Causal relationship between thyroid function and multiple sclerosis: A bidirectional Mendelian randomization study DOI Creative Commons
Wenhui Cui, Bin Wang, Keqing Shi

и другие.

Medicine, Год журнала: 2024, Номер 103(37), С. e39709 - e39709

Опубликована: Сен. 13, 2024

An association between thyroid function and multiple sclerosis (MS) has been reported in several observational studies, but the causal relationship them is still unclear. Thus, this study used a bidirectional Mendelian randomization (MR) to investigate associations MS. Bidirectional MR was explore (thyroid-stimulating hormone [TSH], free thyroxine [FT4], hyperthyroidism, hypothyroidism) Genome-wide (GWAS) data of MS were obtained from ThyroidOmics Consortium FinnGen Consortium, respectively. Inverse-variance weighted method (IVW) primary analysis assess causality with Weighted median, MR-Egger regression, mode, simple mode as auxiliary methods. Sensitivity analyses performed using heterogeneity tests, horizontal pleiotropy tests leave-one-out method. There positive TSH (IVW: OR = 1.202, 95% CI: 1.040–1.389, P .013), no strong evidence found for an effect FT4 1.286, 0.990–1.671, .059), hypothyroidism 1.247, 0.961–1.617, .096), hyperthyroidism 0.966, 0.907–1.030, .291) on risk In reverse results, there β −0.009, .184), −0.011, .286), 0.992, 0.944–1.042, .745), 1.026, 0.943–1.117, .549). Cochran’s Q test, intercept MR-PRESSO global Leave-one-out did not observe heterogeneity. conclusion, supported

Язык: Английский

The role of the “gut microbiota-mitochondria” crosstalk in the pathogenesis of multiple sclerosis DOI Creative Commons
Huan Tian,

Dunbing Huang,

Jiaqi Wang

и другие.

Frontiers in Microbiology, Год журнала: 2024, Номер 15

Опубликована: Апрель 29, 2024

Multiple Sclerosis (MS) is a neurologic autoimmune disease whose exact pathophysiologic mechanisms remain to be elucidated. Recent studies have shown that the onset and progression of MS are associated with dysbiosis gut microbiota. Similarly, large body evidence suggests mitochondrial dysfunction may also significant impact on development MS. Endosymbiotic theory has found human mitochondria microbial in origin share similar biological characteristics Therefore, microbiota function crosstalk relevant However, relationship between not fully understood. by synthesizing previous literature, this paper focuses changes metabolite composition possible MS, provide new therapeutic approaches for prevention or reduction based crosstalk.

Язык: Английский

Процитировано

4
Regulation of Postoperative Cognitive Dysfunction by Glutathione Under Various Pathways: A Narrative Review DOI Open Access

Yan He,

Ying Zhang, Qing Liu

и другие.

Journal of Biochemical and Molecular Toxicology, Год журнала: 2025, Номер 39(2)

Опубликована: Фев. 1, 2025

Postoperative cognitive dysfunction (POCD) is a common neurological complication after surgery and general anesthesia, the incidence increases with age. Will have negative impact on patients, family society. At present, neuroinflammation oxidative stress are main recognized mechanisms. Glutathione (GSH) powerful reducing agent may be related to POCD. Using medical search engines such as PubMed, Web of Science, we analyzed articles topics as: POCD, GSH, microglia, astrocyte, oligodendrocyte, ferroptosis, BDNF, Neuroinflammation, stress. The above searched in databases using Boolean operations. We included original articles, reviews other article types books. According reviewed literature, GSH treatment for Specific targeted therapies POCD still sparse, therefore, implementation preventive strategies appears remain optimal attitude. Further research needed better understanding

Язык: Английский

Процитировано

0
Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Boost Functional Performance in an Animal Model of Multiple Sclerosis Through Recruiting Oligodendrocytes and Attenuating Gliosis DOI

S Mohammadhadi Mirab,

Ameneh Omidi,

Masoud Soleimani

и другие.

Stem Cell Reviews and Reports, Год журнала: 2025, Номер unknown

Опубликована: Март 7, 2025

Язык: Английский

Процитировано

0
Advances in the study of artemisinin and its derivatives for the treatment of rheumatic skeletal disorders, autoimmune inflammatory diseases, and autoimmune disorders: a comprehensive review DOI Creative Commons
Zhiyong Long, Xiang Wang, Wei Xiao

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Окт. 25, 2024

Artemisinin and its derivatives are widely recognized as first-line treatments for malaria worldwide. Recent studies have demonstrated that artemisinin-based antimalarial drugs, such artesunate, dihydroartemisinin, artemether, not only possess excellent properties but also exhibit antitumor, antifungal, immunomodulatory effects. Researchers globally synthesized artemisinin like SM735, SM905, SM934, which offer advantages low toxicity, high bioavailability, potential immunosuppressive properties. These compounds induce immunosuppression by inhibiting the activation of pathogenic T cells, suppressing B cell antibody production, enhancing differentiation regulatory cells. This review summarized mechanisms analogs modulate excessive inflammation immune responses in rheumatic skeletal diseases, autoimmune inflammatory disorders, through pathways including TNF, Toll-like receptors, IL-6, RANKL, MAPK, PI3K/AKT/mTOR, JAK/STAT, NRF2/GPX4. Notably, context NF-κB pathway, inhibits expression disrupting upstream cascades and/or directly binding to downregulates multiple downstream genes controlled NF-κB, chemokines their receptors. targets regulate various functions, apoptosis, proliferation, signal transduction, antioxidant responses, ultimately intervening systemic diseases organs kidneys, nervous system, skin, liver, biliary system modulating dysregulation responses. Ongoing multicenter randomized clinical trials investigating effects these on rheumatic, inflammatory, with aim translating promising preclinical data into applications.

Язык: Английский

Процитировано

2
Potential Application of Plant-Derived Compounds in Multiple Sclerosis Management DOI Open Access

Seth Woodfin,

S. S. HALL,

Alexis Ramerth

и другие.

Nutrients, Год журнала: 2024, Номер 16(17), С. 2996 - 2996

Опубликована: Сен. 5, 2024

Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurodegeneration, resulting in significant disability reduced quality of life. Current therapeutic strategies primarily target immune dysregulation, but limitations efficacy tolerability highlight the need for alternative treatments. Plant-derived compounds, including alkaloids, phenylpropanoids, terpenoids, have demonstrated anti-inflammatory effects both preclinical clinical studies. By modulating responses promoting neuroregeneration, these compounds offer potential as novel adjunctive therapies MS. This review provides insights into molecular cellular basis MS pathogenesis, emphasizing role inflammation disease progression. It critically evaluates emerging evidence supporting use plant-derived to attenuate symptomology. In addition, we provide comprehensive source information detailing known mechanisms action assessing context with focus on their neuroprotective properties.

Язык: Английский

Процитировано

1
Immunoglobulin G and Complement as Major Players in the Neurodegeneration of Multiple Sclerosis DOI Creative Commons
Peter G. E. Kennedy,

M J Fultz,

Jeremiah Phares

и другие.

Biomolecules, Год журнала: 2024, Номер 14(10), С. 1210 - 1210

Опубликована: Сен. 26, 2024

Multiple Sclerosis (MS) is an inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS) termed as one most common causes neurological disability in young adults. Axonal loss neuronal cell damage are primary progression disability. Yet, little known about mechanism neurodegeneration disease, a limitation that impairs development more effective treatments for progressive MS. MS characterized by presence oligoclonal bands raised levels immunoglobulins CNS. The role complement demyelinating process has been detected both experimental animal models within CNS affected patients. Furthermore, IgG antibodies activation can be plaques cortical gray matter lesions. We propose here play active hypothesize increased form aggregates bind C1q with high affinity, activating classical pathway. This results damage, which leads to demyelination

Язык: Английский

Процитировано

1
Causal relationship between thyroid function and multiple sclerosis: A bidirectional Mendelian randomization study DOI Creative Commons
Wenhui Cui, Bin Wang, Keqing Shi

и другие.

Medicine, Год журнала: 2024, Номер 103(37), С. e39709 - e39709

Опубликована: Сен. 13, 2024

An association between thyroid function and multiple sclerosis (MS) has been reported in several observational studies, but the causal relationship them is still unclear. Thus, this study used a bidirectional Mendelian randomization (MR) to investigate associations MS. Bidirectional MR was explore (thyroid-stimulating hormone [TSH], free thyroxine [FT4], hyperthyroidism, hypothyroidism) Genome-wide (GWAS) data of MS were obtained from ThyroidOmics Consortium FinnGen Consortium, respectively. Inverse-variance weighted method (IVW) primary analysis assess causality with Weighted median, MR-Egger regression, mode, simple mode as auxiliary methods. Sensitivity analyses performed using heterogeneity tests, horizontal pleiotropy tests leave-one-out method. There positive TSH (IVW: OR = 1.202, 95% CI: 1.040–1.389, P .013), no strong evidence found for an effect FT4 1.286, 0.990–1.671, .059), hypothyroidism 1.247, 0.961–1.617, .096), hyperthyroidism 0.966, 0.907–1.030, .291) on risk In reverse results, there β −0.009, .184), −0.011, .286), 0.992, 0.944–1.042, .745), 1.026, 0.943–1.117, .549). Cochran’s Q test, intercept MR-PRESSO global Leave-one-out did not observe heterogeneity. conclusion, supported

Язык: Английский

Процитировано

0