Unraveling mechanism and enhancing selectivity of a RuII‐bis‐bipyridyl‐morphocumin complex with RAFT‐generated glycopolymer exploiting Warburg effect in cancer DOI
Arindam Mukherjee, Souryadip Roy, Soumya Paul

и другие.

Chemistry - A European Journal, Год журнала: 2024, Номер 31(8)

Опубликована: Ноя. 30, 2024

The Warburg effect, which generates increased demand of glucose in cancer cells is a relatively underexplored phenomenon existing commercial drugs to enhance uptake cells. Here, we present chemotherapeutic strategy employing Ru(II)-bis-bipyridyl-morphocumin complex (2) encapsulated self-assembling glucose-functionalized copolymer P(G-EMA-co-MMA) (where G=glucose; MMA=methyl methacrylate; EMA=ethyl methacrylate), designed exploit this effect for enhanced selectivity treatment. polymer, synthesized via reversible-addition fragmentation chain transfer (RAFT) polymerization, has number average molecular weight (Mn,NMR) 8000 g/mol. Complex 2, stable aqueous media, selectively releases cytotoxic, lysosome-targeting compound, morphocumin, the presence excess hydrogen peroxide (H₂O₂), reactive oxygen species (ROS) prevalent tumor microenvironments. Additionally, 2 promotes ROS accumulation, may further morphocumin release through synergistic domino effect. Comparative studies reveal that outperforms its curcumin Ru(II) (1) analog solution stability, organelle specificity, and cellular mechanisms. Both 1 exhibit phototherapeutic effects under low-intensity visible light, but their chemotoxicity significantly increases with incubation time dark, highlighting superior efficacy O,O-coordinating ternary polypyridyl complexes. induces apoptosis intrinsic pathway shows 9-fold increase pancreatic (MIA PaCa-2) over non-cancerous HEK293 when glucose-conjugated polymer (DP@2). Glucose deprivation culture medium enhances drug by an additional 5-fold. This work underscores potential polymers ROS-responsive complexes targeted therapy.

Язык: Английский

Balanced Duality: H2O2-Based Therapy in Cancer and Its Protective Effects on Non-Malignant Tissues DOI Open Access
Amira Zaher, Michael S. Petronek, Bryan G. Allen

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(16), С. 8885 - 8885

Опубликована: Авг. 15, 2024

Conventional cancer therapy strategies, although centered around killing tumor cells, often lead to severe side effects on surrounding normal tissues, thus compromising the chronic quality of life in survivors. Hydrogen peroxide (H

Язык: Английский

Процитировано

4
Effect of hydrogen peroxide pre-treatment on enhancing the cellular resistance of Tetrahymena pyriformis exposed to ionizing radiation DOI
Saloua Mabsor-Zgandaoui, Khawla Rachmoune, Aboubaker El Hessni

и другие.

Toxicological & Environmental Chemistry Reviews, Год журнала: 2025, Номер 107(2), С. 294 - 309

Опубликована: Фев. 7, 2025

Язык: Английский

Процитировано

0
Theoretical analysis, synthesis and biological activity against normal and cancer cells of a complex formed by a novel sugar cryptand and anticancer drug Mitomycin C DOI
Marta Hoelm, Stanisław Porwański, Paweł Jóźwiak

и другие.

Carbohydrate Research, Год журнала: 2025, Номер 551, С. 109425 - 109425

Опубликована: Фев. 13, 2025

Язык: Английский

Процитировано

0
H2O2‐Generating Advanced Nanomaterials for Cancer Treatment DOI Creative Commons
Kiyan Musaie, Samin Abbaszadeh,

Kik Marais

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 21, 2025

Abstract Tumor cells exploit abnormal redox homeostasis and the pro‐tumorigenic effect of reactive oxygen species (ROS) to enhance their survival progression. However, excessively high levels ROS can exceed oxidative stress threshold tumor cells, inducing cell death. This occur by selectively elevating concentration H 2 O in through both endogenous exogenous mechanisms. The generated serves as a precursor for toxic ROS, such • OH 1 , via chemodynamic photodynamic therapy, respectively, leading apoptosis, necrosis, ferroptosis. Strategies boost include direct delivery amplifying generation inhibiting antioxidant enzymes, leveraging glucose oxidase, employing photocatalytic therapy (PCT), utilizing metal peroxides. Among them, peroxides have displayed remarkable performance due excellent potential elevate within while simultaneously normalizing acidic hypoxic conditions microenvironment (TME). Moreover, these nanostructures sensitivity complementary treatments, like chemotherapy. review summarizes advanced perspectives design, synthesis, comparative analysis ‐generating nanoplatforms, emphasizing capacity treat various cancers.

Язык: Английский

Процитировано

0
Enhanced stability and activity of diaphorase enzyme immobilized on magnetic mesoporous silica DOI

Fahimeh Salari Goharrizi,

S. Yousef Ebrahimipour,

Masoud Torkzadeh Mahani

и другие.

Journal of Porous Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 29, 2025

Язык: Английский

Процитировано

0
Angiotensin II Exposure In Vitro Reduces High Salt-Induced Reactive Oxygen Species Production and Modulates Cell Adhesion Molecules’ Expression in Human Aortic Endothelial Cell Line DOI Creative Commons
Nikolina Kolobarić,

Nataša Kozina,

Zrinka Mihaljević

и другие.

Biomedicines, Год журнала: 2024, Номер 12(12), С. 2741 - 2741

Опубликована: Ноя. 29, 2024

Background/Objectives: Increased sodium chloride (NaCl) intake led to leukocyte activation and impaired vasodilatation via increased oxidative stress in human/animal models. Interestingly, subpressor doses of angiotensin II (AngII) restored endothelium-dependent vascular reactivity, which was a high-salt (HS) diet animal Therefore, the present study aimed assess effects AngII exposure following high salt loading on endothelial cells' (ECs') viability, activation, reactive oxygen species (ROS) production. Methods: The fifth passage human aortic cells (HAECs) cultured for 24, 48, 72 h with NaCl, namely, control (270 mOsmol/kg), HS320 (320 HS350 (350 mOsmol/kg). administered at half-time NaCl incubation (10-4-10-7 mol/L). Results: cell viability significantly reduced after 24 group all groups longer incubation. partly preserved HAECs shorter lower concentrations NaCl. Intracellular hydrogen peroxide (H2O2) peroxynitrite (ONOO-) compared control, while it decreased HS control. A significant decrease superoxide anion (O2.-) formation observed 10-5, 10-6, 10-7 mol/L both groups. There intracellular adhesion molecule 1 (ICAM-1) endoglin expression treatment 10-4 10-5 AngII. Conclusions: results demonstrated that ROS production modulated proliferation, states ECs.

Язык: Английский

Процитировано

1
A mechanistic insight on the biomimetic activity of surface engineered NH2-MIL-125 with α-Asarone for enhanced ROS production in lung cancer cells DOI Creative Commons
Sagnik Mukherjee, Anjali B. Thakkar,

Abhay Agola

и другие.

Results in Surfaces and Interfaces, Год журнала: 2024, Номер 17, С. 100274 - 100274

Опубликована: Авг. 27, 2024

The α-Asarone-loaded on NH2-MIL-125 (AS@AMIL) was demonstrated to be exceptional potential as a chemo dynamic therapeutic agent (CDT) for lung cancer cells (A549), showing superior efficiency compared α-Asarone well pristine NH2-MIL-125. loading of achieved through cation-π interactions between –NH3+ groups and aromatic ring α-Asarone. This interaction enriches the framework AS@AMIL with electrons enhancing basicity (O-atoms), which substantially accelerates decomposition endogenous H2O2 into reactive oxygen species (ROS) exhibit enhanced CDT activity. exhibited ∼1.36-fold increase in ROS production (CDT activity) study suggests that compounds amine functionalized MOFs (with groups) can enhance improved activity, such materials also promising catalysts CO2 adsorbents.

Язык: Английский

Процитировано

0
The progress and prospect of calcium peroxide nanoparticles in cancer therapy DOI Creative Commons
S Zhang, Chuanchuan He, Chunxia Zhang

и другие.

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 101, С. 106114 - 106114

Опубликована: Авг. 31, 2024

Язык: Английский

Процитировано

0
Designing Nano-Hemin for Ferroptosis-Mediated Cell Death via Enzymatic Hemin Digestion DOI
Abu Raihan Sarkar,

Nayana Mukherjee,

Ankan Kumar Sarkar

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 18, 2024

Hemin is a protoporphyrin complex of ferric ion which catalyzes H

Язык: Английский

Процитировано

0
Precision-engineered PROTACs minimize off-tissue effects in cancer therapy DOI Creative Commons

Jianghua Shi,

Luo Wang,

Xuanwei Zeng

и другие.

Frontiers in Molecular Biosciences, Год журнала: 2024, Номер 11

Опубликована: Ноя. 22, 2024

Proteolysis-targeting chimeras (PROTACs) offer a groundbreaking approach to selectively degrade disease-related proteins by utilizing the ubiquitin-proteasome system. While this strategy shows great potential in preclinical and clinical settings, off-tissue effects remain major challenge, leading toxicity healthy tissues. This review explores recent advancements aimed at improving PROTAC specificity, including tumor-specific ligand-directed PROTACs, pro-PROTACs activated tumor environments, E3 ligase overexpression strategies. Innovations such as PEGylation nanotechnology also play role optimizing efficacy. These developments hold promise for safer, more effective cancer therapies, though challenges translation.

Язык: Английский

Процитировано

0