Retinal Alterations Predict Early Prodromal Signs of Neurodegenerative Disease

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(3), С. 1689 - 1689

Опубликована: Янв. 30, 2024

Neurodegenerative diseases are an increasingly common group of that occur late in life with a significant impact on personal, family, and economic life. Among these, Alzheimer’s disease (AD) Parkinson’s (PD) the major disorders lead to mild severe cognitive physical impairment dementia. Interestingly, those may show onset prodromal symptoms early after middle age. Commonly, evaluation these neurodegenerative is based detection biomarkers, where functional structural magnetic resonance imaging (MRI) have shown central role revealing or phases, although it can be expensive, time-consuming, not always available. The aforementioned visual system due pathophysiological mechanisms shared between eye brain. In disease, α-synuclein deposition retinal cells, as well dopaminergic neurons substantia nigra, alters cortex function, resulting modifications field. Similarly, modified by neurofibrillary tangles neuritic amyloid β plaques typically seen brain, this reflect accumulation biomarkers retina during stages postmortem retinas AD patients. light, ophthalmic neurodegeneration could become cost-effective method for diagnosis diseases, overcoming limitations deep This analysis commonly used practice, interest has risen recent years. review will discuss relationship degeneration, highlighting how represent noninvasive straightforward diseases.

Язык: Английский

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The role of oxidative stress in the pathogenesis of ocular diseases: an overview

Molecular Biology Reports, Год журнала: 2024, Номер 51(1)

Опубликована: Март 27, 2024

Язык: Английский

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CEP-1347 Dually Targets MDM4 and PKC to Activate p53 and Inhibit the Growth of Uveal Melanoma Cells

Cancers, Год журнала: 2023, Номер 16(1), С. 118 - 118

Опубликована: Дек. 25, 2023

Uveal melanoma (UM) is among the most common primary intraocular neoplasms in adults, with limited therapeutic options for advanced/metastatic disease. Since UM characterized by infrequent p53 mutation coupled overexpression of MDM4, a major negative regulator p53, we aimed to investigate this study effects on cells CEP-1347, novel MDM4 inhibitor known safety profile humans. We also examined impact CEP-1347 protein kinase C (PKC) pathway, play pivotal role cell growth. High-grade lines were used analyze genetic and pharmacological inhibition PKC, respectively, as well those treatment, expression viability. The results showed that, at its clinically relevant concentrations, reduced not only but PKC activity, activated effectively inhibited growth cells. Importantly, whereas either or activity alone failed efficiently activate inhibit growth, both resulted effective activation These data suggest that there exists hitherto unrecognized interaction between inactivate p53-dependent control which dually targets could therefore be promising candidate treatment UM.

Язык: Английский

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Insights into ocular cancer oncogenesis (Review)

World Academy of Sciences Journal, Год журнала: 2024, Номер 7(2)

Опубликована: Дек. 27, 2024

Ocular cancer refers to a cancerous growth in any part of the eye. primarily manifests as one four types: Uveal melanoma, conjunctival retinoblastoma, or ocular surface squamous neoplasia. It can arise three key areas eye: The orbit, adnexal structure and eyeball. In cancer, oncogenes are activated from proto‑oncogenes. An oncogene is malfunctioning gene cell caused by mutation fusion (a proto‑oncogene) overexpression. There certain specific implicated such retinoblastoma (Rb) gene, guanine nucleotide binding protein alpha 11 (GNA11), G subunit Q (GNAQ) tumor 53. Of note, >90% instances uveal melanoma activating mutations GNA11 GNAQ. Oncogene activation occurs through several mechanisms involving genetic, epigenetic environmental variables. Biomarkers trigger this type oncogene. A biomarker quantifiable trait indicator that be used test measure biological functioning, disease states, therapeutic responses. Certain target therapies (such radiation therapy, surgery, combination immunotherapy) treatment. present review aimed provide more thorough understanding involvement melanoma. hoped may aid treatment forms cancer. Understanding mutated assist discovery cure for particular gene.

Язык: Английский

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New N-substituted 2,4,5-triarylimidazolines: synthesis and antitumor activity

Russian Chemical Bulletin, Год журнала: 2024, Номер 73(12), С. 3732 - 3739

Опубликована: Дек. 1, 2024

Язык: Английский

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Pathogenesis and Advances in the Clinical Management of Pterygium

Advances in Clinical Medicine, Год журнала: 2023, Номер 13(11), С. 18209 - 18216

Опубликована: Янв. 1, 2023

Язык: Английский

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