Abstract
Prostate
cancer
remains
a
lethal
disease
for
many
men.
Knowledge
of
genetic
contributions
to
this
condition
has
increasingly
been
used
in
its
management.
In
narrative
review,
we
summarize
various
alterations
and
syndromes
associated
with
prostate
cancer,
including
hereditary
breast
ovarian
syndrome,
Lynch
among
others.
Indications
germline
testing
are
reviewed,
as
well
incorporation
data
at
different
phases
management
such
screening
monitoring,
treatment
localized
metastatic
disease.
Pharmacological Research,
Год журнала:
2024,
Номер
205, С. 107234 - 107234
Опубликована: Май 28, 2024
After
the
initial
androgen
deprivation
therapy
(ADT),
part
of
prostate
cancer
may
continuously
deteriorate
into
castration-resistant
(CRPC).
The
majority
patients
suffer
from
localized
illness
at
primary
diagnosis
that
could
rapidly
assault
other
organs.
This
disease
stage
is
referred
as
metastatic
(mCRPC).
Surgery
and
radiation
are
still
treatment
CRPC,
but
have
some
adverse
effects
such
urinary
symptoms
sexual
dysfunction.
Hormonal
castration
interfering
receptor
(AR)
signaling
pathway
indispensable
for
most
advanced
patients,
first-
second-generation
novel
AR
inhibitors
effectively
cure
hormone
sensitive
(HSPC).
However,
resistance
to
these
chemical
agents
inevitable
many
experience
relapses.
inhibitor
mainly
involves
mutation,
splice
variant
formation
amplification,
which
indicates
important
role
in
CRPC.
Proteolysis-targeting
chimera
(PROTAC),
a
potent
technique
degrade
targeted
protein,
has
recently
undergone
extensive
development
biological
tool
therapeutic
drug.
potential
become
next
generation
antitumor
therapeutics
it
overcome
shortcomings
conventional
small
molecule
inhibitors.
In
this
review,
we
summarize
molecular
mechanisms
on
PROTACs
targeting
hoping
provide
insights
drug
clinical
medication.
Cancer Drug Resistance,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 19, 2025
Metastatic
castration-resistant
prostate
cancer
(mCRPC)
is
driven
by
a
complex
network
of
resistance
mechanisms
against
standard-of-care
therapies,
resulting
in
poor
long-term
outcomes.
This
review
offers
uniquely
comprehensive
and
integrative
perspective
on
these
pathways,
systematically
examining
both
androgen
receptor
(AR)-dependent
factors
(including
AR
overexpression,
point
mutations,
glucocorticoid
signaling,
splice
variants,
post-translational
modifications,
altered
coregulators,
intratumoral
hormone
biosynthesis)
AR-independent
pathways
(such
as
neuroendocrine
differentiation,
lineage
plasticity,
alternative
growth
factor
signaling).
We
also
highlight
influencing
immunotherapy,
chemotherapy,
radiopharmaceutical
therapy
targeted
therapy.
By
synthesizing
emerging
insights
across
domains,
this
not
only
clarifies
the
underlying
biology
mCRPC
but
identifies
key
leverage
points
for
more
effective
interventions.
Building
foundation,
we
propose
forward-looking
framework
overcoming
drug
resistance,
emphasizing
importance
biomarker-guided
patient
selection,
combination
strategies
that
simultaneously
target
multiple
mechanisms,
novel
therapies
under
investigation.
These
recommendations
are
intended
to
guide
future
clinical
trial
designs
research
priorities
move
beyond
incremental
improvements.
Ultimately,
synthesis
aims
serve
resource
clinicians
researchers
accelerate
development
durable,
precision-based
treatment
mCRPC.
Journal of Experimental & Clinical Cancer Research,
Год журнала:
2024,
Номер
43(1)
Опубликована: Июль 17, 2024
Continued
exploration
of
the
androgen
receptor
(AR)
is
crucial,
as
it
plays
pivotal
roles
in
diverse
diseases
such
prostate
cancer
(PCa),
serving
a
significant
therapeutic
focus.
Therefore,
Department
Urology
Dresden
hosted
an
international
meeting
for
scientists
and
clinical
oncologists
to
discuss
newest
advances
AR
research.
The
2nd
International
Androgen
Receptor
Symposium
was
held
Dresden,
Saxony,
Germany,
from
26-27.04.2024,
organised
by
Dr.
Holger
H.H.
Erb.
Following
format
first
meeting,
more
than
35
8
countries
attended
event
recent
developments,
research
challenges,
identification
venues
An
important
new
feature
involvement
PhD
students
young
investigators,
acknowledging
high
scientific
quality
their
work.
symposium
included
three
covers:
research,
basic
translational
novel
strategies
target
AR.
Moreover,
based
on
its
increasing
relevance,
PSMA
theranostic
mini-symposium
added
at
end
allow
audience
theranostic.
This
report
focuses
highlights
discussions
meeting.
Cancers,
Год журнала:
2024,
Номер
16(17), С. 3098 - 3098
Опубликована: Сен. 6, 2024
There
is
an
unmet
need
to
develop
new
treatments
for
metastatic
prostate
cancer.
With
the
development
of
targeted
radioligand
therapies,
bispecific
T
cell
engagers,
antibody-drug
conjugates
and
chimeric
antigen
receptor
(CAR
T)
tumor-associated
surface
antigens
have
emerged
as
therapeutic
targets
in
Ongoing
completed
clinical
trials
targeting
prostate-specific
membrane
(PSMA),
six
transmembrane
epithelial
1
(STEAP1),
kallikrein-related
peptidase
2
(KLK2),
stem
(PSCA),
delta-like
protein
3
(DLL3)
cancer
were
reviewed.
Strategies
sequential
or
combinational
therapy
discussed.
Expert Review of Anticancer Therapy,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 14, 2024
Prostate
cancer
continues
to
be
a
major
cause
of
morbidity
and
mortality
for
men
worldwide.
Enzalutamide,
second-generation
non-steroidal
antiandrogen
that
blocks
androgen
receptor
(AR)
transcriptional
activity,
is
treatment
biochemically-recurrent,
metastatic,
castration
sensitive,
resistant
tumors.
Unfortunately,
most
patients
ultimately
develop
resistance
enzalutamide,
making
long-term
with
this
agent
challenging.
International Journal of Newgen Research in Pharmacy & Healthcare,
Год журнала:
2024,
Номер
unknown, С. 142 - 148
Опубликована: Дек. 31, 2024
This
drug
delivery
system
is
designed
to
deliver
a
therapeutic
amount
of
medicine
the
right
place
in
body,
allowing
for
rapid
achievement
and
maintenance
desired
concentrations.
Gels
are
solids
or
semisolids
that
include
at
least
two
substances;
typically,
they
composed
dense
mass
surrounded
permeated
by
liquid.
A
number
chemical
components
present,
including
organic
acids,
flavonoids,
phenolic
acids.
Because
its
anti-inflammatory,
antibacterial,
antioxidant
characteristics,
Vigna
radiata
an
effective
acne
treatment.
Cosmetically
ubiquitous
Aloe
barbadensis
(Aloe
Vera)
has
long
been
known
efficacy
alleviating
skin
conditions
pigmentation,
acne,
burns,
more.
anti-inflammatory
wound-healing
it
useful
ingredient
prescription
treatments.
In
fact,
there
wide
spectrum
medicines
available
treatment
from
conventional
antibiotics
more
contemporary
methods
even
natural
cures.
Mixing
gel
with
ethanolic
extracts
Moringa
oleifera
resulted
improved
carbopol
base;
this
trio
herbal
may
help
reduce
acne.
The
antimicrobial
inquiry
did
not
find
any
signs
microbial
contamination
zone
inhibition.
vivo
irritation
examination
detect
lesions
such
defatting,
unpleasant
reactions,
local
systemic
alteration.
