Cellular Senescence as a Key Player in Chronic Heart Failure Pathogenesis: Unraveling Mechanisms and Therapeutic Opportunities DOI Creative Commons
Shuqing Zhao, Yu Zhang, Ying Zhao

et al.

Progress in Biophysics and Molecular Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Translational Frontiers and Clinical Opportunities of Immunologically Fitted Radiotherapy DOI Creative Commons
Daphné Morel, Charlotte Robert, Nikos Paragios

et al.

Clinical Cancer Research, Journal Year: 2024, Volume and Issue: 30(11), P. 2317 - 2332

Published: March 13, 2024

Abstract Ionizing radiation can have a wide range of impacts on tumor–immune interactions, which are being studied with the greatest interest and at an accelerating pace by medical community. Despite its undeniable immunostimulatory potential, it clearly appears that radiotherapy as is prescribed delivered nowadays often alters host's immunity toward suboptimal state. This may impair full recovery sustained efficient antitumor immunosurveillance posttreatment. An emerging concept arising from this awareness consists reconsidering way designing treatment planning, notably taking into account individualized risks deleterious radio-induced immune alteration be deciphered planned beam trajectory through lymphocyte-rich organs. In review, we critically appraise key aspects to consider while planning immunologically fitted radiotherapy, including challenges linked identification new dose constraints immune-rich structures. We also discuss how pharmacologic immunomodulation could advantageously used in combination compensate for loss, example, (i) agonists interleukin (IL)2, IL4, IL7, IL9, IL15, or IL21, similarly G-CSF prophylaxis severe chemo-induced neutropenia, (ii) myeloid-derived suppressive cell blockers.

Language: Английский

Citations

5
Mechanisms and Strategies of Immunosenescence Effects on Non-Small Cell Lung Cancer (NSCLC) Treatment: A Comprehensive Analysis and Future Directions DOI
Huatao Zhou,

Zilong Zheng,

Chengming Fan

et al.

Seminars in Cancer Biology, Journal Year: 2025, Volume and Issue: 109, P. 44 - 66

Published: Jan. 9, 2025

Language: Английский

Citations

0
Pathogenesis of influenza and SARS-CoV-2 co-infection at the extremes of age: decipher the ominous tales of immune vulnerability DOI Creative Commons

Kailin Mai,

Weiqi Pan,

Zhengshi Lin

et al.

Advanced Biotechnology, Journal Year: 2025, Volume and Issue: 3(1)

Published: Jan. 21, 2025

The co-circulation of influenza and SARS-CoV-2 has led to co-infection events, primarily affecting children older adults, who are at higher risk for severe disease. Although prevalence is relatively low, it associated with worse outcomes compared mono-infections. Previous studies have shown that the depend on multiple factors, including viral interference, virus-host interaction host response. Children elderly exhibit distinct patterns antiviral response, which involve airway epithelium, mucociliary clearance, innate adaptive immune cells, inflammatory mediators. This review explores pathogeneses co-infection, focusing responses in elderly. By comparing immature immunity senescence we aim provide insights clinical management cases.

Language: Английский

Citations

0
A researcher's guide to studying sex differences in immune aging DOI
Clayton Baker, Minhoo Kim, Bérénice A. Benayoun

et al.

Trends in Molecular Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Cellular Senescence as a Key Player in Chronic Heart Failure Pathogenesis: Unraveling Mechanisms and Therapeutic Opportunities DOI Creative Commons
Shuqing Zhao, Yu Zhang, Ying Zhao

et al.

Progress in Biophysics and Molecular Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0