Translational Frontiers and Clinical Opportunities of Immunologically Fitted Radiotherapy

Clinical Cancer Research, Год журнала: 2024, Номер 30(11), С. 2317 - 2332

Опубликована: Март 13, 2024

Abstract Ionizing radiation can have a wide range of impacts on tumor–immune interactions, which are being studied with the greatest interest and at an accelerating pace by medical community. Despite its undeniable immunostimulatory potential, it clearly appears that radiotherapy as is prescribed delivered nowadays often alters host's immunity toward suboptimal state. This may impair full recovery sustained efficient antitumor immunosurveillance posttreatment. An emerging concept arising from this awareness consists reconsidering way designing treatment planning, notably taking into account individualized risks deleterious radio-induced immune alteration be deciphered planned beam trajectory through lymphocyte-rich organs. In review, we critically appraise key aspects to consider while planning immunologically fitted radiotherapy, including challenges linked identification new dose constraints immune-rich structures. We also discuss how pharmacologic immunomodulation could advantageously used in combination compensate for loss, example, (i) agonists interleukin (IL)2, IL4, IL7, IL9, IL15, or IL21, similarly G-CSF prophylaxis severe chemo-induced neutropenia, (ii) myeloid-derived suppressive cell blockers.

Язык: Английский

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Mechanisms and Strategies of Immunosenescence Effects on Non-Small Cell Lung Cancer (NSCLC) Treatment: A Comprehensive Analysis and Future Directions

Seminars in Cancer Biology, Год журнала: 2025, Номер 109, С. 44 - 66

Опубликована: Янв. 9, 2025

Язык: Английский

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Pathogenesis of influenza and SARS-CoV-2 co-infection at the extremes of age: decipher the ominous tales of immune vulnerability

Advanced Biotechnology, Год журнала: 2025, Номер 3(1)

Опубликована: Янв. 21, 2025

The co-circulation of influenza and SARS-CoV-2 has led to co-infection events, primarily affecting children older adults, who are at higher risk for severe disease. Although prevalence is relatively low, it associated with worse outcomes compared mono-infections. Previous studies have shown that the depend on multiple factors, including viral interference, virus-host interaction host response. Children elderly exhibit distinct patterns antiviral response, which involve airway epithelium, mucociliary clearance, innate adaptive immune cells, inflammatory mediators. This review explores pathogeneses co-infection, focusing responses in elderly. By comparing immature immunity senescence we aim provide insights clinical management cases.

Язык: Английский

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A researcher's guide to studying sex differences in immune aging

Trends in Molecular Medicine, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Cellular Senescence as a Key Player in Chronic Heart Failure Pathogenesis: Unraveling Mechanisms and Therapeutic Opportunities

Progress in Biophysics and Molecular Biology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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