Melatonin and the Skin: Current Progress and Perspectives for Human Health

Journal of Investigative Dermatology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Neuro–immuno–endocrinology of the skin: how environment regulates body homeostasis

Nature Reviews Endocrinology, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Language: Английский

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A Comprehensive Review on the Beneficial Roles of Vitamin D in Skin Health as a Bio-Functional Ingredient in Nutricosmetic, Cosmeceutical, and Cosmetic Applications

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 796 - 796

Published: Jan. 15, 2025

Vitamin D, also called the “sunshine” vitamin, has gained great attention recently due to observed high percentage of worldwide population being deficient in this essential bioactive vitamin. Primarily, vitamin D was known for its important role bone health. Nevertheless, recent research shown importance brain, heart, muscles, immune system, and skin health, distinct bio-functionality almost every tissue human body. Therefore, deficiency been highly correlated with multiple diseases, including dermatologically associated ones. Moreover, different methodologies are applied synthesize while main sources plasma levels factors that can cause adverse modifications multiple. Further upon exhibited notable against such as psoriasis, atopic dermatitis, vitiligo, acne, rosacea. In article, a critical review most relevant significant information regarding relationship between health is thoroughly conducted, emphasis given potential uses benefits several cosmetic applications. Current status, limitations, future perspectives potent extensively discussed.

Language: Английский

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Small-Molecule Tyrosinase Inhibitors for Treatment of Hyperpigmentation

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 788 - 788

Published: Feb. 8, 2025

Increasing attention is being focused on skin health currently, especially the excessive deposition of melanin in skin. Tyrosinase, rate-limiting enzyme biosynthesis, a crucial synthesis. However, existing tyrosinase inhibitors pose some degree toxicity to humans. Therefore, development more efficient and low-toxicity urgently needed. This review briefly depicts biosynthesis process crystal structure catalytic mechanism tyrosinase. The latest research progress regarding small-molecule also reviewed. Moreover, structure-function relationships are analyzed summarized. expected provide new scientific insights enable researchers explore safer potent inhibitors.

Language: Английский

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Temozolomide‐Promoted MGMT Transcription Contributes to Chemoresistance by Activating the ERK Signalling Pathway in Malignant Melanoma

Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(3)

Published: Jan. 28, 2025

Tumour cells possess a multitude of chemoresistance mechanisms, which could plausibly contribute to the ineffectiveness chemotherapy. O6-methylguanine-DNA methyltransferase (MGMT) is an important effector protein associated with Temozolomide (TMZ) resistance in various tumours. To some extent, expression level MGMT determines sensitivity TMZ, but mechanism its regulation has not been fully elucidated. Cultured malignant melanoma cell lines A375 and Sk-MEL28 were employed. A luciferase assay was used detect transcriptional activity promoter. Western blotting compare levels phosphorylated ERK1/2 (P-ERK1/2) after TMZ treatment. Immunofluorescent staining TMZ-induced DNA damage levels. The detected by MTT animal experiments. mRNA tested Quantitative real-time PCR (RT-qPCR). Flow cytometry measure apoptosis TMZ-treated cells. enhanced transcription through activating ERK pathway. inhibitors U0126 vemurafenib (vMF) inhibited induced MGMT. p-ERK1/2 closely related human MM tissues. vMF increased (MM) vitro vivo downregulating promoting MM. TMZ-promoted contributed instinctive signalling pathway melanoma. Our study indicates that use inhibitor combination potentially enhance effectiveness clinical treatment for

Language: Английский

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Molecular insights of vitamin D receptor SNPs and vitamin D analogs: a novel therapeutic avenue for vitiligo

Molecular Diversity, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Language: Английский

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PPAR-γ in Melanoma and Immune Cells: Insights into Disease Pathogenesis and Therapeutic Implications

Cells, Journal Year: 2025, Volume and Issue: 14(7), P. 534 - 534

Published: April 2, 2025

Changes in skin pigmentation, like hyperpigmentation or moles, can affect appearance and social life. Unlike locally containable malignant melanomas are aggressive spread rapidly, disproportionately affecting younger individuals with a high potential for metastasis. Research has shown that the peroxisome proliferator-activated receptor gamma (PPAR-γ) its ligands exhibit protective effects against melanoma. As transcription factor, PPAR-γ is crucial functions fatty acid storage glucose metabolism. Activation of promotes lipid uptake enhances sensitivity to insulin. In many cases, it also inhibits growth cancer cell lines, breast, gastric, lung, prostate cancer. melanoma, regulates proliferation, differentiation, apoptosis, survival. During tumorigenesis, controls metabolic changes immunogenicity stromal cells. agonists target hypoxia-induced angiogenesis tumor therapy, but their on tumors be suppressive promotional, depending environment. Published data show PPAR-γ-targeting agents effective specific groups patients, further studies needed understand lesser-known biological address existing safety concerns. This review provides summary current understanding involvement

Language: Английский

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Quercetin as a Potential Therapeutic Agent for Malignant Melanoma—A Review of Current Evidence and Future Directions

Medicina, Journal Year: 2025, Volume and Issue: 61(4), P. 656 - 656

Published: April 2, 2025

Neoplastic disorders, particularly malignant carcinomas, are complex systemic diseases characterized by unregulated cellular proliferation, the invasion of adjacent tissues, and potential metastasis to distant bodily sites. Among diverse spectrum cancer subtypes, melanoma is a highly aggressive form cutaneous originating in melanocytes, pigment-producing cells resident skin. This malignancy distinguished its rapid uncontrolled growth, as well propensity for vital organs, thereby posing significant challenges therapeutic intervention prognostication. Early detection crucial optimizing patient outcomes, diagnosis at an advanced stage often yields poor prognosis limited treatment options. Diagnostic modalities encompass comprehensive clinical evaluations dermatologists; radiological imaging techniques such ultrasonography, magnetic resonance (MRI), computed tomography (CT) scans; excisional biopsies accurate histopathological assessment. Malignant typically treated with surgery remove tumor, followed immunotherapy enhance immune response, targeted therapy tumors specific genetic mutations, chemotherapy stages, radiation manage metastasis, other adjunct therapies. review presents properties possible effects against quercetin found literature explores, based on observed physicochemical biological activity, development topical formulation application. Quercetin naturally occurring flavonoid compound abundant various plant-based food sources, including apples, onions, berries, citrus fruits, has exhibited promising antiproliferative, antioxidant, anticancer properties. Its distinctive biochemical structure enables effectively neutralize reactive oxygen species modulate key carcinogenic pathways, rendering it candidate managing tumors, melanoma.

Language: Английский

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Cell Death Modalities in Therapy of Melanoma

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3475 - 3475

Published: April 8, 2025

Melanoma, one of the most lethal cancers, demands urgent and effective treatment strategies. However, a successful therapeutic approach requires precise understanding mechanisms underlying melanoma initiation progression. This review provides an overview pathogenesis, identifies current pathogenic factors contributing to mortality, explores targeted therapy checkpoint inhibitor therapy. Furthermore, we examine classification corresponding therapies, along with advancements in various cell death for treatment. We also discuss status some drawbacks encountered during research stages such as resistance metastasis.

Language: Английский

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Grape constituents for protection against photodamage to skin

Photochemistry and Photobiology, Journal Year: 2025, Volume and Issue: unknown

Published: May 21, 2025

Abstract Cutaneous overexposure to ultraviolet radiation has a variety of deleterious effects. The extent which dietary factors are effective at moderating UV damage is significant issue. Grapes contain phytochemicals that protect against excessive damage. Components grapes, in particular resveratrol, proanthocyanidins, and cyanidin‐3‐glucoside, receiving considerable attention for their photoprotective actions because lack toxicity, abundance, low cost. Resveratrol proanthocyanidins potent antioxidants interfere with signal transduction immunosuppressive pathways activated by radiation, responsible its harmful Studies humans provide rationale further development as novel method photoprotection.

Language: Английский

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