Nature Reviews Disease Primers, Год журнала: 2024, Номер 10(1)
Опубликована: Окт. 24, 2024
Язык: Английский
Процитировано
7A New Device and Method for Endothelial Graft Preparation in Descemet Membrane Endothelial Keratoplasty (DMEK): A Preliminary Feasibility and Technical Evaluation
Cureus, Год журнала: 2025, Номер unknown
Опубликована: Янв. 2, 2025
This study compares the preparation time and macroscopic integrity of Descemet membrane endothelium keratoplasty (DMEK) grafts prepared using modified submerged cornea backgrounds away (SCUBA) technique compared to those with a newly developed artificial chamber device specifically designed for DMEK preparation. is prospective, comparative, randomized, experimental study. Fifty corneas from 25 donors were used. The inclusion criteria that both eyes same donor, scleral ring greater than 3 mm, unsuitable clinical use. Preparation tissue evaluated at end mean techniques was six minutes (p=0.2). graft similar between inverted SCUBA (p=1.00). upside-down operating proved reproducible macroscopically suitable endothelial technique.
Язык: Английский
Процитировано
0Looking to the Future of Viral Vectors in Ocular Gene Therapy: Clinical Review
Biomedicines, Год журнала: 2025, Номер 13(2), С. 365 - 365
Опубликована: Фев. 5, 2025
Eye diseases can significantly affect the quality of life patients due to decreased visual acuity. Although modern ophthalmological diagnostic methods exist, some system are asymptomatic in early stages. Most seek advice from an ophthalmologist as a result rapidly progressive manifestation symptoms. A number inherited and acquired eye have only supportive treatment without eliminating etiologic factor. promising solution this problem may be gene therapy, which has proven efficacy safety shown clinical studies. By directly altering or replacing defective genes, therapeutic approach will stop well reverse progression diseases. This review examines concept therapy its application field ocular pathologies, emphasizing most recent scientific advances their potential impacts on function status.
Язык: Английский
Процитировано
0PROTAC based targeted degradation of LRG1 for mitigating corneal neovascularization
Journal of Controlled Release, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0A historical view of the development of corneal transplantation: from penetrating keratoplasty to selective transplantation of the finest corneal layers
Wiener Medizinische Wochenschrift, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0Corneal endothelial dysfunction treatments: Recent advances in non-invasive treatment strategies
Nano Today, Год журнала: 2025, Номер 63, С. 102740 - 102740
Опубликована: Апрель 4, 2025
Язык: Английский
Процитировано
0Recent developments in gene therapy research in India
Journal of Biosciences, Год журнала: 2024, Номер 49(1)
Опубликована: Фев. 20, 2024
Язык: Английский
Процитировано
2Recent Advancements and Applications of Ophthalmic Gene Therapy Strategies: A Breakthrough in Ocular Therapeutics
Experimental Eye Research, Год журнала: 2024, Номер 245, С. 109983 - 109983
Опубликована: Июнь 26, 2024
Язык: Английский
Процитировано
2Ocular Gene Therapy: An Overview of Viral Vectors, Immune Responses, and Future Directions
The Yale Journal of Biology and Medicine, Год журнала: 2024, Номер 97(4), С. 491 - 503
Опубликована: Дек. 19, 2024
Ocular gene therapy has rapidly advanced from proof-of-concept studies to clinical trials by exploiting the unique advantages of eye, including its easy accessibility, relative immune privilege, and ability use contralateral eye as a control. An important step forward was achieved with Food Drug Administration (FDA) approval voretigene neparvovec (Luxturna) for treatment biallelic RPE65-mutation-associated retinal dystrophies in 2017. Gene is promising field aimed at treating various inherited acquired diseases. Viral vectors such adeno-associated virus (AAV) are mainly used efficiently deliver genes. Despite immune-privileged status viral vector-based therapies can induce responses, potentially leading therapy-associated uveitis. Future directions include developing strategies reduce responses while maintaining therapeutic efficacy, optimizing vector selection, improving delivery techniques. Continued advances vectors, particularly AAV, expanding potential applications treat variety ocular To fully realize therapy, more research needed improve these methods, ensure safe efficient treatments, ultimately overcome existing obstacles.
Язык: Английский
Процитировано
2Restoration of corneal epithelial barrier function: A possible target for corneal neovascularization
The Ocular Surface, Год журнала: 2024, Номер 34, С. 38 - 49
Опубликована: Июнь 18, 2024
Язык: Английский
Процитировано
1