Unraveling mechanism and enhancing selectivity of a RuII‐bis‐bipyridyl‐morphocumin complex with RAFT‐generated glycopolymer exploiting Warburg effect in cancer DOI
Arindam Mukherjee, Souryadip Roy, Soumya Paul

et al.

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: 31(8)

Published: Nov. 30, 2024

The Warburg effect, which generates increased demand of glucose in cancer cells is a relatively underexplored phenomenon existing commercial drugs to enhance uptake cells. Here, we present chemotherapeutic strategy employing Ru(II)-bis-bipyridyl-morphocumin complex (2) encapsulated self-assembling glucose-functionalized copolymer P(G-EMA-co-MMA) (where G=glucose; MMA=methyl methacrylate; EMA=ethyl methacrylate), designed exploit this effect for enhanced selectivity treatment. polymer, synthesized via reversible-addition fragmentation chain transfer (RAFT) polymerization, has number average molecular weight (Mn,NMR) 8000 g/mol. Complex 2, stable aqueous media, selectively releases cytotoxic, lysosome-targeting compound, morphocumin, the presence excess hydrogen peroxide (H₂O₂), reactive oxygen species (ROS) prevalent tumor microenvironments. Additionally, 2 promotes ROS accumulation, may further morphocumin release through synergistic domino effect. Comparative studies reveal that outperforms its curcumin Ru(II) (1) analog solution stability, organelle specificity, and cellular mechanisms. Both 1 exhibit phototherapeutic effects under low-intensity visible light, but their chemotoxicity significantly increases with incubation time dark, highlighting superior efficacy O,O-coordinating ternary polypyridyl complexes. induces apoptosis intrinsic pathway shows 9-fold increase pancreatic (MIA PaCa-2) over non-cancerous HEK293 when glucose-conjugated polymer (DP@2). Glucose deprivation culture medium enhances drug by an additional 5-fold. This work underscores potential polymers ROS-responsive complexes targeted therapy.

Language: Английский

H2O2‐Generating Advanced Nanomaterials for Cancer Treatment DOI Creative Commons
Kiyan Musaie, Samin Abbaszadeh,

Kik Marais

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

Abstract Tumor cells exploit abnormal redox homeostasis and the pro‐tumorigenic effect of reactive oxygen species (ROS) to enhance their survival progression. However, excessively high levels ROS can exceed oxidative stress threshold tumor cells, inducing cell death. This occur by selectively elevating concentration H 2 O in through both endogenous exogenous mechanisms. The generated serves as a precursor for toxic ROS, such • OH 1 , via chemodynamic photodynamic therapy, respectively, leading apoptosis, necrosis, ferroptosis. Strategies boost include direct delivery amplifying generation inhibiting antioxidant enzymes, leveraging glucose oxidase, employing photocatalytic therapy (PCT), utilizing metal peroxides. Among them, peroxides have displayed remarkable performance due excellent potential elevate within while simultaneously normalizing acidic hypoxic conditions microenvironment (TME). Moreover, these nanostructures sensitivity complementary treatments, like chemotherapy. review summarizes advanced perspectives design, synthesis, comparative analysis ‐generating nanoplatforms, emphasizing capacity treat various cancers.

Language: Английский

Citations

1
Balanced Duality: H2O2-Based Therapy in Cancer and Its Protective Effects on Non-Malignant Tissues DOI Open Access
Amira Zaher, Michael S. Petronek, Bryan G. Allen

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8885 - 8885

Published: Aug. 15, 2024

Conventional cancer therapy strategies, although centered around killing tumor cells, often lead to severe side effects on surrounding normal tissues, thus compromising the chronic quality of life in survivors. Hydrogen peroxide (H

Language: Английский

Citations

4
Effect of hydrogen peroxide pre-treatment on enhancing the cellular resistance of Tetrahymena pyriformis exposed to ionizing radiation DOI
Saloua Mabsor-Zgandaoui, Khawla Rachmoune, Aboubaker El Hessni

et al.

Toxicological & Environmental Chemistry Reviews, Journal Year: 2025, Volume and Issue: 107(2), P. 294 - 309

Published: Feb. 7, 2025

Language: Английский

Citations

0
Theoretical analysis, synthesis and biological activity against normal and cancer cells of a complex formed by a novel sugar cryptand and anticancer drug Mitomycin C DOI
Marta Hoelm, Stanisław Porwański, Paweł Jóźwiak

et al.

Carbohydrate Research, Journal Year: 2025, Volume and Issue: 551, P. 109425 - 109425

Published: Feb. 13, 2025

Language: Английский

Citations

0
Black Phosphorus Enabled Non Invasive Protein Detection with electromagnetic induction well Terahertz Biosensor Chips DOI Creative Commons
Xin Hu, Wenhao Xu, Xin Chen

et al.

Biomedical Optics Express, Journal Year: 2025, Volume and Issue: 16(4), P. 1546 - 1546

Published: March 14, 2025

Terahertz biosensors are employed to detect proteins in cancer cells facilitate early diagnosis and monitoring of treatments. By optimizing the design functionality black phosphorus-based sensors, it is possible enhance their sensitivity specificity for specific biomarkers, leading more accurate diagnostic outcomes. The application externally applied magnetic field 455 nm continuous-wave laser further augments cellular responses THz waves, with influences typically surpassing those light fields by 10%-80%. Our results examine photonic properties phosphorus, improve its interaction terahertz create prototypes that can selectively identify associated cells. Additionally, stability reproducibility these sensors have been greatly improved, boosting potential widespread use clinical environments.

Language: Английский

Citations

0
Enhanced stability and activity of diaphorase enzyme immobilized on magnetic mesoporous silica DOI

Fahimeh Salari Goharrizi,

S. Yousef Ebrahimipour,

Masoud Torkzadeh Mahani

et al.

Journal of Porous Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 29, 2025

Language: Английский

Citations

0
Stimuli-responsive smart nanomaterials for theranostics of urological cancers DOI

Yi Xu,

Madineh Moradialvand, Francesca Della Sala

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 539, P. 216745 - 216745

Published: May 1, 2025

Language: Английский

Citations

0
Angiotensin II Exposure In Vitro Reduces High Salt-Induced Reactive Oxygen Species Production and Modulates Cell Adhesion Molecules’ Expression in Human Aortic Endothelial Cell Line DOI Creative Commons
Nikolina Kolobarić,

Nataša Kozina,

Zrinka Mihaljević

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2741 - 2741

Published: Nov. 29, 2024

Background/Objectives: Increased sodium chloride (NaCl) intake led to leukocyte activation and impaired vasodilatation via increased oxidative stress in human/animal models. Interestingly, subpressor doses of angiotensin II (AngII) restored endothelium-dependent vascular reactivity, which was a high-salt (HS) diet animal Therefore, the present study aimed assess effects AngII exposure following high salt loading on endothelial cells' (ECs') viability, activation, reactive oxygen species (ROS) production. Methods: The fifth passage human aortic cells (HAECs) cultured for 24, 48, 72 h with NaCl, namely, control (270 mOsmol/kg), HS320 (320 HS350 (350 mOsmol/kg). administered at half-time NaCl incubation (10-4-10-7 mol/L). Results: cell viability significantly reduced after 24 group all groups longer incubation. partly preserved HAECs shorter lower concentrations NaCl. Intracellular hydrogen peroxide (H2O2) peroxynitrite (ONOO-) compared control, while it decreased HS control. A significant decrease superoxide anion (O2.-) formation observed 10-5, 10-6, 10-7 mol/L both groups. There intracellular adhesion molecule 1 (ICAM-1) endoglin expression treatment 10-4 10-5 AngII. Conclusions: results demonstrated that ROS production modulated proliferation, states ECs.

Language: Английский

Citations

1
A mechanistic insight on the biomimetic activity of surface engineered NH2-MIL-125 with α-Asarone for enhanced ROS production in lung cancer cells DOI Creative Commons
Sagnik Mukherjee, Anjali B. Thakkar,

Abhay Agola

et al.

Results in Surfaces and Interfaces, Journal Year: 2024, Volume and Issue: 17, P. 100274 - 100274

Published: Aug. 27, 2024

The α-Asarone-loaded on NH2-MIL-125 (AS@AMIL) was demonstrated to be exceptional potential as a chemo dynamic therapeutic agent (CDT) for lung cancer cells (A549), showing superior efficiency compared α-Asarone well pristine NH2-MIL-125. loading of achieved through cation-π interactions between –NH3+ groups and aromatic ring α-Asarone. This interaction enriches the framework AS@AMIL with electrons enhancing basicity (O-atoms), which substantially accelerates decomposition endogenous H2O2 into reactive oxygen species (ROS) exhibit enhanced CDT activity. exhibited ∼1.36-fold increase in ROS production (CDT activity) study suggests that compounds amine functionalized MOFs (with groups) can enhance improved activity, such materials also promising catalysts CO2 adsorbents.

Language: Английский

Citations

0
The progress and prospect of calcium peroxide nanoparticles in cancer therapy DOI Creative Commons
S Zhang, Chuanchuan He, Chunxia Zhang

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 101, P. 106114 - 106114

Published: Aug. 31, 2024

Language: Английский

Citations

0