Neuroscience, Год журнала: 2024, Номер 563, С. 84 - 92
Опубликована: Ноя. 8, 2024
Язык: Английский
Cancer Letters, Год журнала: 2023, Номер 561, С. 216152 - 216152
Опубликована: Апрель 4, 2023
Язык: Английский
Процитировано
38
Brain Research, Год журнала: 2024, Номер 1835, С. 148919 - 148919
Опубликована: Апрель 6, 2024
Язык: Английский
Процитировано
9
Journal of Neuroimmune Pharmacology, Год журнала: 2025, Номер 20(1)
Опубликована: Янв. 11, 2025
Язык: Английский
Процитировано
1
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Апрель 11, 2024
Ferroptosis is an emerging mode of programmed cell death fueled by iron buildup and lipid peroxidation. Recent evidence points to the function ferroptosis in aetiology development cancer other disorders. Consequently, harnessing for disease treatment has diverted interest researchers field basic clinical research. The ubiquitin-proteasome system (UPS) represents a primary protein degradation pathway eukaryotes. It involves labelling proteins be degraded ubiquitin (Ub), followed recognition proteasome. Dysfunction UPS can contribute diverse pathological processes, emphasizing importance maintaining organismal homeostasis. regulation stability critical component intricate molecular mechanism underlying death. Moreover, involvement regulating death-related molecules signaling pathways, providing valuable insights targeted strategies. Besides, it highlights potential as promising target therapy, combination between UPS. mechanisms ferroptosis, including key regulators such glutathione peroxidase 4 (GPX4), cysteine/glutamate transporter (system XC-), metabolism, are thoroughly examined, alongside role modulating abundance activity crucial ferroptotic death, GPX4, nuclear factor erythroid 2–related 2 (NRF2). As pivotal regulatory macromolecular homeostasis, substantially impacts directly or indirectly associated pathways. This review explores diseases with ferroptosis.
Язык: Английский
Процитировано
7
Behavioural Brain Research, Год журнала: 2024, Номер 473, С. 115198 - 115198
Опубликована: Авг. 10, 2024
Язык: Английский
Процитировано
5
Clinical and Experimental Medicine, Год журнала: 2025, Номер 25(1)
Опубликована: Фев. 1, 2025
Growing research reveals that circular RNAs (circRNAs) play a major part in the progression and development of cancer. Here, we investigated oncogenic function regulatory mechanisms circRNA circACTN4 hepatocellular carcinoma (HCC), particularly tumor epithelial-mesenchymal transition (EMT). In vitro functional assays (Cell Counting Kit 8, TUNEL, scratch wound healing, invasion assays) HCC cell lines, alongside vivo analyses subcutaneous tumors nude model mice, were employed to assess impact on proliferation. Interactions concerning circACTN4, microRNA (miR)-424-5p, non-SMC condensing I complex subunit G (NCAPG) have been assessed deploying luciferase reporter also quantitative reverse transcription PCR investigation transcripts tissues. Findings indicated high expression HCC, promoted proliferation, while inhibiting apoptosis cells, correlated with poor prognosis. Mechanistically, served as rival internal RNA for miR-424 5p, controlling NCAPG level initiating Wnt/β-catenin signaling routes, which turn impacted EMT machinery HCC. According our surveys, circACTN4/miR-424 5p/NCAPG axis could be an intriguing candidate therapy address treatment
Язык: Английский
Процитировано
0
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Год журнала: 2025, Номер unknown, С. 111287 - 111287
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Neurochemistry International, Год журнала: 2025, Номер unknown, С. 105949 - 105949
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Cellular Neuroscience, Год журнала: 2025, Номер 19
Опубликована: Март 10, 2025
In recent years, the study of phosphatase and tension homolog (PTEN) has gradually become a research hotspot. As an important oncogene, role PTEN in cancer long been widely recognized intensively studied, but it relatively less studied other diseases. Parkinson’s disease (PD) is neurodegenerative refractory commonly observed middle-aged elderly individuals. The etiology pathogenesis PD are numerous, complex, incompletely understood. With continuous deepening research, numerous studies have proven that related to occurrence PD. this review, we discuss relationship between through phosphorylation ubiquitination possible regulatory mechanisms, including RNA molecules, exosomes, transcriptional regulation, chemical modification, subtype variation, with aim clarifying better elucidating its pathogenesis. Finally, summarize shortcomings highlight great potential future application clinical treatment. These findings provide ideas new perspectives for use as therapeutic target targeted drug development future.
Язык: Английский
Процитировано
0
Brain Research Bulletin, Год журнала: 2024, Номер 209, С. 110910 - 110910
Опубликована: Фев. 27, 2024
Ischemic stroke is one of the leading causes death and disability globally, but its treatment options are limited due to therapeutic window reperfusion injury constraints. Microglia, astrocytes, oligodendrocytes major components neurovascular unit, there substantial evidence suggesting their contributions maintaining homeostasis in central nervous system. Neuroglial cells participate neuronal physiological functions repair damaged neurons through various communication methods, including gap junctions, chemical signaling, extracellular vesicles, conjunction with other unit. Ischemia-induced microglia astrocytes polarize into "M1/M2" "A1/A2" phenotypes exert neurotoxic or neuroprotective effects by releasing soluble factors, secreting forming syncytia networks acute (<72 h), subacute (>72 chronic phases (>6 weeks). Apoptosis ischemic hypoxia leads white matter injury, causing long-term cognitive dysfunction, promoting oligodendrogenesis a crucial direction for achieving functional recovery stroke. In this article, we summarize cellular interactions following cerebral ischemia, analyze roles neuroglial vesicles different stages stroke, further explore strategies intervening
Язык: Английский
Процитировано
3