Molecular Therapy — Nucleic Acids,
Год журнала:
2024,
Номер
35(3), С. 102310 - 102310
Опубликована: Авг. 15, 2024
Viral
infections
are
one
of
the
leading
causes
death
in
world.
One
main
challenge
fighting
against
these
diseases
is
unavailability
effective
eradicating
drugs
and
specific
treatments.
Nanocarriers
aptamer-decorated
nanocarriers
designed
to
attach
many
targets,
including
viral
particles.
By
lowering
infectivity
attachment
capability,
they
add
therapeutic
values
even
without
containing
antiviral
drugs.
Nevertheless,
nanoparticles
(NPs)
with
encapsulated
can
display
extra
effects.
Furthermore,
it
has
been
shown
that
aptamers
bind
particles
nanocarriers,
presenting
promising
approaches
for
identification
viruses
treatment
infections.
Although
there
no
satisfying
literature
revealing
strong
potential
nanotechnology
COVID-19,
following
information
provide
new
perspectives
upcoming
investigations
pertaining
developing
aptamer-nanocarrier
agents
COVID-19.
Pharmaceutics,
Год журнала:
2024,
Номер
16(6), С. 709 - 709
Опубликована: Май 24, 2024
Of
all
the
numerous
nanosized
extracellular
vesicles
released
by
a
cell,
endosomal-originated
exosomes
are
increasingly
recognized
as
potential
therapeutics,
owing
to
their
inherent
stability,
low
immunogenicity,
and
targeted
delivery
capabilities.
This
review
critically
evaluates
transformative
of
exosome-based
modalities
across
pharmaceutical
precision
medicine
landscapes.
Because
precise
biomolecular
cargo
delivery,
posited
ideal
candidates
in
drug
enhancing
regenerative
strategies,
advancing
diagnostic
technologies.
Despite
significant
market
growth
projections
exosome
therapy,
its
utilization
is
encumbered
substantial
scientific
regulatory
challenges.
These
include
lack
universally
accepted
protocols
for
isolation
complexities
associated
with
navigating
environment,
particularly
guidelines
set
forth
U.S.
Food
Drug
Administration
(FDA).
presents
comprehensive
overview
current
research
trajectories
aimed
at
addressing
these
impediments
discusses
prospective
advancements
that
could
substantiate
clinical
translation
exosomal
therapies.
By
providing
analysis
both
capabilities
hurdles
therapeutic
applications,
this
article
aims
inform
direct
future
paradigms,
thereby
fostering
integration
systems
into
mainstream
practice.
Abstract
DNA
nanostructures
exhibit
versatile
geometries
and
possess
sophisticated
capabilities
not
found
in
other
nanomaterials.
They
serve
as
customizable
nanoplatforms
for
orchestrating
the
spatial
arrangement
of
molecular
components,
such
biomolecules,
antibodies,
or
synthetic
This
is
achieved
by
incorporating
oligonucleotides
into
design
nanostructure.
In
realm
drug
delivery
to
cancer
cells,
there
a
growing
interest
active
targeting
assays
enhance
efficacy
selectivity.
The
approach
involves
“key‐lock”
mechanism
where
carrier,
through
its
ligand,
recognizes
specific
receptors
on
tumor
facilitating
release
drugs.
Various
nanostructures,
including
origami,
Tetrahedral,
nanoflower,
cruciform,
nanostar,
nanocentipede,
nanococklebur,
can
traverse
lipid
layer
cell
membrane,
allowing
cargo
nucleus.
Aptamers,
easily
formed
vitro,
are
recognized
their
targeted
due
high
selectivity
targets
low
immunogenicity.
review
provides
comprehensive
overview
recent
advancements
formation
modification
aptamer‐modified
within
systems.
Pharmaceutics,
Год журнала:
2025,
Номер
17(3), С. 277 - 277
Опубликована: Фев. 20, 2025
Increasing
evidence
shows
that
a
very
small
population
of
cancer
stem
cells
(CSCs)
is
responsible
for
recurrence,
drug
resistance,
and
metastasis.
CSCs
usually
reside
in
hypoxic
tumor
regions
are
characterized
by
high
tumorigenicity.
Their
inaccessible
nature
allows
them
to
avoid
the
effects
conventional
treatments
such
as
chemotherapy,
radiotherapy,
surgery.
In
addition,
chemo-
radiotherapy
potentially
toxic
could
help
spread
survive.
New
therapeutic
targets
against
sought,
including
different
signaling
pathways
distinct
cell
surface
markers.
Recent
advances
nanotechnology
have
provided
hope
development
new
avenues
eradicate
CSCs.
this
review,
we
present
newly
discovered
nanoparticles
can
be
co-loaded
with
an
apoptosis-inducing
agent
or
differentiation-inducing
agent,
stability,
cellular
penetration,
release.
We
also
summarize
molecular
characteristics
their
survival
maintenance.
Controlled
release
targeting
aims
reduce
stemness-related
suppress
growth,
prevent
relapse
metastases.
European journal of medical research,
Год журнала:
2025,
Номер
30(1)
Опубликована: Апрель 17, 2025
Understanding
the
core
principles
of
ovarian
cancer
has
been
significantly
improved
through
exploration
Ferroptosis,
a
type
cell
death
triggered
by
iron
that
leads
to
an
increase
in
lipid
peroxides.
Current
research
shed
light
on
critical
functions
non-coding
RNAs,
such
as
circRNAs,
lncRNAs,
and
miRNAs,
regulating
ferroptosis
cancer.
The
aim
this
paper
is
comprehensively
analyze
how
ncRNAs
influence
development
cells.
In-depth
undertaken
understand
intricate
ways
which
regulate
essential
elements
ferroptosis,
including
management
peroxidation
levels.
We
also
investigate
their
significant
involvement
progression
cellular
demise.
It
should
be
emphasized
can
impact
synthesis
crucial
proteins,
GPX4,
key
contributor
defense
against
oxidation,
ACSL4,
involved
formation.
In
addition,
we
examine
correlation
between
well-known
pathways
associated
with
oxidative
stress
death.
consequences
these
discoveries
are
noteworthy,
since
focusing
particular
could
potentially
render
cells
more
vulnerable
effectively
combating
drug
resistance
problems.
This
discussion
highlights
growing
significance
governing
potential
useful
biomarkers
treatment
targets
for
intend
promote
additional
into
controlling
based
current
findings,
ultimate
goal
informing
targeted
therapeutic
strategies
improving
long-term
outcomes
individuals
suffering
from
OC.
