Exosomes as drug delivery systems in glioma immunotherapy
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июнь 18, 2024
Abstract
Recently,
the
significant
benefits
of
cancer
immunotherapy
for
most
cancers
have
been
demonstrated
in
clinical
and
preclinical
studies.
However,
efficacy
these
immunotherapies
gliomas
is
limited,
owing
to
restricted
drug
delivery
insufficient
immune
activation.
As
carriers,
exosomes
offer
advantages
low
toxicity,
good
biocompatibility,
intrinsic
cell
targeting,
which
could
enhance
glioma
efficacy.
a
review
exosome-based
systems
has
not
presented.
This
introduces
current
problems
role
addressing
issues.
Meanwhile,
preparation
application
strategies
are
discussed,
especially
enhancing
immunogenicity
reversing
immunosuppressive
tumor
microenvironment.
Finally,
we
briefly
describe
challenges
translation.
We
anticipate
that
this
will
guide
use
as
carriers
immunotherapy.
Graphical
Язык: Английский
Photodynamic and Sonodynamic Therapy Synergy: Mechanistic Insights and Cellular Responses Against Glioblastoma Multiforme
Journal of drug targeting,
Год журнала:
2024,
Номер
unknown, С. 1 - 23
Опубликована: Ноя. 18, 2024
Glioblastoma
multiforme
(GBM),
the
most
aggressive
form
of
brain
cancer,
poses
substantial
challenges
to
effective
treatment
due
its
complex
and
infiltrative
nature,
making
it
difficult
manage.
Photodynamic
therapy
(PDT)
sonodynamic
(SDT),
have
emerged
as
promising
individual
options
against
GBM
their
least-invasive
approach.
However,
both
PDT
SDT
drawbacks
that
require
careful
consideration.
A
combination
using
light
sound
waves
has
gained
attention,
offering
new
avenues
overcome
from
therapies.
Sono-photodynamic
(SPDT)
been
used
various
tumors.
Researchers
are
considering
SPDT
a
favorable
alternative
conventional
therapies
for
GBM.
offers
complementary
mechanisms
action,
including
production
ROS,
disruption
cellular
structures,
induction
apoptosis,
leading
enhanced
tumor
cell
death.
This
review
gives
an
insight
about
PDT/SDT
limitations
in
need
therapy.
We
try
unveil
process
explore
mechanism
behind
improved
SPDT-meditated
death
cells
by
focusing
on
ROS-mediated
response
occurring
result
discussing
current
modifications
existing
sensitizers
optimal
use
Язык: Английский
MSC-derived extracellular vesicles: Precision miRNA delivery for overcoming cancer therapy resistance
Regenerative Therapy,
Год журнала:
2025,
Номер
29, С. 303 - 318
Опубликована: Апрель 5, 2025
Язык: Английский
Investigating Expression Dynamics of miR-21 and miR-10b in Glioblastoma Cells In Vitro: Insights into Responses to Hypoxia and Secretion Mechanisms
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(14), С. 7984 - 7984
Опубликована: Июль 22, 2024
Glioblastoma
poses
significant
challenges
in
oncology,
with
bevacizumab
showing
promise
as
an
antiangiogenic
treatment
but
limited
efficacy.
microRNAs
(miRNAs)
10b
and
21
have
emerged
potential
biomarkers
for
response
glioblastoma
patients.
This
study
delves
into
the
expression
dynamics
of
miR-21
miR-10b
to
hypoxia
explores
their
circulation
mechanisms.
In
vitro
experiments
exposed
glioma
cells
(A172,
U87MG,
U251)
human
umbilical
vein
endothelial
(HUVEC)
hypoxic
conditions
(1%
oxygen)
24
h,
revealing
heightened
levels
cells.
Manipulating
demonstrating
a
decrease
VEGF
alpha
(VEGFA)
following
overexpression
under
conditions.
Size
exclusion
chromatography
illustrated
notable
shift
towards
exosomal
packaging
during
hypoxia.
A
proposed
model
suggests
that
effective
reduces
VEGFA
levels,
heightening
subsequently
upregulating
expression.
These
miRNAs,
released
via
exosomes,
might
impact
various
cellular
processes,
notably
contributing
level
reduction.
However,
post-treatment
increases
could
potentially
restore
normoxic
through
downregulation
VEGF.
highlights
intricate
feedback
loop
involving
miR-10b,
miR-21,
treatment,
underscoring
necessity
personalized
therapeutic
strategies.
Further
research
should
explore
clinical
implications
treatments.
Язык: Английский
Dormancy and awakening of cancer cells: the extracellular vesicle-mediated cross-talk between Dr. Jekill and Mr. Hyde
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Сен. 5, 2024
Cancer
cell
dormancy
is
a
reversible
process
whereby
cancer
cells
enter
quiescent
state
characterized
by
cycle
arrest,
inhibition
of
migration
and
invasion,
increased
chemoresistance.
Because
its
reversibility
resistance
to
treatment,
key
study,
monitor,
interfere
with,
in
order
prevent
tumor
recurrence
metastasis
improve
the
prognosis
patients.
However,
achieve
this
goal,
further
studies
are
needed
elucidate
mechanisms
underlying
complex
dynamic
dual
process.
Here,
we
review
contribution
extracellular
vesicles
(EVs)
regulation
dormancy/awakening,
focusing
on
cross-talk
between
non-tumor
both
primary
(pre-)metastatic
niche.
Although
EVs
recognized
as
players
progression
metastasis,
well
diagnostics
therapeutics,
their
role
specifically
induction/escape
still
largely
elusive.
We
report
most
recent
promising
results
topic,
EV-associated
nucleic
acids
involved.
highlight
how
EV
could
greatly
contribute
identification
signaling
pathways
dormancy/early
awakening
signature
for
development
successful
diagnostic/prognostic
therapeutic
approaches.
Язык: Английский
Implications of glioblastoma-derived exosomes in modifying the immune system: state-of-the-art and challenges
Reviews in the Neurosciences,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 12, 2024
Glioblastoma
is
a
brain
cancer
with
poor
prognosis.
Failure
of
classical
chemotherapy
and
surgical
treatments
indicates
that
new
therapeutic
approaches
are
needed.
Among
cell-free
options,
exosomes
versatile
extracellular
vesicles
(EVs)
carry
important
cargo
across
barriers
such
as
the
blood-brain
barrier
(BBB)
to
their
target
cells.
This
makes
an
interesting
option
for
treatment
glioblastoma.
Moreover,
can
comprise
many
cargos,
including
lipids,
proteins,
nucleic
acids,
sampled
from
special
intercellular
compartments
origin
cell.
Cells
exposed
various
immunomodulatory
stimuli
generate
enriched
in
specific
molecules.
Notably,
secretion
could
modify
immune
response
innate
adaptive
systems.
For
instance,
glioblastoma-associated
(GBex)
uptake
by
macrophages
influence
macrophage
dynamics
(e.g.,
shifting
CD
markers
expression).
Expression
critical
immunoregulatory
proteins
cytotoxic
T-lymphocyte
antigen-1
(CTLA1)
programmed
death-1
(PD-1)
on
GBex
direct
crosstalk
these
nano-size
system.
The
present
study
reviews
role
system
cells,
B
T
natural
killer
(NK)
dendritic
cells
(DCs),
well
novel
technologies
field.
Язык: Английский
Glioma Stem Cells: GPRC5A as a Novel Predictive Biomarker and Therapeutic Target Associated with Mesenchymal and Stemness Features
Applied Sciences,
Год журнала:
2024,
Номер
14(18), С. 8482 - 8482
Опубликована: Сен. 20, 2024
Glioblastoma
multiforme
(GBM)
represents
the
deadliest
form
of
brain
cancer,
characterized
by
complex
interactions
within
its
microenvironment.
Despite
understanding
GBM
biology,
remains
highly
resistant
to
any
therapy.
Therefore,
defining
innovative
biomarkers
in
can
provide
insights
into
tumor
biology
and
potential
therapeutic
targets.
In
this
study,
we
explored
GPRC5A
serve
as
a
pertinent
biomarker
for
GBM.
We
utilized
GBM-TCGA
dataset
presented
reproducible
bioinformatics
analysis
our
results.
identified
that
expression
was
significantly
upregulated
compared
normal
tissues,
with
higher
levels
correlating
poor
overall
survival
(OS)
progression-free
interval
(PFI).
Moreover,
it
associated
key
genetic
mutations,
particularly
NF1
PTEN
strongly
correlated
mesenchymal
stem-like
phenotype.
also
predominantly
aggressive
features,
including
hypoxia,
high
extracellular
matrix
(ECM)
environments,
extensive
stromal
immune
infiltrations.
Its
strong
correlation
markers
hypoxic
regions
underscores
target
These
findings
valuable
role
pathology
impact
stratifications
treatment
strategies.
Язык: Английский