International Journal of Hyperthermia, Год журнала: 2024, Номер 41(1)
Опубликована: Ноя. 3, 2024
Introduction Hyperthermia (HT) at temperatures between 39 °C and 44 is utilized as an adjunctive cancer therapy, serving potent radio- chemosensitizer. Its effectiveness in treating solid malignancies has been well established. This raises the question of whether HT can also benefit patients with nonsolid tumors, such lymphomas.
Язык: Английский
Life Sciences, Год журнала: 2024, Номер 352, С. 122899 - 122899
Опубликована: Июль 9, 2024
This comprehensive review provides an in-depth analysis of how nanotechnology has revolutionized cancer theragnostic, which combines diagnostic and therapeutic methods to customize treatment. The study examines the unique attributes, uses, difficulties linked different types nanoparticles, including gold, iron oxide, silica, Quantum dots, Carbon nanotubes, liposomes, in context In addition, paper progression nanotheranostics, emphasizing its uses precise medication administration, photothermal therapy, sophisticated such as MRI, CT, fluorescence imaging. Moreover, article highlights capacity nanoparticles improve effectiveness drugs, reduce overall toxicity body, open up new possibilities for treating by releasing drugs a controlled manner targeting specific areas. Furthermore, it tackles concerns regarding compatibility their potential harmful effects, significance continuous nanotherapeutic use medical treatments. finishes outlining future applications predictive oncology customized medicine.
Язык: Английский
Процитировано
60
Health Sciences Review, Год журнала: 2025, Номер unknown, С. 100212 - 100212
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Molecules, Год журнала: 2024, Номер 29(17), С. 4280 - 4280
Опубликована: Сен. 9, 2024
In this review we explore innovative approaches in the treatment of hematologic cancers by combining various therapeutic modalities. We discuss synergistic potential inhibitors targeting different cellular pathways with immunotherapies, molecular therapies, and hormonal therapies. Examples include PI3K proteasome inhibitors, NF-κB immunotherapy checkpoint neddylation therapies tumor microenvironment. Additionally, use small molecules peptide cancer treatment. These multidimensional combinations present promising strategies for enhancing efficacy overcoming resistance mechanisms. However, further clinical research is required to validate their effectiveness safety profiles patients.
Язык: Английский
Процитировано
5
Journal of Biophotonics, Год журнала: 2025, Номер unknown
Опубликована: Фев. 6, 2025
ABSTRACT Photothermal therapy (PTT) offers a minimally invasive approach for cancer treatment, using light energy to selectively heat and destroy cells. Success in PTT depends on efficient, stable, biocompatible photothermal agents. This study investigates polypyrrole@gold nanocomposites (PPy@Au NCs) as agents combined with polarized polychromatic low‐energy (PPLEL) target tumors limit disease progression. In vivo experiments Ehrlich carcinoma‐bearing female Swiss albino mice demonstrated that PPy@Au NCs accumulated tumor tissue and, when activated by PPLEL, generated sufficient effective ablation. enhanced treatment efficacy presented cost‐effective solution due the affordability of both nanocomposite source. Histopathological analysis confirmed significant reduction, suggesting this synergistic combination promising strategy. Findings support further research potential clinical applications therapy.
Язык: Английский
Процитировано
0
International Communications in Heat and Mass Transfer, Год журнала: 2025, Номер 164, С. 108895 - 108895
Опубликована: Март 29, 2025
Язык: Английский
Процитировано
0
Frontiers in Pharmacology, Год журнала: 2025, Номер 16
Опубликована: Фев. 20, 2025
Renal cancer is known for its aggressive progression and resistance to standard treatments, underscoring the need novel therapeutic strategies. This study explores potential of combining 6-shogaol (6-SHO), a bioactive compound derived from ginger (Zingiber officinale), with hyperthermia enhance anticancer efficacy in ACHN renal cells. cells were treated 6-SHO exposed hyperthermic conditions. We evaluated combined effects on apoptosis, cell cycle arrest, proliferation, as well role reactive oxygen species (ROS) heat shock proteins (HSPs) mediating these responses. The combination significantly increased induced G2/M phase reduced proliferation more effectively than either treatment alone. ROS played critical effects, modulation HSPs factor 1 (HSF1) further disrupting survival mechanisms. These findings highlight synergistic approach treatment, supporting research clinical evaluation.
Язык: Английский
Процитировано
0
Materials, Год журнала: 2024, Номер 17(24), С. 6127 - 6127
Опубликована: Дек. 14, 2024
Nanocomposites based on Fe3O4 and carbonaceous nanoparticles (CNPs), including carbon nanotubes (CNTs) graphene derivatives (graphene oxide (GO) reduced (RGO)), such as Fe3O4@GO, Fe3O4@RGO, Fe3O4@CNT, have demonstrated considerable potential in a number of health applications, tissue regeneration innovative cancer treatments hyperthermia (HT). This is due to their ability transport drugs generate localized heat under the influence an alternating magnetic field Fe3O4. Despite promising CNTs drug delivery systems, use biological applications hindered by challenges related dispersion physiological media particle agglomeration. Hence, solid foundation has been established for integration various synthesis techniques these nanocomposites, with wet co-precipitation method being most prevalent. Moreover, dimensions morphology composite are directly correlated value saturation, thus influencing efficiency other significant biomedical applications. The current demand this type material loading larger quantity within hybrid structure carrier, objective releasing amount into tumor cells. A second refers biocompatibility carrier its capacity permeate cell membranes, well processes occurring carriers. main paper review methods used prepare hybrids CNPs, GO, RGO, CNTs, examinate role formation correlation between morphology, dimensions, optical/magnetic properties.
Язык: Английский
Процитировано
1
International Journal of Pharmaceutics, Год журнала: 2024, Номер 668, С. 124952 - 124952
Опубликована: Ноя. 14, 2024
Язык: Английский
Процитировано
0
Cancers, Год журнала: 2024, Номер 16(16), С. 2848 - 2848
Опубликована: Авг. 15, 2024
Pancreatic cancer is a significant challenge in oncology due to its aggressive nature and complex management, leading high mortality rates dismally low 5-year survival rate. Approximately 85% of cases manifest as adenocarcinoma, while endocrine tumors constitute less than 5%. Borderline resectable locally advanced pancreatic cancers are particularly difficult treat vascular involvement, which complicates complete resections increases morbidity. Various therapeutic modalities aim overcome these challenges improve patient outcomes. Traditionally, upfront surgery was the standard for tumors, with multimodal chemotherapy being central treatment. Understanding surgical anatomy pivotal enhancing outcomes survival. Resectability several when seeking achieve R0 resections, borderline tumors. classification systems-the MD Anderson criteria, NCCN AHPA/SSAT/SSO consensus statement, Alliance definition-assess tumor involvement major blood vessels, first systems broadly accepted. Vascular staging integration also important, Ishikawa system using preoperative imaging assess venous involvement. Furthermore, neoadjuvant therapy enhances treatment effectiveness by addressing micro-metastatic disease early, increasing resection chances, downstaging optimal surgery. Insights from Fox Chase Cancer Center's approach highlight importance multidisciplinary strategy advancing improving prognosis. This commentary, inspired Dr. Sanjay S. Reddy's Keynote Conference during MedNews week, highlights current advancements ongoing cancer, emphasizing need comprehensive,
Язык: Английский
Процитировано
0
International Journal of Hyperthermia, Год журнала: 2024, Номер 41(1)
Опубликована: Ноя. 3, 2024
Introduction Hyperthermia (HT) at temperatures between 39 °C and 44 is utilized as an adjunctive cancer therapy, serving potent radio- chemosensitizer. Its effectiveness in treating solid malignancies has been well established. This raises the question of whether HT can also benefit patients with nonsolid tumors, such lymphomas.
Язык: Английский
Процитировано
0