Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs

Physiological Reviews, Год журнала: 2022, Номер 103(1), С. 31 - 276

Опубликована: Апрель 18, 2022

Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous regulator of a broad range physiological functions. H2S belongs to class molecules known gasotransmitters, which typically include nitric oxide (NO) and carbon monoxide (CO). Three enzymes are recognized sources in various cells tissues: cystathionine γ-lyase (CSE), β-synthase (CBS), 3-mercaptopyruvate sulfurtransferase (3-MST). The present article reviews regulation these well pathways their enzymatic nonenzymatic degradation elimination. multiple interactions with other labile (e.g., NO) reactive oxygen species also outlined. Next, biological targets signaling outlined, special reference or oxidative posttranscriptional modification (persulfidation sulfhydration) proteins effect on channels intracellular second messenger pathways, gene transcription translation, cellular bioenergetics metabolism. pharmacological molecular tools currently available study physiology reviewed, including utility limitations. In subsequent sections, role functions is membrane potential, endo- exocytosis, cell organelles (endoplasmic reticulum, Golgi, mitochondria), movement, cycle, differentiation, aspects regulated death. roles types organ systems overviewed, red blood cells, immune central peripheral nervous (with focus neuronal transmission, learning, memory formation), vascular function (including angiogenesis its specialized cerebrovascular, renal, pulmonary beds) senses, vision, hearing, taste smell, pain-sensing. Finally, (lung, heart, liver, kidney, urogenital organs, reproductive system, bone cartilage, skeletal muscle, endocrine organs) presented, aging) but extending some common pathophysiological conditions. From data, wide array significant all emerges characteristic bell-shaped biphasic effects highlighted. addition, key aspects, debated areas, future research translational areas identified.

Язык: Английский

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Desulfovibrio in the Gut: The Enemy within?

Microorganisms, Год журнала: 2023, Номер 11(7), С. 1772 - 1772

Опубликована: Июль 7, 2023

Desulfovibrio (DSV) are sulfate-reducing bacteria (SRB) that ubiquitously present in the environment and as resident commensal within human gastrointestinal tract. Though they minor residents of healthy gut, DSV opportunistic pathobionts may overgrow setting various intestinal extra-intestinal diseases. An increasing number studies have demonstrated a positive correlation between overgrowth (bloom) While relationship bloom disease pathology has not been clearly established, mounting evidence suggests causal role for these development. As most predominant genera SRB this review summarizes current knowledge regarding variety In study, we also discuss mechanisms by which contribute to pathology.

Язык: Английский

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Hydrogen Sulfide Biology and Its Role in Cancer

Molecules, Год журнала: 2022, Номер 27(11), С. 3389 - 3389

Опубликована: Май 25, 2022

Hydrogen sulfide (H2S) is an endogenous biologically active gas produced in mammalian tissues. It plays a very critical role many pathophysiological processes the body. can be endogenously through enzymes analogous to cysteine family, while exogenous source may involve inorganic salts. H2S has recently been well investigated with regard onset of various carcinogenic diseases such as lung, breast, ovaries, colon cancer, and neurodegenerative disorders. considered oncogenic gas, potential therapeutic target for treating diagnosing cancers, due its mediating development tumorigenesis. Here this review, in-detail up-to-date explanation different malignancies reported. The study summarizes synthesis H2S, roles, signaling routes, expressions, release malignancies. Considering importance biological molecule, we believe review esteemed journal will highlight scientific community.

Язык: Английский

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Implications of hydrogen sulfide in colorectal cancer: Mechanistic insights and diagnostic and therapeutic strategies

Redox Biology, Год журнала: 2023, Номер 59, С. 102601 - 102601

Опубликована: Янв. 7, 2023

Hydrogen sulfide (H2S) is an important signaling molecule in colorectal cancer (CRC). It produced the colon by catalytic synthesis of colonocytes' enzymatic systems and release intestinal microbes, oxidatively metabolized mitochondria. Both endogenous H2S colonic epithelial cells exogenous lumen contribute to onset progression CRC. The up-regulation synthetases thought be cause elevated levels CRC cells. Different diagnostic probes combination therapies, as well tumor treatment approaches through modulation, have been developed recent years become active area investigation for diagnosis In this review, we focus on specific mechanisms production oxidative metabolism function occurrence, progression, diagnosis, We also discuss present challenges provide insights into future research burgeoning field.

Язык: Английский

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Emerging Chemodynamic Nanotherapeutics for Cancer Treatment

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(22)

Опубликована: Май 16, 2024

Abstract Chemodynamic therapy (CDT) has emerged as a transformative paradigm in the realm of reactive oxygen species ‐mediated cancer therapies, exhibiting its potential sophisticated strategy for precise and effective tumor treatment. CDT primarily relies on metal ions hydrogen peroxide to initiate Fenton or Fenton‐like reactions, generating cytotoxic hydroxyl radicals. Its notable advantages treatment are demonstrated, including specificity, autonomy from external triggers, favorable side‐effect profile. Recent advancements nanomedicine devoted enhancing CDT, promising comprehensive optimization efficacy. This review systematically elucidates cutting‐edge achievements chemodynamic nanotherapeutics, exploring strategies enhanced improved microenvironment modulation, regulation energy metabolism. Moreover, detailed analysis diverse CDT‐mediated combination therapies is provided. Finally, concludes with discussion prospects intrinsic challenges application nanotherapeutics domain

Язык: Английский

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Emerging roles of cystathionine β-synthase in various forms of cancer

Redox Biology, Год журнала: 2022, Номер 53, С. 102331 - 102331

Опубликована: Май 10, 2022

The expression of the reverse transsulfuration enzyme cystathionine-β-synthase (CBS) is markedly increased in many forms cancer, including colorectal, ovarian, lung, breast and kidney, while other cancers (liver cancer glioma) it becomes downregulated. According to clinical database data high-CBS-expressor (e.g. colon or ovarian cancer), high CBS typically predicts lower survival, low-CBS-expressor liver low associated with survival. In high-CBS expressing tumor cells, CBS, its product hydrogen sulfide (H2S) serves as a bioenergetic, proliferative, cytoprotective stemness factor; also supports angiogenesis epithelial-to-mesenchymal transition microenvironment. current article reviews various tumor-cell-supporting roles CBS/H2S axis expressor overviews anticancer effects silencing pharmacological inhibition models vitro vivo; outlines potential approaches for biomarker identification, support future targeted therapies based on inhibition.

Язык: Английский

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The Hidden Role of Hydrogen Sulfide Metabolism in Cancer

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(12), С. 6562 - 6562

Опубликована: Июнь 18, 2021

Hydrogen Sulfide (H2S), an endogenously produced gasotransmitter, is involved in various important physiological and disease conditions, including vasodilation, stimulation of cellular bioenergetics, anti-inflammation, pro-angiogenesis. In cancer, aberrant up-regulation H2S-producing enzymes frequently observed different cancer types. The recognition that tumor-derived H2S plays roles during development reveals opportunities to target H2S-mediated signaling pathways therapy. this review, we will focus on the mechanism protein persulfidation detailed information about dysregulation metabolism We also provide update mechanisms progression summarize current options modulate production for

Язык: Английский

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Progress and perspective on hydrogen sulfide donors and their biomedical applications

Medicinal Research Reviews, Год журнала: 2022, Номер 42(5), С. 1930 - 1977

Опубликована: Июнь 3, 2022

Abstract Following the discovery of nitric oxide (NO) and carbon monoxide (CO), hydrogen sulfide (H 2 S) has been identified as third gasotransmitter in humans. Increasing evidence have shown that H S is preventive or therapeutic effects on diverse pathological complications. As a consequence, it great significance to develop suitable approaches S‐based therapeutics for biomedical applications. S‐releasing agents donors) play important roles exploring understanding physiological functions S. More importantly, accumulating studies validated theranostic potential donors extensive repertoires vitro vivo disease models. Thus, imperative summarize update literatures this field. In review, first, background its chemical biological aspects concisely introduced. Second, regarding compounds are categorized described, accordingly, their S‐donating mechanisms, applications, values also comprehensively delineated discussed. Necessary comparisons between related presented, drawbacks many typical analyzed revealed. Finally, several critical challenges encountered development multifunctional discussed, direction future well applications proposed. We expect review will reach audiences across multiple disciplines promote innovation biomedicine.

Язык: Английский

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Hydrogen Sulfide: An Emerging Regulator of Oxidative Stress and Cellular Homeostasis—A Comprehensive One-Year Review

Antioxidants, Год журнала: 2023, Номер 12(9), С. 1737 - 1737

Опубликована: Сен. 7, 2023

Hydrogen sulfide (H2S), traditionally recognized as a toxic gas, has emerged critical regulator in many biological processes, including oxidative stress and cellular homeostasis. This review presents an exhaustive overview of the current understanding H2S its multifaceted role mammalian functioning management. We delve into sources function H2S, mechanisms underlying homeostasis, intricate relationships between these processes. explore evidence from recent experimental clinical studies, unraveling biochemical molecular dictating H2S’s roles modulating responses maintaining The implications therapeutic potential conditions characterized by dysregulation disrupted homeostasis are discussed, highlighting emerging significance health disease. Finally, this underscores challenges, controversies, future directions field, emphasizing need for further research to harness agent diseases associated with homeostatic imbalance. Through review, we aim emphasize pivotal function, encouraging exploration burgeoning area research.

Язык: Английский

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H₂S-Reactivating Antitumor Immune Response after Microwave Thermal Therapy for Long-Term Tumor Suppression

ACS Nano, Год журнала: 2023, Номер 17(19), С. 19242 - 19253

Опубликована: Окт. 2, 2023

Microwave thermal therapy (MWTT) is one of the most potent ablative treatments known, with advantages like deep penetration, minimal invasion, repeatable operation, and low interference from bone gas. However, microwave (MW) not selective against tumors, residual tumors after incomplete ablation will generate immunosuppression, ultimately making prone to recurrence metastasis. Herein, a nano-immunomodulator (Bi-MOF-l-Cys@PEG@HA, BMCPH) proposed reverse immunosuppression reactivate antitumor immune effect through responsively releasing H2S in tumor cells for improving MWTT. Under MW irradiation, BMCPH mediate MWTT ablate release l-cysteine (l-Cys) react highly expressed cystathionine β-synthase H2S. The generated can inhibit accumulation myeloid-derived suppressor (MDSCs) promote expression cytotoxic T lymphocytes (CTLs). Moreover, Bi-MOF also scavenge reactive oxygen species (ROS), major means MDSCs-mediated further weaken immunosuppressive effect. Simultaneously, surface-covered HA gather CTLs around enhance response. This nano gas immunomodulator provides an idea sensitive tunable unstable molecules at sites. strategy response introduces direction reduce risk metastasis ablation.

Язык: Английский

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