Review of preclinical data on hyperthermia treatment in lymphomas and its potential for clinical application DOI Creative Commons

Moritz V. Scharr,

Frédérik Damm, P Krahl

et al.

International Journal of Hyperthermia, Journal Year: 2024, Volume and Issue: 41(1)

Published: Nov. 3, 2024

Introduction Hyperthermia (HT) at temperatures between 39 °C and 44 is utilized as an adjunctive cancer therapy, serving potent radio- chemosensitizer. Its effectiveness in treating solid malignancies has been well established. This raises the question of whether HT can also benefit patients with nonsolid tumors, such lymphomas.

Language: Английский

Nanoparticles in cancer theragnostic and drug delivery: A comprehensive review DOI Creative Commons

Alshayma N. Al-Thani,

Asma Ghafoor Jan,

Mohamed Abbas

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 352, P. 122899 - 122899

Published: July 9, 2024

This comprehensive review provides an in-depth analysis of how nanotechnology has revolutionized cancer theragnostic, which combines diagnostic and therapeutic methods to customize treatment. The study examines the unique attributes, uses, difficulties linked different types nanoparticles, including gold, iron oxide, silica, Quantum dots, Carbon nanotubes, liposomes, in context In addition, paper progression nanotheranostics, emphasizing its uses precise medication administration, photothermal therapy, sophisticated such as MRI, CT, fluorescence imaging. Moreover, article highlights capacity nanoparticles improve effectiveness drugs, reduce overall toxicity body, open up new possibilities for treating by releasing drugs a controlled manner targeting specific areas. Furthermore, it tackles concerns regarding compatibility their potential harmful effects, significance continuous nanotherapeutic use medical treatments. finishes outlining future applications predictive oncology customized medicine.

Language: Английский

Citations

82
Revolution in Cancer Treatment Methods: Perspective Review of Factors Affecting the Final Results of Nanoparticles Used in Magnetic Fluid Hyperthermia DOI Creative Commons

parisa oskoui,

Maryam Rezvani

Health Sciences Review, Journal Year: 2025, Volume and Issue: unknown, P. 100212 - 100212

Published: Jan. 1, 2025

Language: Английский

Citations

2
Promising Therapeutic Strategies for Hematologic Malignancies: Innovations and Potential DOI Creative Commons
Jan Jakub Lica, Bhaskar Pradhan, Kawthar Safi

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(17), P. 4280 - 4280

Published: Sept. 9, 2024

In this review we explore innovative approaches in the treatment of hematologic cancers by combining various therapeutic modalities. We discuss synergistic potential inhibitors targeting different cellular pathways with immunotherapies, molecular therapies, and hormonal therapies. Examples include PI3K proteasome inhibitors, NF-κB immunotherapy checkpoint neddylation therapies tumor microenvironment. Additionally, use small molecules peptide cancer treatment. These multidimensional combinations present promising strategies for enhancing efficacy overcoming resistance mechanisms. However, further clinical research is required to validate their effectiveness safety profiles patients.

Language: Английский

Citations

8
Advances and applications of hyperthermia in tumor therapy: Mechanisms, techniques, and clinical integration DOI

Cui-Hua Gu,

Jinzhong Zhang, Jinsong Zeng

et al.

International Communications in Heat and Mass Transfer, Journal Year: 2025, Volume and Issue: 164, P. 108895 - 108895

Published: March 29, 2025

Language: Английский

Citations

1
Enhanced Photothermal Tumor Ablation Using Polypyrrole‐Gold Nanocomposites Activated by Polarized Polychromatic Low‐Energy Light: An In Vivo Study DOI Open Access
Jilan S. Ibrahim,

Neamat Hanafi,

Mahmoud A. Sliem

et al.

Journal of Biophotonics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

ABSTRACT Photothermal therapy (PTT) offers a minimally invasive approach for cancer treatment, using light energy to selectively heat and destroy cells. Success in PTT depends on efficient, stable, biocompatible photothermal agents. This study investigates polypyrrole@gold nanocomposites (PPy@Au NCs) as agents combined with polarized polychromatic low‐energy (PPLEL) target tumors limit disease progression. In vivo experiments Ehrlich carcinoma‐bearing female Swiss albino mice demonstrated that PPy@Au NCs accumulated tumor tissue and, when activated by PPLEL, generated sufficient effective ablation. enhanced treatment efficacy presented cost‐effective solution due the affordability of both nanocomposite source. Histopathological analysis confirmed significant reduction, suggesting this synergistic combination promising strategy. Findings support further research potential clinical applications therapy.

Language: Английский

Citations

0
Synergistic effects of 6-shogaol and hyperthermia on ACHN renal cancer cells: modulation of ROS and heat shock pro-teins in cancer therapy DOI Creative Commons
Chae Ryeong Ahn, Seung Ho Baek

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 20, 2025

Renal cancer is known for its aggressive progression and resistance to standard treatments, underscoring the need novel therapeutic strategies. This study explores potential of combining 6-shogaol (6-SHO), a bioactive compound derived from ginger (Zingiber officinale), with hyperthermia enhance anticancer efficacy in ACHN renal cells. cells were treated 6-SHO exposed hyperthermic conditions. We evaluated combined effects on apoptosis, cell cycle arrest, proliferation, as well role reactive oxygen species (ROS) heat shock proteins (HSPs) mediating these responses. The combination significantly increased induced G2/M phase reduced proliferation more effectively than either treatment alone. ROS played critical effects, modulation HSPs factor 1 (HSF1) further disrupting survival mechanisms. These findings highlight synergistic approach treatment, supporting research clinical evaluation.

Language: Английский

Citations

0
Hyperthermic Intrathoracic Chemoperfusion and the Role of Adjunct Immunotherapy for the Treatment of Pleural Mesothelioma DOI Creative Commons

Shengchun Kong,

Zihan Feng, Sang-Min Kim

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(5), P. 678 - 678

Published: May 7, 2025

Pleural mesothelioma (PM) is an aggressive cancer originating from the mesothelial lining of pleura, with a rising global incidence since mid-20th century due to asbestos and erionite exposure. PM accounts for 80–90% all cases histologically classified into three subtypes—epithelioid, sarcomatoid, biphasic— epithelioid carrying most favorable prognosis. Despite advances in surgery, chemotherapy, radiotherapy, immunotherapy, prognosis remains poor, necessitating more effective, multimodal strategies. Hyperthermic intrathoracic chemoperfusion (HITHOC) has emerged as promising adjunct cytoreductive surgery by delivering heated chemotherapy directly pleural cavity, potentially improving survival—especially patients PM. Combining HITHOC post-surgical immunotherapy represents novel approach enhancing both local systemic anti-tumor responses targeting microscopic disease distant metastases. This review explores surgical outcomes after PM, therapeutic synergy ongoing clinical trials evaluating this strategy, its implications future patient care.

Language: Английский

Citations

0
Advanced functionalized chitosan nanocomposites for hyperthermia-based cancer therapy DOI
Mohamed J. Saadh, Jayanti Makasana,

Suhas Ballal

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(6)

Published: May 12, 2025

Language: Английский

Citations

0
Magnetite Nanoparticle Photothermal Therapy in a Pancreatic Tumor-on-Chip: A Dual-Action Approach Targeting Cancer Cells and their Microenvironment DOI

Anastasiia Dubrova,

Charles Cavaniol, Aurore Van de Walle

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: May 21, 2025

The application of magnetite nanoparticles (MagNPs) for photothermal therapy (MagNP-PTT) has recently expanded to cancer treatment. This study introduces MagNP-PTT in a tumor-on-a-chip model target highly aggressive pancreatic ductal adenocarcinoma (PDAC). A tumor-on-chip system was developed using PANC-1 PDAC cells embedded collagen type I extracellular matrix and cultured 1 week form tumor spheroids. platform offers framework applying PTT that aims mimic the native microenvironment. MagNPs efficiently penetrate spheroids, achieving controlled heating via near-infrared (NIR) light. By adjusting nanoparticle concentration laser power, temperature increments 2 °C between 38-48 were established. Temperatures above 44 significantly increased cell death, while lower temperatures allowed partial recovery. Beyond inducing altered triggered slight epithelial-mesenchymal transition marked by vimentin expression. These findings highlight as dual-action therapy, targeting both their microenvironment, offering an alternative approach overcoming stromal barriers

Language: Английский

Citations

0
Combination of gold nanoparticles with near-infrared light as an alternative approach for melanoma management DOI Creative Commons
Joana Lopes, Carla Rodrigues, Ana Godinho‐Santos

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 668, P. 124952 - 124952

Published: Nov. 14, 2024

Language: Английский

Citations

1