Machine Learning to Identify Molecular Markers for Metabolic Disease Development Using Mouse Models DOI Creative Commons

Guiyan Yang,

Rex Liu,

Shahbaz Rezaei

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Март 12, 2023

Abstract Background Aging, Western diet (WD) intake, and bile acid (BA) receptor farnesoid X (FXR) inactivation are risk factors for metabolic disease development including nonalcoholic fatty liver (NAFLD) chronic inflammation-related health issues such as dementia. The progression of the can be escalated when those risks combined. Inactivation FXR is cancer prone in both humans mice. current study used omics data generated within gut-liver axis to classify using bioinformatics machine learning approaches. Methods Different ages (5, 10, 15 months) wild-type (WT) knockout (KO) male mice were fed with either a healthy control (CD) or WD since weaning. Hepatic transcripts, liver, serum, urine metabolites, hepatic acids (BAs), well gut microbiota prediction. A linear support vector K -fold cross-validation was classification feature selection. Results Increased sucrose alone achieved 91% accuracy predicting intake. lithocholic (LCA) serum pyruvate had 100% 95% accuracy, respectively age. Association analyses showed LCA positively associated concentrations acetone, ketone body, 1,3-dihydroxyacetone (DHA), but negatively correlated pyruvate. Urine metabolites (decreased creatinine taurine increased succinate) (increased Dorea, Dehalobacterium , Oscillospira ) could predict functional status greater than 90% accuracy. Integrated pathway revealed that predictors expression implicated central carbon metabolism cancer. To assess translational relevance, mouse transcripts crosschecked human NAFLD hepatocellular carcinoma (HCC) datasets. WD-affected Cyp39a1 Gramd1b HCC NAFLD, respectively. diseases interaction uncovered identified features diseases, mental disorders, Conclusion prediction models contributes identification noninvasive biomarkers early diagnosis development.

Язык: Английский

Therapeutic targeting of obesity-induced neuroinflammation and neurodegeneration DOI Creative Commons
Jialiu Zeng,

Lenny Yi Tong Cheong,

Chih Hung Lo

и другие.

Frontiers in Endocrinology, Год журнала: 2025, Номер 15

Опубликована: Янв. 17, 2025

Obesity is a major modifiable risk factor leading to neuroinflammation and neurodegeneration. Excessive fat storage in obesity promotes the progressive infiltration of immune cells into adipose tissue, resulting release pro-inflammatory factors such as cytokines adipokines. These inflammatory mediators circulate through bloodstream, propagating inflammation both periphery central nervous system. Gut dysbiosis, which results leaky intestinal barrier, exacerbates plays significant role linking pathogenesis neurodegeneration gut-brain/gut-brain-liver axis. Inflammatory states within brain can lead insulin resistance, mitochondrial dysfunction, autolysosomal increased oxidative stress. disruptions impair normal neuronal function subsequently cognitive decline motor deficits, similar pathologies observed neurodegenerative diseases, including Alzheimer's disease, multiple sclerosis, Parkinson's disease. Understanding underlying disease mechanisms crucial for developing therapeutic strategies address defects these metabolic pathways. In this review, we summarize provide insights different strategies, methods alter gut lifestyle changes, dietary supplementation, well pharmacological agents derived from natural sources, that target obesity-induced

Язык: Английский

Процитировано

2
Treatment of Dyslipidemia through Targeted Therapy of Gut Microbiota DOI Open Access

Brandon Flaig,

Rachel Garza,

Bhavdeep Singh

и другие.

Nutrients, Год журнала: 2023, Номер 15(1), С. 228 - 228

Опубликована: Янв. 2, 2023

Dyslipidemia is a multifaceted condition with various genetic and environmental factors contributing to its pathogenesis. Further, this represents an important risk factor for related sequalae including cardiovascular diseases (CVD) such as coronary artery disease (CAD) stroke. Emerging evidence has shown that gut microbiota their metabolites can worsen or protect against the development of dyslipidemia. Although there are currently numerous treatment modalities available lifestyle modification pharmacologic interventions, been promising research on dyslipidemia involves benefits modulating in treating alterations lipid metabolism. In review, we examine relationship between dyslipidemia, impact current dietary prebiotics, probiotics, synbiotics transplant therapeutic prevention disease. Overall, understanding mechanisms by which affect progression will help develop more precise targets optimize

Язык: Английский

Процитировано

31
Connecting the Gut Microbiota and Neurodegenerative Diseases: the Role of Bile Acids DOI

Shixu Wang,

Chongchong Xu, Hongyan Liu

и другие.

Molecular Neurobiology, Год журнала: 2023, Номер 60(8), С. 4618 - 4640

Опубликована: Май 1, 2023

Язык: Английский

Процитировано

24
Inflammatory Response: A Crucial Way for Gut Microbes to Regulate Cardiovascular Diseases DOI Open Access
Wen Wang, Luojiang Zhu,

Yue-Qi Leng

и другие.

Nutrients, Год журнала: 2023, Номер 15(3), С. 607 - 607

Опубликована: Янв. 24, 2023

Gut microbiota is the largest and most complex microflora in human body, which plays a crucial role health disease. Over past 20 years, bidirectional communication between gut extra-intestinal organs has been extensively studied. A better comprehension of alternative mechanisms for physiological pathophysiological processes could pave way health. Cardiovascular disease (CVD) one common diseases that seriously threatens Although previous studies have shown cardiovascular diseases, such as heart failure, hypertension, coronary atherosclerosis, are closely related to microbiota, limited understanding pathogenesis leads poor effectiveness clinical treatment. Dysregulation inflammation always accounts damaged gastrointestinal function deranged interaction with system. This review focuses on characteristics CVD significance regulation during whole process. In addition, strategies prevent treat through proper its metabolites also discussed.

Язык: Английский

Процитировано

21
Novel treatments for anorexia nervosa: Insights from neuroplasticity research DOI Creative Commons
Johanna Louise Keeler, Carol Kan, Janet Treasure

и другие.

European Eating Disorders Review, Год журнала: 2023, Номер 32(6), С. 1069 - 1084

Опубликована: Окт. 12, 2023

Treatment for anorexia nervosa (AN) remains challenging; there are no approved psychopharmacological interventions and psychotherapeutic strategies have variable efficacy. The investigation of evidence-based treatments has so far been compounded by an underdeveloped understanding into the neurobiological changes associated with acute stages AN. There is converging evidence deficiencies in neuroplasticity

Язык: Английский

Процитировано

21
A Mediterranean-style diet protects against cognitive and behavioral deficits, adiposity, and Alzheimer's disease-related markers, compared to a macronutrient-matched typical American diet in C57BL/6J mice DOI Creative Commons

Paige N Braden-Kuhle,

Vivienne A. Lacy, Kelly N Brice

и другие.

Journal of Alzheimer s Disease, Год журнала: 2025, Номер unknown

Опубликована: Фев. 25, 2025

Background Research suggests that modifying risk factors may prevent or delay up to 40% of dementia cases, including Alzheimer's disease (AD). Thus, understanding the potential healthful dietary patterns, like Mediterranean diet (MD), in AD prevention is crucial. While supplementation individual foods has demonstrated efficacy reducing biomarkers and cognitive impairment rodents, effects a comprehensive MD warrant further investigation. Additionally, while rodent studies often use “Western diet” as model for typical American (TAD), these diets generally exceed macronutrient densities consumption, particularly fats carbohydrates. Objective To better reflect human diets, we developed two mice more closely mirrored composition traditional TAD, each with matched profiles (50% kcal from carbohydrates, 35% fat, 15% protein), distinct food sources regions U.S., respectively. Methods Male C57BL/6J were randomly assigned one (MD TAD) at weaning (21 days age), which they consumed six months. Results Compared animals had lower body weight, abdominal hepatic serum TNF-α, central Aβ 1–42 , also exhibiting enhanced exploratory behavior, reduced anxiety-like preserved spatial memory. The protected against LPS-induced inflammation BDNF loss. Conclusions These findings suggest provides protection metabolic AD-related markers wildtype mice, despite caloric availability TAD.

Язык: Английский

Процитировано

0
Microbiota-induced inflammation mediates the impacts of a Western diet on hippocampal-dependent memory DOI

Eden Crain,

Dulce M. Minaya, Claire B. de La Serre

и другие.

Nutrition Research, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Acupuncture modulates the gut microbiota in Alzheimer’s disease: current evidence, challenges, and future opportunities DOI Creative Commons
Long Yan, Hong Li,

Yulin Qian

и другие.

Frontiers in Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Март 1, 2024

Alzheimer’s disease, one of the most severe and common neurodegenerative diseases, has no effective cure. Therefore it is crucial to explore novel therapeutic targets. The gut microbiota - brain axis been found play a role in disease by regulating neuro-immune endocrine systems. At same time, acupuncture can modulate may impact course disease. In this Review, we discuss recent studies on as well current challenges future opportunities potential treatment for prevention

Язык: Английский

Процитировано

3
Gut microbiota: the indispensable player in neurodegenerative diseases DOI
Sen Li, Yuwei Cai, Shuo Wang

и другие.

Journal of the Science of Food and Agriculture, Год журнала: 2024, Номер 104(12), С. 7096 - 7108

Опубликована: Апрель 4, 2024

As one of the most urgent social and health problems in world, neurodegenerative diseases have always been interest to researchers. However, pathological mechanisms therapeutic approaches are not achieved. In addition established roles oxidative stress, inflammation immune response, changes gut microbiota also closely related pathogenesis diseases. Gut is central player gut-brain axis, dynamic bidirectional communication pathway between nervous system, emerging insights confirmed its indispensability development this review, we discuss complex relationship system from perspective axis; review mechanism for modulation different how dietary patterns affect via microbiota; prospect employment approach those © 2024 Society Chemical Industry.

Язык: Английский

Процитировано

3
Uncovering the Gut–Liver Axis Biomarkers for Predicting Metabolic Burden in Mice DOI Open Access

Guiyan Yang,

Rex Liu,

Shahbaz Rezaei

и другие.

Nutrients, Год журнала: 2023, Номер 15(15), С. 3406 - 3406

Опубликована: Июль 31, 2023

Western diet (WD) intake, aging, and inactivation of farnesoid X receptor (FXR) are risk factors for metabolic chronic inflammation-related health issues ranging from dysfunction-associated steatotic liver disease (MASLD) to dementia. The progression MASLD can be escalated when those risks combined. Inactivation FXR, the bile acid (BA), is cancer prone in both humans mice. current study used multi-omics including hepatic transcripts, liver, serum, urine metabolites, BAs, as well gut microbiota mouse models classify using machine learning. A linear support vector with

Язык: Английский

Процитировано

8