Precision Nanomedicine,
Год журнала:
2023,
Номер
6(2)
Опубликована: Июль 7, 2023
In
this
study,
we
review
the
synthesis
of
copper
nanoparticles
(CuNPs)
and
their
prospective
uses
as
antioxidants,
antimicrobials,
anticancer
agents
in
pharmaceutical
sector.
Copper
could
be
created
through
a
variety
methods,
including
chemical
reduction,
green
synthesis,
physical
electrochemical
deposition,
microemulsion
method.
These
methods
make
it
possible
to
precisely
create
with
necessary
shapes,
sizes,
surface
properties,
which
turn
affect
how
well
they
perform
biologically.
CuNPs
have
strong
antioxidant
properties
because
can
scavenge
reactive
oxygen
species
(ROS)
prevent
oxidative
damage.
addition
show
antibacterial
activity
against
number
microbes,
bacteria,
fungi,
viruses.
The
potential
an
agent
has
also
been
extensively
investigated.
toxic
effects
on
cancer
cell
lines
by
inducing
apoptosis,
inhibiting
proliferation,
preventing
tumour
angiogenesis.
Because
specific
toxicity
towards
cells
while
protecting
normal
cells,
provide
fascinating
for
tailored
therapy
overcome
multidrug
resistance.
studied
relation
usage
medications.
They
may
utilised
improve
drug
delivery
systems,
wound
healing,
diagnostic
imaging,
immunotherapy,
anti-inflammatory
effects.
used
stability,
bioavailability,
controlled
release.
More
research
is
needed
ensure
safety,
enhance
processes,
explore
full
therapeutic
situations
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
13(4)
Опубликована: Сен. 24, 2023
Abstract
The
colon
tumor
microenvironment
has
a
high
concentration
of
H
2
S
and
glutathione,
which
is
highly
immunosuppressive
adverse
to
multiple
therapeutic
methodologies
such
as
ferroptosis.
Here,
an
engineered
microbial
nanohybrid
based
on
Escherichia
coli
(
E.
)
Cu
O
nanoparticles
specific
therapy
immunosuppression
reversion
reported.
as‐prepared
@Cu
hybrid
can
accumulate
in
sites
upon
intravenous
injection,
convert
x
by
consuming
the
endogenous
S,
exhibits
strong
photothermal
conversion
at
near‐infrared
II
(NIR
II)
biological
window.
Furthermore,
able
induce
cellular
ferroptosis
cuproptosis
through
inactivation
glutathione
peroxidase
4
aggregation
dihydrolipoamide
S‐acetyltransferase,
respectively.
Photothermal‐enhanced
ferroptosis/cuproptosis
achieved
reverses
tumors
triggering
dendritic
cell
maturation
(about
30%)
T
activation
50%
CD8
+
cells).
Concerted
with
immune
checkpoint
blockade,
inhibit
growth
abscopal
NIR
illumination.
Overall,
designed
achieve
tumor‐specific
photothermal‐enhanced
reversion,
showing
promise
precise
future
clinical
translation.
Antioxidants,
Год журнала:
2023,
Номер
12(9), С. 1737 - 1737
Опубликована: Сен. 7, 2023
Hydrogen
sulfide
(H2S),
traditionally
recognized
as
a
toxic
gas,
has
emerged
critical
regulator
in
many
biological
processes,
including
oxidative
stress
and
cellular
homeostasis.
This
review
presents
an
exhaustive
overview
of
the
current
understanding
H2S
its
multifaceted
role
mammalian
functioning
management.
We
delve
into
sources
function
H2S,
mechanisms
underlying
homeostasis,
intricate
relationships
between
these
processes.
explore
evidence
from
recent
experimental
clinical
studies,
unraveling
biochemical
molecular
dictating
H2S’s
roles
modulating
responses
maintaining
The
implications
therapeutic
potential
conditions
characterized
by
dysregulation
disrupted
homeostasis
are
discussed,
highlighting
emerging
significance
health
disease.
Finally,
this
underscores
challenges,
controversies,
future
directions
field,
emphasizing
need
for
further
research
to
harness
agent
diseases
associated
with
homeostatic
imbalance.
Through
review,
we
aim
emphasize
pivotal
function,
encouraging
exploration
burgeoning
area
research.
Acta Physiologica,
Год журнала:
2025,
Номер
241(2)
Опубликована: Янв. 13, 2025
Ca2+
and
Mg2+
are
essential
nutrients,
deficiency
can
cause
serious
health
problems.
Thus,
lack
of
lead
to
osteoporosis,
with
incidence
rising
both
in
absolute
age-specific
terms,
while
is
associated
type
II
diabetes.
Prevention
via
vitamin
D
or
estrogen
controversial,
the
bioavailability
from
supplements
significantly
lower
than
that
milk
products.
Problems
likely
increase
as
populations
age
number
people
on
vegan
diets
surges.
Developing
new
therapeutic
strategies
requires
a
better
understanding
molecular
mechanisms
involved
absorption
by
intestinal
epithelia.
The
vitamin-D
dependent,
active
pathway
for
uptake
upper
small
intestine
involving
TRPV6
highly
efficient
but
only
accounts
about
20%
total
uptake.
Instead,
most
thought
occur
passive
paracellular
diffusion
across
ileum,
although
sufficiently
high
luminal
concentrations
difficult
achieve..
Interestingly,
colon
caecum
also
have
considerable
capacity
Mg2+,
which
unclear.
Intriguingly,
stimulating
fermentation
prebiotics
enhances
colonic
absorption,
rise
~10%
~30%
total.
Notably,
releases
protons,
inhibits
channels
selective
(TRPV6
TRPM6/TRPM7).
Conversely,
non-selective
cation
channel
TRPV3
stimulated
intracellular
acidification
numerous
herbal
compounds.
Spicy,
fiber-rich
food,
traditionally
consumed
many
cultures,
might
enhance
this
pathway.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 27, 2025
Abstract
This
article
provides
an
overview
of
the
advancements
in
application
fecal
microbiota
transplantation
(FMT)
treating
diseases
related
to
intestinal
dysbiosis.
FMT
involves
transfer
healthy
donor
into
patient's
body,
aiming
restore
balance
and
thereby
treat
a
variety
such
as
recurrent
Clostridioides
difficile
infection
(rCDI),
inflammatory
bowel
disease
(IBD),
constipation,
short
syndrome
(SBS),
irritable
(IBS).
While
has
shown
high
efficacy
treatment
rCDI,
further
research
is
needed
for
its
other
chronic
conditions.
elaborates
on
mechanisms
dysbiosis,
well
discusses
key
factors
influencing
effectiveness
FMT,
including
selection,
recipient
characteristics,
protocols,
methods
assessing
microbiota.
Additionally,
it
emphasizes
successful
FMT.
Future
should
focus
optimizing
process
ensure
long‐term
safety
explore
potential
broader
range
medical
Molecules and Cells,
Год журнала:
2024,
Номер
47(8), С. 100095 - 100095
Опубликована: Июль 18, 2024
Metabolic
networks
are
fundamental
to
cellular
processes,
driving
energy
production,
biosynthesis,
redox
regulation,
and
signaling.
Recent
advancements
in
metabolic
research
tools
have
provided
unprecedented
insights
into
metabolism.
Among
these
tools,
the
extracellular
flux
analyzer
stands
out
for
its
real-time
measurement
of
key
parameters:
glycolysis,
mitochondrial
respiration,
fatty
acid
oxidation,
leading
widespread
use.
This
review
provides
a
comprehensive
summary
basic
principles
workflow
assay
(the
Seahorse
assay)
diverse
applications.
We
highlight
assay's
versatility
across
various
biological
models,
including
cancer
cells,
immunocytes,
Caenorhabditis
elegans,
tissues,
isolated
mitochondria,
three-dimensional
structures
such
as
organoids,
summarize
considerations
using
models.
Additionally,
we
discuss
limitations
propose
future
directions
development.
aims
enhance
understanding
significance
studies.
Journal of Science Advanced Materials and Devices,
Год журнала:
2024,
Номер
9(3), С. 100770 - 100770
Опубликована: Июль 23, 2024
Due
to
the
non-specific
distribution
of
drugs
in
body
and
low
concentration
at
tumor
site
traditional
chemotherapy,
there
are
challenges
associated
with
significant
side
effects
resistance.
Therefore,
a
drug
delivery
system
(DDS)
urgently
needs
be
developed
that
can
precisely
target
tumors.
Metal-organic
frameworks
(MOFs)
possess
advantageous
characteristics
derived
from
organic
inorganic
materials,
including
small
particle
size,
large
specific
surface
area,
high
loading
capacity,
adjustable
structure
pore
as
well
ease
modification.
Consequently,
MOFs
offer
unique
advantages
for
designing
active
targeting,
passive
stimulus-responsive
targeting
strategies
have
become
hot
topic
current
research
on
tumor-targeted
systems.
This
review
will
elaborate
application
systems
perspective
different
strategies.
We
hope
this
paper
provide
assistance
therapy.
Journal of Medicinal Chemistry,
Год журнала:
2024,
Номер
67(9), С. 7431 - 7442
Опубликована: Апрель 26, 2024
Since
hydrogen
sulfide
(H2S)
is
an
important
endogenous
gaseous
mediator,
therapeutic
manipulation
of
H2S
promising
for
anticancer
treatment.
In
this
work,
we
develop
a
novel
theranostic
nanoplatform
with
H2S-specific
and
photocontrolled
synergistic
activation
imaging-guided
depletion
downregulation
along
promoted
photothermal
therapy.
Such
fabricated
by
integration
H2S-responsive
molecule
probe
that
can
generate
cystathionine-β-synthase
(CBS)
inhibitor
AOAA
transducer
into
NIR-light-responsive
container.
Our
turn
on
NIR
fluorescence
specifically
in
H2S-rich
cancers,
guiding
further
laser
irradiation.
Furthermore,
prominent
conversion
photoenergy
heat
guarantees
special
container
melting
controllable
release
H2S-level
downregulation.
This
smart
regulation
the
level
amplifies
PTT
effect,
successfully
suppressing
colorectal
tumor
living
mice
under
imaging
guidance.
Thus,
believe
may
provide
powerful
tool
toward
H2S-concerned
cancer
treatment
optimized
diagnostic
effect.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
161, С. 114506 - 114506
Опубликована: Март 10, 2023
As
an
endogenous
gas
signalling
molecule,
hydrogen
sulfide
(H2S)
is
frequently
present
in
a
variety
of
mammals
and
plays
significant
role
the
cardiovascular
nervous
systems.
Reactive
oxygen
species
(ROS)
are
produced
large
quantities
as
result
cerebral
ischaemia-reperfusion,
which
very
serious
class
cerebrovascular
diseases.
ROS
cause
oxidative
stress
induce
specific
gene
expression
that
results
apoptosis.
H2S
reduces
ischaemia-reperfusion-induced
secondary
injury
via
anti-oxidative
injury,
suppression
inflammatory
response,
inhibition
apoptosis,
attenuation
endothelial
cell
modulation
autophagy,
antagonism
P2X7
receptors,
it
important
biological
other
ischaemic
events.
Despite
many
limitations
therapy
delivery
strategy
difficulty
controlling
ideal
concentration,
relevant
experimental
evidence
demonstrating
excellent
neuroprotective
ischaemia-reperfusion
(CIRI).
This
paper
examines
synthesis
metabolism
molecule
brain
well
molecular
mechanisms
donors
possibly
unknown
functions.
With
active
development
this
field,
expected
review
will
assist
researchers
their
search
for
potential
value
provide
new
ideas
preclinical
trials
exogenous
H2S.
