Cognitively challenging physical activity benefits executive function in overweight children
Journal of Sports Sciences,
Год журнала:
2013,
Номер
32(3), С. 201 - 211
Опубликована: Сен. 9, 2013
This
study
tested
the
association
between
aerobic
fitness
and
executive
function
impact
of
enhanced,
cognitively
challenging
physical
activity
on
in
overweight
lean
children.
Seventy
children
aged
9–10
years
were
assigned
to
either
a
6-month
enhanced
education
programme
including
demanding
(open
skill)
activities
or
curricular
only.
Pre-
post-intervention
tests
assessed
capacity
(Leger
test)
two
components
function:
inhibition
working
memory
updating
(random
number
generation
task).
Indices
compared
higher-
lower-fit
intervention
effects
evaluated
as
(enhanced
vs.
curricular)
weight
status
(lean
overweight).
Results
showed
better
than
children,
extending
existing
evidence
new
aspects
children’s
inhibitory
ability.
Overweight
had
more
pronounced
pre-
improvements
only
if
involved
education.
Such
not
mediated
by
gains.
Therefore,
cognitive
social
interaction
challenges
inherent
open
skill
tasks,
even
though
embedded
low-dose
programme,
may
represent
an
effective
means
promote
efficiency,
especially
Язык: Английский
The neuroplastic brain: current breakthroughs and emerging frontiers
Brain Research,
Год журнала:
2025,
Номер
unknown, С. 149643 - 149643
Опубликована: Апрель 1, 2025
Язык: Английский
Photobiomodulation of Neurogenesis through the Enhancement of Stem Cell and Neural Progenitor Differentiation in the Central and Peripheral Nervous Systems
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(20), С. 15427 - 15427
Опубликована: Окт. 21, 2023
Photobiomodulation
(PBM)
is
the
regulation
of
biological
processes
using
light
energy
from
sources
such
as
lasers
or
light-emitting
diodes.
Components
nervous
system,
brain
and
peripheral
nerves,
are
important
candidate
PBM
targets
due
to
lack
therapeutic
modalities
for
complete
cure
neurological
diseases.
can
be
applied
either
regenerate
damaged
organs
prevent
reduce
damage
caused
by
disease.
Although
recent
findings
have
suggested
that
neural
cells
regenerated,
which
contradicts
our
previous
understanding,
structures
still
thought
weaker
regenerative
capacity
than
other
systems.
Therefore,
enhancing
system
would
aid
future
development
therapeutics
degeneration.
has
been
shown
enhance
cell
differentiation
stem
progenitor
near-target
target
cells.
In
this
review,
we
reviewed
research
on
effects
neurogenesis
in
central
(e.g.,
animal
brains)
sensory
structures)
sought
its
potential
a
tool
intractable
degenerative
disorders.
Язык: Английский
Nissl Granules, Axonal Regeneration, and Regenerative Therapeutics: A Comprehensive Review
Cureus,
Год журнала:
2023,
Номер
unknown
Опубликована: Окт. 28, 2023
Nissl
granules,
traditionally
recognized
for
their
pivotal
role
in
protein
synthesis
within
neuronal
cell
bodies,
are
emerging
as
intriguing
components
with
far-reaching
implications
the
realm
of
regenerative
therapeutics.
This
abstract
encapsulates
essence
a
comprehensive
review,
exploring
nexus
between
axonal
regeneration,
and
transformative
applications
medicine.
The
molecular
intricacies
granules
form
foundation
this
exploration,
unraveling
dynamic
orchestrating
cellular
responses,
particularly
context
regeneration.
As
we
delve
into
interplay
processes,
review
highlights
diverse
mechanisms
through
which
these
contribute
to
repair
recovery.
Beyond
conventional
association
neurobiology,
recent
advancements
underscore
translational
potential
therapeutic
agents.
Insights
involvement
enhancing
regeneration
prompt
reconsideration
key
players
broader
field
evidence
suggesting
that
modulating
granule-related
pathways
holds
promise
augmenting
tissue
extending
applicability
beyond
confines
nervous
system.
aims
serve
valuable
resource
medical
professionals,
researchers,
clinicians
seeking
comprehend
multifaceted
By
illuminating
intricate
connections
applications,
work
aspires
catalyze
further
research
innovation,
ultimately
contributing
evolution
strategies
harness
innate
reparative
capacities
constituents.
Язык: Английский
Current progress and challenges in the development of brain tissue models: How to grow up the changeable brain in vitro?
Journal of Tissue Engineering,
Год журнала:
2024,
Номер
15
Опубликована: Янв. 1, 2024
In
vitro
modeling
of
brain
tissue
is
a
promising
but
not
yet
resolved
problem
in
modern
neurobiology
and
neuropharmacology.
Complexity
the
structure
diversity
cell-to-cell
communication
(patho)physiological
conditions
make
this
task
almost
unachievable.
However,
establishment
novel
models
would
ultimately
lead
to
better
understanding
development-associated
or
experience-driven
plasticity,
designing
efficient
approaches
restore
aberrant
functioning.
The
main
goal
review
summarize
available
data
on
methodological
that
are
currently
use,
identify
most
prospective
trends
development
neurovascular
unit,
blood-brain
barrier,
blood-cerebrospinal
fluid
neurogenic
niche
models.
manuscript
focuses
regulation
adult
neurogenesis,
cerebral
microcirculation
fluids
dynamics
should
be
reproduced
4D
mimic
its
alterations
pathology.
We
discuss
critical
for
studying
deciphering
individual
person-specific
trajectory
aging,
testing
new
drug
candidates
Язык: Английский
Modifying Alzheimer’s disease pathophysiology with photobiomodulation: model, evidence, and future with EEG-guided intervention
Frontiers in Neurology,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 23, 2024
This
manuscript
outlines
a
model
of
Alzheimer’s
Disease
(AD)
pathophysiology
in
progressive
layers,
from
its
genesis
to
the
development
biomarkers
and
then
symptom
expression.
Genetic
predispositions
are
major
factor
that
leads
mitochondrial
dysfunction
subsequent
amyloid
tau
protein
accumulation,
which
have
been
identified
as
hallmarks
AD.
Extending
beyond
these
accumulations,
we
explore
broader
spectrum
pathophysiological
aspects,
including
blood–brain
barrier,
blood
flow,
vascular
health,
gut-brain
microbiodata,
glymphatic
metabolic
syndrome,
energy
deficit,
oxidative
stress,
calcium
overload,
inflammation,
neuronal
synaptic
loss,
brain
matter
atrophy,
reduced
growth
factors.
Photobiomodulation
(PBM),
delivers
near-infrared
light
selected
regions
using
portable
devices,
is
introduced
therapeutic
approach.
PBM
has
potential
address
each
with
data
provided
by
various
studies.
They
provide
mechanistic
support
for
largely
small
published
clinical
studies
demonstrate
improvements
memory
cognition.
inform
PBM’s
treat
AD
pending
validation
large
randomized
controlled
The
presentation
network
waveform
changes
on
electroencephalography
(EEG)
opportunity
use
guide
application
parameters
improve
outcomes.
These
include
wavelength,
power
density,
treatment
duration,
LED
positioning,
pulse
frequency.
Pulsing
at
specific
frequencies
found
influence
expression
waveforms
modifications
networks.
stems
modulation
cellular
structures
revealed
recent
findings
an
EEG-based
artificial
intelligence
personalize
through
EEG
feedback.
Язык: Английский
Neuroprotective Effect of Solid Lipid Nanoparticles Loaded with Lepidium sativum (L.) Seed Bioactive Components Enhance Bioavailability and Wnt/β-Catenin/Camk-II Signaling Cascade in SH-SY5Y Neuroblastoma Cells
Nanomaterials,
Год журнала:
2024,
Номер
14(2), С. 199 - 199
Опубликована: Янв. 16, 2024
The
primary
pathological
hallmark
of
Alzheimer’s
disease
(AD)
is
the
formation
and
accumulation
neurofibrillary
tangles
plaques,
which
result
from
aggregation
amyloid-β
(Aβ)
induced
by
oxidative
stress.
effectiveness
therapeutics
significantly
hinges
on
drug’s
bioavailability
its
ability
to
penetrate
neuronal
cells.
current
investigation
was
designed
as
a
first
attempt
examine
bio-fabricated
Lepidium
sativum
(LS)
seed-extract-loaded
solid
lipid
nanoparticles
(SLNps)
increase
bioefficacy
for
prevention
undifferentiated
SH-SY5Y
cells
stress
H2O2
peptide
(Aβ,1-42).
SLNps
were
fabricated
using
LS
extract
water
phase
hyaluronic
acid
chia
seed
fatty
acids
phase,
then
confirmed
characterized
UV,
Zeta
size,
SEM
methods.
biological
safety
synthesized
LS-SLNps
has
been
determined
MTT
assay
PI
staining
(nuclear
damage)
in
hMSCs.
LS-SLNp-pretreated
with
2
µM
beta-amyloid
(Aβ,1-42)
fibrils;
furthermore,
neuroprotective
potential
through
quenching
stress,
enhancing
mitochondrial
capacity,
immunoregulatory
potential.
Observations
found
that
treated
both
fibrils
showed
decreased
cell
growth,
nuclear
damage,
membrane
due
However,
pretreated
24
h
an
proliferation
uniform
morphology
increased
compared
alone.
Gene
expression
analysis
Wnt
3a
5a,
stimulated
canonical,
β-catenin,
non-canonical
Camk-II
expressions
nerve
growth
factors,
confirming
molecular-level
reversal
neurodegenerative
diseases.
Язык: Английский
Exploring the triad: VPS35, neurogenesis, and neurodegenerative diseases
Journal of Neurochemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 18, 2024
Abstract
Vacuolar
protein
sorting
35
(VPS35),
a
critical
component
of
the
retromer
complex,
plays
pivotal
role
in
pathogenesis
neurodegenerative
diseases
(NDs).
It
is
involved
transmembrane
sorting,
facilitating
transport
from
endosomes
to
trans‐Golgi
network
(TGN)
and
plasma
membrane.
Recent
investigations
have
compellingly
associated
mutations
VPS35
gene
with
disorders
such
as
Parkinson's
Alzheimer's
disease.
These
genetic
alterations
are
implicated
misfolding,
disrupted
autophagic
processes,
mitochondrial
dysregulation,
synaptic
impairment.
Furthermore,
exerts
notable
impact
on
neurogenesis
by
influencing
neuronal
functionality,
conveyance,
performance.
Dysregulation
or
mutation
may
escalate
progression
conditions,
underscoring
its
safeguarding
integrity.
This
review
comprehensively
discusses
functional
impairments
NDs.
we
provide
an
overview
further
explore
intricate
relationship
between
research
advancements
offer
novel
perspectives
valuable
insights
for
identifying
potential
therapeutic
targets
treatment
image
Язык: Английский
Lactylation and Ischemic Stroke: Research Progress and Potential Relationship
Molecular Neurobiology,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 14, 2024
Язык: Английский
Effects of Physical Activity on Pakinson's Disease Patients
Advances in medical diagnosis, treatment, and care (AMDTC) book series,
Год журнала:
2023,
Номер
unknown, С. 275 - 295
Опубликована: Авг. 4, 2023
Parkinson's
disease
(PD)
is
the
most
common
movement
disorder
worldwide,
of
which
neuroprotective
or
neurorestorative
therapy
not
yet
available.
The
current
line
treatments
are
believed
to
be
effective
in
alleviating
PD
symptoms,
but
as
progress,
various
complications
appear,
and
treatment
becomes
challenging.
Hence,
role
nonpharmacologic
therapies
great
interest
can
useful
delay
slow
progression.
Increasing
evidence
shows
important
physical
activity
(PA)
management
even
prevention
disease.
Several
mechanisms
thought
explain
beneficial
effect
exercise
PD.
However,
exact
neurobiological
underpinning
this
benefit
fully
understood.
This
chapter
will
discuss
patients
possible
molecular
by
PA
could
lead
these
effects.
Язык: Английский