM high to serve diagnostic therapeutic tools for diseases,

Язык: Английский

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Prostate Cancer and the Mevalonate Pathway

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(4), С. 2152 - 2152

Опубликована: Фев. 10, 2024

Antineoplastic therapies for prostate cancer (PCa) have traditionally centered around the androgen receptor (AR) pathway, which has demonstrated a significant role in oncogenesis. Nevertheless, it is becoming progressively apparent that therapeutic strategies must diversify their focus due to emergence of resistance mechanisms tumor employs when subjected monomolecular treatments. This review illustrates how dysregulation lipid metabolic pathway constitutes survival strategy adopted by tumors evade eradication efforts. Integrating this aspect into oncological management could prove valuable combating PCa.

Язык: Английский

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The bacterial microbiome and cancer: development, diagnosis, treatment, and future directions

Clinical and Experimental Medicine, Год журнала: 2024, Номер 25(1)

Опубликована: Ноя. 28, 2024

Abstract The term "microbiome" refers to the collection of bacterial species that reside in human body's tissues. Sometimes, it is used refer all microbial entities (bacteria, viruses, fungi, and others) which colonize body. It now generally acknowledged microbiome plays a critical role host's physiological processes general well-being. Changes structure and/or function (dysbiosis) are linked development many diseases including cancer. claim because their negatively charged membrane, cancer cells more vulnerable some bacteria than normal how link between these evolved has been refuted. Furthermore, relationship evident emerging field immunotherapy. In this narrative review, we detailed correlation presence/absence specific development, diagnosis, prognosis, treatment types colorectal, lung, breast, prostate addition, discussed mechanisms microbiome–cancer interactions genotoxin production, free radicals, modification signaling pathways host cells, immune modulation, modulation drug metabolism by microbiome. Future directions clinical application early detection, emphasizing on fecal transplantation, probiotics, prebiotics, biomarkers were also considered.

Язык: Английский

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Obesity, dietary interventions and microbiome alterations in the development and progression of prostate cancer

Frontiers in Immunology, Год журнала: 2025, Номер 15

Опубликована: Янв. 7, 2025

The role of the microbiome in prostate cancer is an emerging subject research interest. Certain lifestyle factors, such as obesity and diet, can also impact microbiome, which has been implicated many diseases, heart disease diabetes. However, this link yet to be explored detail context cancer. purpose review explore cross-talk between obesity, dietary interventions, alterations development progression Many possible mechanisms exist linking interventions gut produces metabolites that could play a oncogenesis, including short-chain fatty acids, cholesterol derivatives, folic acid. plays pivotal tumor microenvironment (TME), contributing inflammation, local tissue hypoxia, epithelial-mesenchymal transition. A bidirectional relationship exists certain diets enact changes its associated metabolites, outcomes. Cross-talk To further our understanding, future human studies should investigate incorporate assessment microbiome-derived cellular/immune TME.

Язык: Английский

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Microbial diversity and food safety in duck meat preservation: effects of nanoemulsion nutmeg seed extract with focus on proteobacteria and lactococcus

CyTA - Journal of Food, Год журнала: 2025, Номер 23(1)

Опубликована: Янв. 21, 2025

Язык: Английский

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Role of Microbiota‐Derived Metabolites in Prostate Cancer Inflammation and Progression

Cell Biochemistry and Function, Год журнала: 2025, Номер 43(2)

Опубликована: Янв. 31, 2025

Prostate cancer (PCa) is the most commonly detected malignancy in men worldwide. PCa a slow-growing with absence of symptoms at early stages. The pathogenesis has not been entirely understood including key risk factors related to development like diet and microbiota derived metabolites. Microbiota may influence host's immunological responses, inflammatory metabolic pathways, which be crucial for metastasis. Similarly, short-chain fatty acids, methylamines, hippurate, bile other metabolites generated by have potential roles inflammation progression cancer. Most studies focused on role their pathways involved chronic inflammation, tumor initiation, proliferation, progression. In summary, review discusses microbial-derived metabolite-built strategies PCa.

Язык: Английский

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Operationalizing Team Science at the Academic Cancer Center Network to Unveil the Structure and Function of the Gut Microbiome

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(6), С. 2040 - 2040

Опубликована: Март 17, 2025

Oncologists increasingly recognize the microbiome as an important facilitator of health well a contributor to disease, including, specifically, cancer. Our knowledge etiologies, mechanisms, and modulation states that ameliorate or promote cancer continues evolve. The progressive refinement adoption “omic” technologies (genomics, transcriptomics, proteomics, metabolomics) utilization advanced computational methods accelerate this evolution. academic center network, with its immediate access extensive, multidisciplinary expertise scientific resources, has potential catalyze research. Here, we review our current understanding role gut in prevention, predisposition, response therapy. We underscore promise operationalizing network uncover structure function microbiome; highlight unique microbiome-related expert resources available at City Hope Comprehensive Cancer Center example team science achieve novel clinical discovery.

Язык: Английский

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Gut microbiome, dietary habits, and prostate cancer: a two-step Mendelian randomization revealing the causal associations

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Март 23, 2025

Recent studies suggest that diet fizzy drinks may contribute to prostate cancer (PCa) development. However, the causal effects between and PCa whether gut microbiota (GM) act as a mediator remain unclear. We conducted two-sample Mendelian Randomization (MR) analyses utilizing large-scale genome-wide association (GWAS) data from UK Biobank, MiBioGen consortium, PCa-related datasets. The inverse-variance weighted (IVW) method was used evaluate of GM dietary preferences on risk. A mediation analysis performed investigate mediates relationship factors Diet drink consumption causally associated with reduced risk (OR = 0.83, 95% CI: 0.70–0.99, P 0.041) decreased abundance PCa-risk-related taxa (Negativicutes Selenomonadales). Mediation did not reveal statistically significant effect, proportion 16% (95% − 0.06–0.37, 0.13). Consumption reduce PCa, potentially through modulation GM; however, further are required confirm these findings clarify underlying mechanisms.

Язык: Английский

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Current Trends and Challenges of Microbiome Research in Prostate Cancer

Current Oncology Reports, Год журнала: 2024, Номер 26(5), С. 477 - 487

Опубликована: Апрель 4, 2024

Язык: Английский

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