The role of astrocyte metabolic reprogramming in ischemic stroke (Review)
International Journal of Molecular Medicine,
Год журнала:
2025,
Номер
55(3)
Опубликована: Янв. 21, 2025
Ischemic
stroke,
a
leading
cause
of
disability
and
mortality
worldwide,
is
characterized
by
the
sudden
loss
blood
flow
in
specific
area
brain.
Intravenous
thrombolysis
with
recombinant
tissue
plasminogen
activator
only
approved
pharmacological
treatment
for
acute
ischemic
stroke;
however,
aforementioned
has
significant
clinical
limitations,
thus
there
an
urgent
need
development
novel
mechanisms
therapeutic
strategies
stroke.
Astrocytes,
abundant
versatile
cells
central
nervous
system,
offer
crucial
support
to
neurons
nutritionally,
structurally
physically.
They
also
contribute
blood‑brain
barrier
formation
regulate
neuronal
extracellular
ion
concentrations.
Accumulated
evidence
revealed
involvement
astrocytes
regulation
host
neurotransmitter
metabolism,
immune
response
repair,
different
metabolic
characteristics
can
process
suggesting
that
targeted
astrocyte
reprogramming
may
prognosis
In
present
review,
current
understanding
multifaceted
along
its
regulatory
factors
pathways,
as
well
promote
polarization
balance,
which
hold
promise
immunometabolism‑targeted
therapies
were
summarized.
Язык: Английский
Lysosomal acidification impairment in astrocyte-mediated neuroinflammation
Journal of Neuroinflammation,
Год журнала:
2025,
Номер
22(1)
Опубликована: Март 10, 2025
Abstract
Astrocytes
are
a
major
cell
type
in
the
central
nervous
system
(CNS)
that
play
key
role
regulating
homeostatic
functions,
responding
to
injuries,
and
maintaining
blood-brain
barrier.
also
regulate
neuronal
functions
survival
by
modulating
myelination
degradation
of
pathological
toxic
protein
aggregates.
have
recently
been
proposed
possess
both
autophagic
activity
active
phagocytic
capability
which
largely
depend
on
sufficiently
acidified
lysosomes
for
complete
cellular
cargos.
Defective
lysosomal
acidification
astrocytes
impairs
their
resulting
accumulation
debris,
excessive
myelin
lipids,
aggregates,
ultimately
contributes
propagation
neuroinflammation
neurodegenerative
pathology.
Restoration
impaired
represent
new
neuroprotective
strategy
therapeutic
direction.
In
this
review,
we
summarize
pathogenic
factors,
including
neuroinflammatory
signaling,
metabolic
stressors,
lipid
mediated
toxicity,
contribute
impairment
associated
dysfunction
astrocytes.
We
discuss
astrocyte-mediated
primarily
context
diseases
along
with
other
brain
injuries.
then
highlight
re-acidification
as
restore
well
degradative
capacity
conclude
providing
future
perspectives
phagocytes
crosstalk
CNS
cells
impart
or
effects.
Язык: Английский
Research on the signaling pathways related to the intervention of traditional Chinese medicine in Parkinson's disease:A literature review
Journal of Ethnopharmacology,
Год журнала:
2024,
Номер
326, С. 117850 - 117850
Опубликована: Фев. 6, 2024
Язык: Английский
The Role of Astrocytes and Alpha-Synuclein in Parkinson’s Disease: A Review
NeuroSci,
Год журнала:
2024,
Номер
5(1), С. 71 - 86
Опубликована: Март 8, 2024
The
search
for
new
therapies
to
reduce
symptoms
and
find
a
cure
Parkinson’s
disease
has
focused
attention
on
two
key
points:
the
accumulation
of
alpha-synuclein
aggregates
astrocytes.
former
is
hallmark
disease,
while
latter
corresponds
type
glial
cell
with
an
important
role
in
both
prevention
development
this
neurodegenerative
disorder.
Traditionally,
research
targeting
dopaminergic
neurons.
Currently,
as
more
known
about
genetic
molecular
factors
neuroglial
interaction
great
emphasis
been
placed
neuroprotective
astrocytes
early
stages
astrocytic
capture
under
physiological
pathological
conditions.
This
review
aims
analyze
contribution
progression
well
evaluate
recent
therapeutic
proposals
specifically
synucleopathies
astroglial
cells
potential
disease.
Язык: Английский
Intercellular Adhesion Molecule 1 (ICAM-1): An Inflammatory Regulator with Potential Implications in Ferroptosis and Parkinson’s Disease
Cells,
Год журнала:
2024,
Номер
13(18), С. 1554 - 1554
Опубликована: Сен. 15, 2024
Intercellular
adhesion
molecule
1
(ICAM-1/CD54),
a
transmembrane
glycoprotein,
has
been
considered
as
one
of
the
most
important
molecules
during
leukocyte
recruitment.
It
is
encoded
by
ICAM1
gene
and
plays
central
role
in
inflammation.
Its
crucial
many
inflammatory
diseases
such
ulcerative
colitis
rheumatoid
arthritis
are
well
established.
Given
that
neuroinflammation,
underscored
microglial
activation,
key
element
neurodegenerative
Parkinson’s
disease
(PD),
we
investigated
whether
ICAM-1
this
progressive
neurological
condition
and,
if
so,
to
elucidate
underpinning
mechanisms.
Specifically,
were
interested
potential
interaction
between
ICAM-1,
glial
cells,
ferroptosis,
an
iron-dependent
form
cell
death
recently
implicated
PD.
We
conclude
there
exist
direct
indirect
(via
cells
T
cells)
influences
on
ferroptosis
further
elucidation
these
interactions
can
suggest
novel
intervention
for
devastating
disease.
Язык: Английский
IPSC-Derived Astrocytes Contribute to In Vitro Modeling of Parkinson’s Disease Caused by the GBA1 N370S Mutation
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
25(1), С. 327 - 327
Опубликована: Дек. 26, 2023
Parkinson's
disease
(PD)
is
a
neurodegenerative
disorder
that
ranks
second
in
prevalence
after
Alzheimer's
disease.
The
number
of
PD
diagnoses
increases
annually.
Nevertheless,
modern
treatments
merely
mitigate
symptoms
rather
than
preventing
neurodegeneration
progression.
creation
an
appropriate
model
to
thoroughly
study
the
mechanisms
pathogenesis
remains
current
challenge
biomedicine.
Recently,
there
has
been
increase
data
regarding
involvement
not
only
dopaminergic
neurons
substantia
nigra
but
also
astrocytes
PD.
Cell
models
based
on
induced
pluripotent
stem
cells
(iPSCs)
and
their
differentiated
derivatives
are
useful
tool
for
studying
contribution
interaction
these
two
cell
types
Here,
we
generated
iPSC
lines,
ICGi034-B
ICGi034-C,
by
reprogramming
peripheral
blood
mononuclear
patient
with
heterozygous
mutation
c.1226A>G
(p.N370S)
GBA1
gene
non-integrating
episomal
vectors
encoding
OCT4,
KLF4,
L-MYC,
SOX2,
LIN28,
mp53DD.
lines
demonstrate
expression
pluripotency
markers
capable
differentiating
into
three
germ
layers.
We
ICGi034-C
astrocytes.
This
resulting
can
be
used
GBA-associated
Язык: Английский
Double-edged effect of astrocyte in the transition of physiopathological states in Parkinson’s disease
Chaos Solitons & Fractals,
Год журнала:
2024,
Номер
185, С. 115154 - 115154
Опубликована: Июнь 20, 2024
Язык: Английский
The mechanisms of white matter injury and immune system crosstalk in promoting the progression of Parkinson’s disease: a narrative review
Frontiers in Aging Neuroscience,
Год журнала:
2024,
Номер
16
Опубликована: Май 28, 2024
Parkinson’s
disease
(PD)
is
neurodegenerative
in
middle-aged
and
elderly
people
with
some
pathological
mechanisms
including
immune
disorder,
neuroinflammation,
white
matter
injury
abnormal
aggregation
of
alpha-synuclein,
etc.
New
research
suggests
that
may
be
important
the
development
PD,
but
how
inflammation,
system,
damage
interact
to
harm
dopamine
neurons
not
yet
understood.
Therefore,
it
particularly
delve
into
crosstalk
between
cells
central
peripheral
nervous
system
based
on
study
PD.
This
could
only
exacerbate
process
PD
also
reveal
new
therapeutic
targets.
By
understanding
penetrate
through
blood–brain
barrier
activate
inflammatory
responses
within
we
can
better
grasp
impact
structural
destruction
explore
this
modulated
mitigate
or
combat
progression.
Microglia,
astrocytes,
oligodendrocytes
(especially
T
cells)
play
a
role
its
where
these
produce
respond
pro-inflammatory
cytokines
such
as
tumor
necrosis
factor
(TNF-α),
interleukin-1β(IL-1β)
interleukin-6(IL-6),
causes
microglia
become
release
mediators,
which
attract
more
damaged
area,
increasing
response.
Moreover,
dysfunction
barrier,
allows
factors
invade
brain
further,
enhances
activation
forming
vicious
circle
intensifies
neuroinflammation.
And
collectively
promote
neuroinflammatory
environment
neurodegeneration
changes
Overall,
findings
deepen
our
complexity
provide
targets
for
strategies
focused
inflammation
regulation
mechanisms.
In
summary,
review
provided
theoretical
basis
clarifying
pathogenesis
summarized
association
systems,
then
emphasized
their
potential
specific
achieving
further
aggravating
Язык: Английский
Effect of 5-alpha reductase inhibitors in animal models of Parkinson’s disease
Frontiers in Neuroendocrinology,
Год журнала:
2024,
Номер
unknown, С. 101156 - 101156
Опубликована: Сен. 1, 2024
Язык: Английский
Nerve Growth Factor and Brain-Derived Neurotrophic Factor in COVID-19
Biology,
Год журнала:
2024,
Номер
13(11), С. 907 - 907
Опубликована: Ноя. 7, 2024
Neurotrophins
(NTs)
constitute
a
family
of
small
protein
messengers
that
play
fundamental
role
in
both
the
central
and
peripheral
nervous
systems.
In
particular,
nerve
growth
factor
(NGF)
brain-derived
neurotrophic
(BDNF)
subtle
survival,
differentiation,
functioning
neuronal
populations,
as
well
fine
regulation
immune
functions.
The
SARS-CoV-2
infection
was
characterized
by
sequela
symptoms
(serious
respiratory
pathology,
inflammatory
storm,
neurological
discomfort,
up
to
less
serious
flu-like
symptoms),
which
caused,
at
end
2023,
more
than
7
million
deaths
worldwide.
Despite
official
pandemic,
physical
psychological
consequences
are
currently
object
scientific
research,
acute
chronic/long-lasting
(Long-COVID-19).
Given
multifactorial
nature
outcomes
adults
children,
several
studies
have
investigated
potential
involvement
NGF
BDNF
systems
pathology.
This
narrative
review
aims
summarize
most
recent
evidence
on
this
crucial
topic.
Язык: Английский