The gut microbiome and Alzheimer’s disease: Complex and bidirectional interactions

Neuroscience & Biobehavioral Reviews, Год журнала: 2022, Номер 141, С. 104814 - 104814

Опубликована: Авг. 4, 2022

Язык: Английский

---

Water-extracted Lonicera japonica polysaccharide attenuates allergic rhinitis by regulating NLRP3-IL-17 signaling axis

Carbohydrate Polymers, Год журнала: 2022, Номер 297, С. 120053 - 120053

Опубликована: Сен. 3, 2022

Язык: Английский

---

Myelin in Alzheimer’s disease: culprit or bystander?

Acta Neuropathologica Communications, Год журнала: 2023, Номер 11(1)

Опубликована: Март 31, 2023

Alzheimer's disease (AD) is a neurodegenerative disorder with neuronal and synaptic losses due to the accumulation of toxic amyloid β (Αβ) peptide oligomers, plaques, tangles containing tau (tubulin-associated unit) protein. While familial AD caused by specific mutations, sporadic more common appears result from complex chronic brain neuroinflammation mitochondriopathies, inducing free radicals' accumulation. In aged brain, mutations in DNA several unfolded proteins participate amyloidosis response effect on myelin sheath axons, leading cognitive deficits dementia. Αβ peptides are most frequent form oligomers. Accumulations misfolded during years alters different metabolic mechanisms, induce inflammatory immune responses consequences cells. Myelin composition architecture may appear be an early target for activity Aβ others hydrophobic proteins. this work, we describe possible role alterations genesis onset symptomatology. We propose that some pathophysiological clinical forms arise structural disorders processes myelination/demyelination regions where non-functional important. these forms, primacy deleterious would matter questioning initiating neuropathology primarily fact dysmyelination.

Язык: Английский

---

Probiotics and the microbiota-gut-brain axis in neurodegeneration: Beneficial effects and mechanistic insights

Life Sciences, Год журнала: 2024, Номер 350, С. 122748 - 122748

Опубликована: Июнь 5, 2024

Язык: Английский

---

Gut microbiota in health and disease: advances and future prospects

MedComm, Год журнала: 2024, Номер 5(12)

Опубликована: Ноя. 20, 2024

Abstract The gut microbiota plays a critical role in maintaining human health, influencing wide range of physiological processes, including immune regulation, metabolism, and neurological function. Recent studies have shown that imbalances composition can contribute to the onset progression various diseases, such as metabolic disorders (e.g., obesity diabetes) neurodegenerative conditions Alzheimer's Parkinson's). These are often accompanied by chronic inflammation dysregulated responses, which closely linked specific forms cell death, pyroptosis ferroptosis. Pathogenic bacteria trigger these death pathways through toxin release, while probiotics been found mitigate effects modulating responses. Despite insights, precise mechanisms influences diseases remain insufficiently understood. This review consolidates recent findings on impact immune‐mediated inflammation‐associated conditions. It also identifies gaps current research explores potential advanced technologies, organ‐on‐chip models microbiome–gut–organ axis, for deepening our understanding. Emerging tools, single‐bacterium omics spatial metabolomics, discussed their promise elucidating microbiota's disease development.

Язык: Английский

---

Fecal Microbiota Transplantation Improves Cognitive Function of a Mouse Model of Alzheimer's Disease

CNS Neuroscience & Therapeutics, Год журнала: 2025, Номер 31(2)

Опубликована: Фев. 1, 2025

ABSTRACT Background A growing body of evidence suggests a link between the gut microbiota and Alzheimer's disease (AD), although underlying mechanisms remain elusive. This study aimed to investigate impact fecal transplantation (FMT) on cognitive function in mouse model AD. Methods Four‐month‐old 5 × FAD (familial disease) mice underwent antibiotic treatment deplete their native microbiota. Subsequently, they received FMT either weekly or every other day. After 8 weeks, β‐amyloid (Aβ) load were assessed through behavioral testing pathological analysis, respectively. The composition was analyzed using 16S rRNA sequencing. Results Initial failed alleviate memory deficits reduce brain Aβ pathology mice. In contrast, administered day effectively restored dysbiosis decreased lipopolysaccharide levels colon hippocampus. Mechanistically, reduced expression amyloid β precursor protein, β‐site APP cleaving enzyme 1, presenilin‐1, potentially by inhibiting Toll‐like receptor 4/inhibitor kappa B kinase β/nuclear factor kappa‐B signaling pathway. However, benefits diminished over time. Conclusion These findings demonstrate dose‐ time‐dependent efficacy mitigating AD‐like pathology, underscoring potential targeting for AD treatment.

Язык: Английский

---

Microbiome Gut-Brain-Axis: Impact on Brain Development and Mental Health

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 15, 2025

Abstract The current discovery that the gut microbiome, which contains roughly 100 trillion microbes, affects health and disease has catalyzed a boom in multidisciplinary research efforts focused on understanding this relationship. Also, it is commonly demonstrated CNS are closely related bidirectional pathway. A balanced microbiome essential for regular brain activities emotional responses. On other hand, regulates majority of GI physiology. Any disruption pathway led to progression problems both directions, neurological gastrointestinal diseases. In review, we hope shed light complicated connections microbiome-gut-brain axis critical roles early development order get deeper knowledge microbiome-mediated pathological conditions management options through rebalancing microbiome.

Язык: Английский

---

Lactobacillus plantarum PS128 prevents cognitive dysfunction in Alzheimer’s disease mice by modulating propionic acid levels, glycogen synthase kinase 3 beta activity, and gliosis

BMC Complementary Medicine and Therapies, Год журнала: 2021, Номер 21(1)

Опубликована: Окт. 9, 2021

According to recent evidence, psychobiotics exert beneficial effects on central nervous system-related diseases, such as mental disorders. Lactobacillus plantarum PS128 (PS128), a novel psychobiotic strain, improves motor function, depression, and anxiety behaviors. However, the mechanisms of in Alzheimer's disease (AD) remain be explored.The goal current study was evaluate further elucidate its mechanism AD mice.PS128 (1010 colony-forming unit (CFU)/ml) administered via oral gavage (o.g.) 6-month-old male wild-type B6 3 × Tg-AD mice (harboring PS1M146V, APPswe TauP30IL transgenes) that received an intracerebroventricular injection streptozotocin (icv-STZ, mg/kg) or vehicle (saline) for 33 days. After serial behavioral tests, fecal short-chain fatty acid levels AD-related pathology were assessed these mice.Our findings show accelerated cognitive dysfunction associated with increasing glycogen synthase kinase beta (GSK3β) activity, tau protein phosphorylation at T231 site (pT231), amyloid-β (Aβ) deposition, precursor (AβPP), β-site AβPP-cleaving enzyme (BACE1), gliosis, propionic (PPA) cognition-related neuronal loss decreasing postsynaptic density 95 (PSD95) mice. supplementation effectively prevented damage induced by mice.Based experimental results, accelerates progression mice, primarily which mediated pathways. prevents regulating levels, gliosis Therefore, we suggest is potential strategy prevent and/or delay AD.

Язык: Английский

---

Porphyromonas gingivalis-Induced Cognitive Impairment Is Associated With Gut Dysbiosis, Neuroinflammation, and Glymphatic Dysfunction

Frontiers in Cellular and Infection Microbiology, Год журнала: 2021, Номер 11

Опубликована: Дек. 1, 2021

Background Periodontal pathogen and gut microbiota are closely associated with the pathogenesis of Alzheimer’s disease (AD). Porphyromonas gingivalis (Pg), keystone periodontal pathogen, can induce cognitive impairment. The has a connection communication brain, which is an important aspect gut–brain axis (GBA). In present study, we investigate whether Pg induces impairment through disturbing GBA. Methods this was orally administered to mice, three times week for 1 month. effects administration on brain were evaluated behaviors, microbiota, immune cells, glymphatic pathway clearance, neuroinflammation. Results induced dysbiosis microbiota. α-diversity parameters did not show significant change after administration. β-diversity demonstrated that compositions different between Pg-administered control groups. At species level, group displayed lower abundance Parabacteroides gordonii Ruminococcus callidus than group, but higher Mucispirillum schaedleri . proportions lymphocytes in periphery myeloid cells infiltrating increased Pg-treated animals. addition, solute clearance efficiency system decreased. Neurons hippocampus cortex regions reduced mice treated Pg. Microglia, astrocytes, apoptotic increased. Furthermore, amyloid plaque appeared mice. Conclusions These findings indicate may play role dysbiosis, neuroinflammation, impairment, turn lead

Язык: Английский

---

Targeting gut microbiota to alleviate neuroinflammation in Alzheimer’s disease

Advanced Drug Delivery Reviews, Год журнала: 2022, Номер 188, С. 114418 - 114418

Опубликована: Июль 3, 2022

Язык: Английский

---