Campylobacter jejuni virulence factors: update on emerging issues and trends
Journal of Biomedical Science,
Год журнала:
2024,
Номер
31(1)
Опубликована: Май 1, 2024
Abstract
Campylobacter
jejuni
is
a
very
common
cause
of
gastroenteritis,
and
frequently
transmitted
to
humans
through
contaminated
food
products
or
water.
Importantly,
C.
infections
have
range
short-
long-term
sequelae
such
as
irritable
bowel
syndrome
Guillain
Barre
syndrome.
triggers
disease
by
employing
molecular
strategies
which
enable
it
colonise
the
gut,
invade
epithelium,
persist
intracellularly
avoid
detection
host
immune
response.
The
objective
this
review
explore
summarise
recent
advances
in
understanding
factors
involved
colonisation,
invasion
cells,
collective
quorum
sensing-mediated
behaviours
persistence.
Understanding
mechanisms
that
underpin
pathogenicity
will
future
development
effective
preventative
approaches
vaccines
against
pathogen.
Язык: Английский
Role of E-cadherin in epithelial barrier dysfunction: implications for bacterial infection, inflammation, and disease pathogenesis
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2025,
Номер
15
Опубликована: Фев. 11, 2025
Epithelial
barriers
serve
as
critical
defense
lines
against
microbial
infiltration
and
maintain
tissue
homeostasis.
E-cadherin,
an
essential
component
of
adherens
junctions,
has
emerged
a
pivotal
molecule
that
secures
epithelial
Lately,
its
pleiotropic
role
beyond
barrier
function,
including
involvement
in
immune
responses,
become
more
evident.
Herein,
we
delve
into
the
intricate
relationship
between
(dys)regulation
homeostasis
versatile
functionality
describing
complex
mechanisms
underlie
integrity
disruption
disease
pathogenesis
such
bacterial
infection
inflammation,
among
others.
Clinical
implications
E-cadherin
perturbations
host
pathophysiology
are
emphasized;
downregulation,
proteolytic
phenomena,
abnormal
localization/signaling
aberrant
reactions
linked
with
broad
spectrum
pathology
infectious
diseases.
Finally,
potential
therapeutic
interventions
may
harness
to
mitigate
barrier-associated
damage
explored.
Overall,
this
review
highlights
crucial
systemic
health,
offering
insights
could
pave
way
for
strategies
reinforce/restore
treat
related
Язык: Английский
Outer membrane vesicles in gram-negative bacteria and its correlation with pathogenesis
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 1, 2025
There
is
a
widespread
distribution
of
gram-negative
bacteria
worldwide,
which
are
responsible
for
the
deaths
numerous
patients
each
year.
The
illnesses
they
cause
can
be
localized
and
systemic,
these
possess
several
key
virulence
factors
that
contribute
to
their
pathogenicity.
In
recent
years,
distinct
mechanisms
pathogenesis
have
evolved
remain
largely
unknown
scientists
medical
experts.
Among
these,
outer
membrane
vesicles
(OMVs)
undoubtedly
one
most
significant
influencing
virulence.
OMVs
contain
various
bacterial
compounds
diverse
effects
on
host
organisms
immune
system,
potentially
exacerbating
disease
inflammation
while
evading
responses.
This
review
comprehensively
examines
role
in
pathogenesis,
interaction
with
cells,
potential
biomedical
applications.
Understanding
molecular
governing
OMV
biogenesis
function
could
pave
way
novel
antimicrobial
strategies
therapeutic
interventions.
Язык: Английский
Exploring the Contribution of Campylobacter jejuni to Post-Infectious Irritable Bowel Syndrome: A Literature Review
Applied Sciences,
Год журнала:
2024,
Номер
14(8), С. 3373 - 3373
Опубликована: Апрель 17, 2024
This
comprehensive
review
investigates
the
specific
impact
of
foodborne
pathogen
Campylobacter
jejuni
(C.
jejuni)
on
gastrointestinal
health,
focusing
its
connection
to
post-infectious
irritable
bowel
syndrome
(PI-IBS).
examines
pathogen’s
pathophysiology,
clinical
implications
and
epidemiological
trends
using
recent
research
data
highlight
prevalence
association
with
PI-IBS.
A
detailed
literature
analysis
synthesizes
current
illuminate
Campylobacter’s
long-lasting
effects
gut
microbiota
intestinal
function.
It
provides
a
shed
light
C.
jejuni’s
long-term
The
findings
suggest
need
for
multifaceted
prevention
treatment
approaches
considering
individual,
microbial
factors,
thus
contributing
more
nuanced
understanding
PI-IBS
following
infection.
Язык: Английский
Immune Responses Elicited by Outer Membrane Vesicles of Gram-Negative Bacteria: Important Players in Vaccine Development
Life,
Год журнала:
2024,
Номер
14(12), С. 1584 - 1584
Опубликована: Дек. 2, 2024
The
attractiveness
of
OMVs
derived
from
Gram-negative
bacteria
lies
in
the
fact
that
they
have
two
biomembranes
sandwiching
a
peptidoglycan
layer.
It
is
well
known
envelope
consists
outer
bacterial
membrane
[OM]
and
not
inner
one
[IM]
source
bacterium.
This
implies
all
membranous
molecules
found
OM
act
as
antigens.
However,
under
specific
conditions,
some
proteins
can
be
exported
into
layer
perform
A
key
information
was
used
purification
procedures
for
OMVs,
induction
methods
to
increase
production
mutant
strains
obtained
via
genetic
engineering
affect
composition
potential
antigens
on
surface
lumen
OMVs.
available
literature
allowed
us
list
major
could
defined
functions
within
bacterium
are
discussed
better
understanding
various
hypotheses
biogenesis
vesicle
formation.
Also,
impacts
OMV
immune
system
using
animal
models
assessed.
Furthermore,
pathways
entering
host
cell
presented.
An
example
infection
causes
epidemic
diseases,
namely
Neisseria
meningitidis,
demonstrate
this
pathogen
elicit
protective
responses
when
administered
vaccine.
vaccines
development
assembled
knowledge
formulate
number
reasons
why
attractive
vaccine
platforms,
their
undesirable
side
effects
remain
small,
provide
an
outlook
use
platform.
Язык: Английский
Therapeutic potential of probiotics to counter Campylobacter infections: An In vitro and In vivo evaluation in mice
Food Bioscience,
Год журнала:
2024,
Номер
60, С. 104383 - 104383
Опубликована: Май 22, 2024
Язык: Английский
Investigating the role of a Tannerella forsythia HtrA protease in host protein degradation and inflammatory response
Frontiers in Oral Health,
Год журнала:
2024,
Номер
5
Опубликована: Июль 5, 2024
Introduction
Degradation
of
host
proteins
by
bacterial
proteases
leads
to
the
subversion
response
and
disruption
oral
epithelial
integrity,
which
is
considered
an
essential
factor
in
progression
periodontitis.
High-temperature
requirement
A
(HtrA)
protease,
critical
for
survival
environmental
adaptation,
found
several
bacteria,
including
periodontal
pathogen
Tannerella
forsythia
.
This
study
investigated
proteolytic
activity
HtrA
from
T.
its
ability
modulate
response.
Methods
was
identified
bioinformatically
produced
as
a
recombinant
protein.
mutants
with
depleted
restored
production
were
constructed.
The
effect
wild-type,
on
degradation
casein
E-cadherin
tested
vitro
Additionally,
responses
human
gingival
fibroblasts
U937
macrophages
different
HtrA-stimuli
compared
those
triggered
HtrA-deficient
mutant.
Results
wild-type
producing
well
enzyme
exhibited
towards
E-cadherin.
No
cytotoxic
either
or
rHtrA
viability
cells
found.
In
hGFB
macrophages,
both
species
induced
inflammatory
similar
magnitude,
indicated
gene
protein
expression
interleukin
(IL)-1β,
IL-6,
IL-8,
tumour
necrosis
α
monocyte
chemoattractant
(MCP)-1.
Recombinant
had
no
significant
hGFBs,
whereas
it
transient
at
early
stage
infection.
Conclusion
exhibit
adhesion
molecule
has
potential
influence
Its
role
periodontitis
needs
further
clarification.
Язык: Английский
Pathogenicity and virulence of Campylobacter jejuni : What do we really know?
Virulence,
Год журнала:
2024,
Номер
15(1)
Опубликована: Дек. 8, 2024
Campylobacter
jejuni
is
the
leading
cause
of
bacterial
gastroenteritis
and
a
major
public
health
concern
worldwide.
Despite
its
importance,
our
understanding
how
C.
causes
diarrhoea
interacts
with
hosts
limited
due
to
absence
appropriate
infection
models
established
virulence
factors
found
in
other
enteric
pathogens.
Additionally,
despite
genetic
diversity,
non-pathogenic
strains
are
unknown.
Regardless
these
limitations,
significant
progress
has
been
made
uses
complex
array
which
aid
bacterium
survive
respond
host
defences.
This
review
provides
an
update
on
fitness
determinants
this
important
pathogen
questions
knowledge
that
often
based
inferred
genomics
surrogate
models.
Язык: Английский