Ageing Research Reviews, Год журнала: 2024, Номер unknown, С. 102515 - 102515
Опубликована: Сен. 1, 2024
Язык: Английский
Clinical Microbiology Reviews, Год журнала: 2022, Номер 35(1)
Опубликована: Янв. 5, 2022
The human body is full of an extensive number commensal microbes, consisting bacteria, viruses, and fungi, collectively termed the microbiome. initial acquisition microbiota occurs from both external maternal environments, vast majority them colonize gastrointestinal tract (GIT). These microbial communities play a central role in maturation development immune system, nervous GIT system are also responsible for essential metabolic pathways. Various factors, including host genetic predisposition, environmental lifestyle, diet, antibiotic or nonantibiotic drug use, etc., affect composition gut microbiota. Recent publications have highlighted that imbalance microflora, known as dysbiosis, associated with onset progression neurological disorders. Moreover, characterization microbiome-host cross talk pathways provides insight into novel therapeutic strategies. Novel preclinical clinical research on interventions related to microbiome treating conditions, autism spectrum disorders, Parkinson's disease, schizophrenia, multiple sclerosis, Alzheimer's epilepsy, stroke, hold significant promise. This review aims present comprehensive overview potential involvement pathogenesis particular emphasis microbe-based therapies and/or diagnostic biomarkers. discusses health benefits administration probiotics, prebiotics, postbiotics, synbiotics fecal transplantation
Язык: Английский
Процитировано
326
EBioMedicine, Год журнала: 2022, Номер 77, С. 103908 - 103908
Опубликована: Март 1, 2022
The recent revelation that the gut microbiome, home to approximately 100 trillion microorganisms, is implicated in development of both health and disease has spurred an exponential increase interdisciplinary research involving microbiology. In all this hype, there a need better understand contextualize emerging evidence for role microbiota neurodegenerative neurodevelopmental diseases, including central nervous system (CNS) malignancies. review, we aim unravel complex interactions microbiota-gut-brain-axis pave understanding microbiota-mediated pathogenesis, avenues noninvasive prognosis, therapeutic possibilities leveraging modulations. We further provide insights ongoing transition from bench bedside discuss limitations current approaches. Ultimately, urge continued synergistic models with considerable consideration many gut-resident bacteria will enable significant progress treatment neurological diseases.
Язык: Английский
Процитировано
215
Molecular Neurodegeneration, Год журнала: 2022, Номер 17(1)
Опубликована: Март 5, 2022
The implication of gut microbiota in the control brain functions health and disease is a novel, currently emerging concept. Accumulating data suggest that exert its action at least part by modulating neuroinflammation. Given link between neuroinflammatory changes neuronal activity, it plausible may affect indirectly impacting microglia, key player Indeed, increasing evidence suggests interplay microglia synaptic dysfunction involve microbiota, among other factors. In addition to these indirect microglia-dependent actions on has been recently recognized could also activity directly stimulation vagus nerve.
Язык: Английский
Процитировано
207
Brain Behavior and Immunity, Год журнала: 2022, Номер 106, С. 76 - 88
Опубликована: Авг. 10, 2022
Gut microbiota alterations might affect the development of Alzheimer's disease (AD) through microbiota-derived metabolites. For example, Indoles via tryptophan metabolism prevented Aβ accumulation and Tau hyperphosphorylation, restored synaptic plasticity, then promoted cognitive behavioral ability APP/PS1 mice. The imbalanced compositions Indoles-producing bacteria with deficiency were found in male mice, but molecular mechanisms remained unclear. Our current study revealed that (including indole, indole-3-acetic acid indole-3-propionic acid) upregulated production aryl hydrocarbon receptor (AhR), inhibited activation NF-κB signal pathway as well formation NLRP3 inflammasome, reduced release inflammatory cytokines, including TNF-α, IL-6, IL-1β IL-18, alleviating response These findings demonstrated roles activating AhR to regulate neuroinflammation AD gut Indoles, which implied a novel way for treatment.
Язык: Английский
Процитировано
106
Molecular Psychiatry, Год журнала: 2022, Номер 27(4), С. 1908 - 1919
Опубликована: Март 2, 2022
Язык: Английский
Процитировано
82
Neuroscience & Biobehavioral Reviews, Год журнала: 2023, Номер 150, С. 105195 - 105195
Опубликована: Апрель 24, 2023
Язык: Английский
Процитировано
53
Gut Microbes, Год журнала: 2024, Номер 16(1)
Опубликована: Янв. 23, 2024
The gut microbiota (GM) and its metabolites affect the host nervous system are involved in pathogeneses of various neurological diseases. However, specific GM alterations under pathogenetic pressure their contributions to "microbiota – metabolite brain axis" Alzheimer's disease (AD) remain unclear. Here, we investigated fecal, serum, cortical metabolomes APP/PS1 wild-type (WT) mice, revealing distinct hub bacteria AD mice within scale-free networks shared by both groups. Moreover, identified diverse peripheral central metabolic landscapes between WT that featured bile acids (e.g. deoxycholic isodeoxycholic acid) unsaturated fatty 11Z-eicosenoic palmitoleic acid). Machine-learning models revealed relationships differential/hub these signatures from periphery brain. Notably, AD-enriched Dubosiella affected occurrence via acid vice versa. Considering transgenic background propose enrichment impedes progression synthesis acid, which has protective properties against inflammation disorders. We another association involving fecal acid-mediated interactions Erysipelatoclostridium occurrence, was corroborated correlation deoxycholate levels cognitive scores humans. Overall, this study elucidated network alterations, landscapes, mediatory roles thus critical pathogenesis communications pressure.
Язык: Английский
Процитировано
24
Gut Microbes, Год журнала: 2024, Номер 16(1)
Опубликована: Июль 15, 2024
The gut microbial ecosystem communicates bidirectionally with the brain in what is known as gut-microbiome-brain axis. Bidirectional signaling occurs through several pathways including via vagus nerve, circulation of metabolites, and immune activation. Alterations microbiota are implicated Alzheimer's disease (AD), a progressive neurodegenerative disease. Perturbations communities may affect within axis altered production metabolites ɣ-aminobutyric acid (GABA), primary inhibitory mammalian neurotransmitter. GABA has been shown to act on integrity modulation mucins tight junction proteins be involved nerve signal inhibition. GABAergic pathway dysregulated AD, responsive interventions. Gut recent interest neurological disorders, AD. Bacteroides Lactic Acid Bacteria (LAB), Lactobacillus, predominant producers GABA. This review highlights how temporal alterations associated AD pathway, intestinal barrier integrity, AD-associated inflammation.
Язык: Английский
Процитировано
20
Gut Microbes, Год журнала: 2024, Номер 16(1)
Опубликована: Янв. 18, 2024
Trillions of microbes live symbiotically in the host, specifically mucosal tissues such as gut. Recent advances metagenomics and metabolomics have revealed that gut microbiota plays a critical role regulation host immunity metabolism, communicating through bidirectional interactions microbiota-gut-brain axis (MGBA). The regulates both systemic contributes to neurodevelopment behaviors host. With aging, composition changes, emerging studies linked these shifts microbial populations age-related neurological diseases (NDs). Preclinical demonstrated microbiota-targeted therapies can improve behavioral outcomes by modulating microbial, metabolomic, immunological profiles. In this review, we discuss pathways brain-to-gut or gut-to-brain signaling summarize metabolites across lifespan disease. We highlight recent investigating 1) changes with aging; 2) how aging maternal microbiome affect offspring health; 3) contribution chronic (e.g., Parkinson's disease, Alzheimer's disease cerebral amyloidosis), acute brain injury, including ischemic stroke traumatic injury.
Язык: Английский
Процитировано
17
Nutrients, Год журнала: 2022, Номер 14(10), С. 2161 - 2161
Опубликована: Май 23, 2022
Anthocyanins are mainly purple-coloured phenolic compounds of plant origin that as secondary metabolites important in survival. Understanding their health benefits humans requires sourcing these unstable sufficient quantities at a reasonable cost, which has led to improved methods extraction. Dark-coloured fruits, cereals and vegetables current sources compounds. The range potential sustainable is much larger includes non-commercialised native plants from around the world agri-waste containing anthocyanins. In last 5 years, there have been significant advances developing therapeutic anthocyanins chronic human diseases. exert beneficial effects through improvements gut microbiota, oxidative stress inflammation, modulation neuropeptides such insulin-like growth factor-1. Their include reduced cognitive decline; protection organs liver, well cardiovascular system, gastrointestinal tract kidneys; bone obesity; regulation glucose lipid metabolism. This review summarises some mechanisms treatment
Язык: Английский
Процитировано
50