Extracellular Matrix Components and Mechanosensing Pathways in Health and Disease
Biomolecules,
Год журнала:
2024,
Номер
14(9), С. 1186 - 1186
Опубликована: Сен. 20, 2024
Glycosaminoglycans
(GAGs)
and
proteoglycans
(PGs)
are
essential
components
of
the
extracellular
matrix
(ECM)
with
pivotal
roles
in
cellular
mechanosensing
pathways.
GAGs,
such
as
heparan
sulfate
(HS)
chondroitin
(CS),
interact
various
cell
surface
receptors,
including
integrins
receptor
tyrosine
kinases,
to
modulate
responses
mechanical
stimuli.
PGs,
comprising
a
core
protein
covalently
attached
GAG
chains,
serve
dynamic
regulators
tissue
mechanics
behavior,
thereby
playing
crucial
role
maintaining
homeostasis.
Dysregulation
GAG/PG-mediated
pathways
is
implicated
numerous
pathological
conditions,
cancer
inflammation.
Understanding
intricate
mechanisms
by
which
GAGs
PGs
forces
holds
promise
for
developing
novel
therapeutic
strategies
targeting
mechanotransduction
disease.
This
comprehensive
overview
underscores
importance
key
mediators
homeostasis
their
potential
targets
mitigating
mechano-driven
pathologies,
focusing
on
Язык: Английский
Tumor Microenvironment: Nurturing Cancer Cells for Immunoevasion and Druggable Vulnerabilities for Cancer Immunotherapy
Cancer Letters,
Год журнала:
2024,
Номер
611, С. 217385 - 217385
Опубликована: Дек. 6, 2024
Язык: Английский
Deciphering the Interplay of the PD‐L1/MALT1/miR‐200a Axis During Lung Cancer Development
Biotechnology and Applied Biochemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 5, 2025
Abstract
Lung
cancer
remains
a
leading
cause
of
cancer‐related
mortality
worldwide.
Our
study
investigates
the
involvement
PD‐L1/MALAT1/miR‐200a‐3p
axis
in
lung
tumor
progression
using
murine
model
carcinogenesis.
tumors
were
induced
rats,
which
divided
into
groups
and
sacrificed
at
different
stages
development.
A
histopathological
examination
was
performed
to
assess
progression.
Immunohistochemistry
applied
evaluate
expression
Ki‐67
programmed
death‐ligand
1
(PD‐L1).
The
level
carcinoembryonic
antigen
(CEA)
analysis
metastasis‐associated
adenocarcinoma
transcript
(MALAT1),
miR‐200a‐3p,
zinc
finger
E‐box
binding
homeobox
(ZEB1)
evaluated
for
each
stage
induction.
Immunohistochemical
demonstrated
progressive
upregulation
proliferative
marker
immune
checkpoint
protein
PD‐L1
during
induction
process,
indicative
enhanced
proliferation
evasion.
Additionally,
CEA
levels
revealed
increase
across
stages,
with
significant
advanced
highlighting
its
clinical
relevance
as
biomarker
Expression
dynamic
MALAT1
downregulation
miR‐200a
induction,
correlated
elevated
expression,
suggesting
that
negative
correlation
between
is
involved
development
tumors.
ZEB1
exhibited
notable
consistent
association
aggressive
cancer.
findings
underscore
interplay
molecular
pathways
potential
diagnostic
therapeutic
implications
axis.
Язык: Английский
Advances in non-small cell lung cancer mechanomedicine: deciphering the signaling networks that govern tumor-TME interactions
Journal of Experimental & Clinical Cancer Research,
Год журнала:
2024,
Номер
43(1)
Опубликована: Ноя. 30, 2024
Abstract
Cells
from
the
tumor
microenvironment
(TME)
interact
with
cells
in
non-small
cell
lung
cancer
(NSCLC)
to
form
a
reciprocal
crosstalk
which
influences
growth,
proliferation,
metastasis
and
multidrug
response.
This
is
modulated
by
TME
mechanical
inputs,
elicit
processes
of
mechanosensing
mechanotransduction.
Recent
advances
unveiling
these
signaling
networks
establish
interdisciplinary
field
mechanomedicine
exploit
emerging
diagnostic,
predictive
therapeutic
tools
for
more
effective
NSCLC
treatments.
Язык: Английский
Mechanotransduction Circuits in Human Pathobiology
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(7), С. 3816 - 3816
Опубликована: Март 29, 2024
It
is
widely
acknowledged
that
mechanical
forces
exerted
throughout
the
human
body
are
critical
for
cellular
and
tissue
homeostasis
[...].
Язык: Английский
Harnessing Tumor Mechanobiology in NSCLC Treatment
Archivos de Bronconeumología,
Год журнала:
2024,
Номер
60(8), С. 523 - 525
Опубликована: Апрель 19, 2024
Язык: Английский
DDX18 Facilitates the Tumorigenesis of Lung Adenocarcinoma by Promoting Cell Cycle Progression through the Upregulation of CDK4
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(9), С. 4953 - 4953
Опубликована: Май 1, 2024
Lung
adenocarcinoma
(LUAD)
is
the
most
prevalent
and
aggressive
subtype
of
lung
cancer,
exhibiting
a
dismal
prognosis
with
five-year
survival
rate
below
5%.
DEAD-box
RNA
helicase
18
(
Язык: Английский
Exploiting tumor mechanomedicine for lung cancer treatment
Cancer Letters,
Год журнала:
2024,
Номер
604, С. 217229 - 217229
Опубликована: Сен. 12, 2024
Язык: Английский
Targeting Nanoparticles to Lung Cancer-derived A549 Cells Based on Changes on Interstitial Stiffness in Biomimetic Models
iScience,
Год журнала:
2024,
Номер
27(10), С. 111015 - 111015
Опубликована: Сен. 23, 2024
Язык: Английский
Plasma-Activated Medium Inhibited the Proliferation and Migration of Non-Small Cell Lung Cancer A549 Cells in 3D Culture
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(24), С. 13262 - 13262
Опубликована: Дек. 10, 2024
Lung
cancer
is
the
most
common
type
of
malignant
tumor
worldwide.
Plasma-activated
medium
(PAM)
an
innovative
treatment
method
that
has
received
considerable
scientific
attention.
The
objective
this
study
to
evaluate
effects
PAM
on
anti-tumor
characteristics
non-small
cell
lung
(NSCLC)
cells
in
two-dimensional
(2D)
and
three-dimensional
(3D)
cultures.
proliferative
migratory
capabilities
A549
2D
3D
cultures
were
assessed
using
MTT,
migration,
invasion
assays,
cycle,
respectively.
also
investigated
impact
changes
content
intracellular
extracellular
reactive
species
analyzed
protein
expression
Western
Blot
method.
inhibited
viability,
abilities
both
cultures,
suppressed
epithelial–mesenchymal
transition
(EMT)
process,
downregulated
RAS/ERK
signaling
pathway,
which
effectively
spheroid
formation.
Additionally,
effect
was
mediated
through
ROS-induced
oxidative
reactions,
exhibited
greater
cytotoxicity
culture
compared
culture.
As
2D,
model
provides
a
viable
vitro
for
studying
mechanisms
cancer.
represents
effective
new
NSCLC.
Язык: Английский