A review on dynamic pharmacological potency and multifaceted biological activities of propolis
Discover Sustainability,
Год журнала:
2024,
Номер
5(1)
Опубликована: Авг. 8, 2024
Abstract
This
review
explores
the
therapeutic
potential
of
propolis,
a
natural
resin
produced
by
bees,
analyzing
recent
literature
spanning
from
2005
to
2023.
Various
databases
including
Google
Scholar,
Web
Science,
Science
Direct,
PubMed,
SCOPUS,
and
WoS
were
searched
uncover
findings.
Propolis
exhibits
diverse
array
pharmacological
properties,
antimicrobial,
anti-inflammatory,
antioxidant,
immunomodulatory,
wound-healing
effects.
It
shows
promise
in
treating
respiratory
infections,
oral
diseases,
gastrointestinal
disorders,
skin
conditions.
Additionally,
research
suggests
its
as
an
anticancer
agent.
The
also
investigates
efficacy
propolis
addressing
antiviral,
antibacterial,
metabolic
disorders
(diabetes),
reproductive
disorder
(PCOS),
cardiovascular
hepatotoxicity,
wound
healing
properties
propolis.
Hence,
could
emerge
remedy
with
significant
for
enhancing
healthcare
outcomes.
Язык: Английский
Hepatoprotective effects of propolis ethanol extract on D-galactose-induced aging mice: A metabolomics and transcriptomics analysis focusing on insulin resistance pathways
Journal of Functional Foods,
Год журнала:
2025,
Номер
125, С. 106668 - 106668
Опубликована: Янв. 9, 2025
Язык: Английский
Recent developments and innovative application of propolis in the food industry: a natural preservative from honeybee waste
Nalla Bhanu Prakash Reddy,
C. P. Indumathi,
Shweta Deotale
и другие.
Food Science and Biotechnology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 19, 2025
Язык: Английский
Propolis supplementation modulates gut microbiota in rodent models: a systematic review
Nutrire,
Год журнала:
2025,
Номер
50(1)
Опубликована: Фев. 11, 2025
Язык: Английский
Nature’s Remedies: Exploring the Potential of Propolis to Alleviate Non-Motor Manifestations of Parkinson’s Disease
Molecules,
Год журнала:
2025,
Номер
30(8), С. 1672 - 1672
Опубликована: Апрель 8, 2025
Parkinson’s
disease
(PD)
is
a
complex
neurodegenerative
disorder
with
debilitating
non-motor
symptoms,
including
gastrointestinal
dysfunction,
cardiovascular
abnormalities,
mood
and
anxiety
disorders,
cognitive
decline,
sleep
disturbances,
respiratory
pain.
Despite
their
significant
impact
on
quality
of
life,
these
symptoms
are
often
inadequately
addressed.
Propolis
natural
bee-derived
product,
rich
in
bioactive
compounds
anti-inflammatory,
antioxidant,
immunomodulatory,
neuroprotective
properties,
which
holds
potential
PD
due
to
its
multitarget
multipathway
actions,
addressing
various
underlying
mechanisms
symptom
diseases.
Preclinical
clinical
studies
suggest
that
propolis
may
influence
key
pathological
PD’s
symptoms.
Evidence
points
benefits
improving
cognition,
health,
alleviating
sleep-related
issues.
Although
research
remains
scarce,
findings
from
related
conditions
ability
associated
This
review
underscores
the
underexplored
therapeutic
PD,
drawing
existing
evidence
advocating
for
further
fully
assess
role
patient
outcomes.
Язык: Английский
Exceeding the Limits with Nutraceuticals: Looking Towards Parkinson’s Disease and Frailty
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
26(1), С. 122 - 122
Опубликована: Дек. 26, 2024
One
of
the
most
pressing
challenges
facing
society
today
is
rising
prevalence
physical
and
cognitive
frailty.
This
geriatric
condition
makes
older
adults
more
vulnerable
to
disability,
illness,
a
heightened
risk
mortality.
In
this
scenario,
Parkinson’s
disease
(PD)
frailty,
which
share
several
common
characteristics,
are
becoming
increasingly
prevalent
worldwide,
underscoring
urgent
need
for
innovative
strategies.
Nutraceuticals
naturally
occurring
bioactive
compounds
contained
in
foods,
offering
health
benefits
over
above
essential
nutrition.
By
examining
literature
from
past
decade,
review
highlights
how
nutraceuticals
can
act
as
complementary
therapies,
addressing
key
processes,
such
oxidative
stress,
inflammation,
neuroprotection.
Notably,
antioxidant
action
appears
particularly
beneficial
regard
PD
For
instance,
antioxidant-rich
may
mitigate
damage
linked
levodopa
therapy
PD,
potentially
reducing
side
effects
enhancing
treatment
sustainability.
Similarly,
amplify
activity,
muscle
function,
health,
resilience,
thereby
proposes
holistic
approach
integrating
with
exercise,
pharmacotherapy,
lifestyle
adjustments.
It
promises
transform
management
ARD,
prolong
life,
improve
quality
life
well-being
people.
Язык: Английский
Exploring the Therapeutic Potential of Algerian Propolis: GC/MS Profiling, Protective Inclusion Complex, and In Silico Evaluation Against SARS‐CoV‐2 Main Proteases
Peptide Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 27, 2024
ABSTRACT
Propolis,
a
bee
product,
is
renowned
globally
for
its
diverse
pharmacological
activities
attributed
to
phenolic
compounds,
flavonoids,
and
terpenes.
This
study
aims
identify
the
chemical
compounds
in
Algerian
raw
propolis
evaluate
protective
potential
of
inclusion
complex.
Gas
chromatography–mass
spectrometry
(GC/MS),
differential
scanning
calorimetry
(DSC),
thermogravimetric
analysis
(TGA)
were
used
characterization.
Additionally,
molecular
docking
against
SARS‐COVID‐2
main
proteases
ADMET
profiling
conducted.
The
revealed
α‐pinene
(25.29%–11.04%)
limonene
(22.46%–12.88%)
as
major
components
DSC/TGA
demonstrated
effect
encapsulated
molecules,
with
showing
high
activity
7N5Z,
6LU7,
7E6L,
scores
−5.71,
−5.61,
−5.10
kcal/mol,
respectively.
highlights
constituents
drug
candidates
pandemic.
Язык: Английский
REVEALING THE MULTIFACETED LANDSCAPE OF PROPOLIS RESEARCH (1945-2023): A COMPREHENSIVE ANALYSIS OF DYNAMICITY, SPATIOTEMPORAL TRENDS, AND EMERGING PARADIGMS IN SCHOLARLY DISCOURSE
Uludağ Arıcılık Dergisi,
Год журнала:
2024,
Номер
24(2), С. 417 - 441
Опубликована: Ноя. 6, 2024
Propolis,
a
natural
resinous
substance
produced
by
bees,
has
long
been
known
for
its
potential
health
benefits.
This
study
aims
to
present
comprehensive
bibliometric
investigation,
exploring
the
dynamicity,
spatiotemporal
trends,
and
emerging
patterns
in
scholarly
discourse
surrounding
propolis
research.
The
tailed
PRISMA
guidelines
used
MeSH
databases
Scopus
retrieve
relevant
bibliographic
data
spanning
75
years.
R-based
Bibliometrix
VOSviewer
applications
were
employed
analysis.
A
noticeable
increase
production
was
observed
last
two
decades.
Active
participation
research
identified
from
Brazil,
China,
Türkiye.
multidimensional
nature
of
evident
through
diversity
topics
covered
highly
impactful
intellectual
maps
information
sources.
Thematic
evolution
highlighted
dynamic
research,
with
areas
investigation
an
enhanced
understanding
therapeutic
applications.
Five
prominent
themes
emerged:
"propolis,"
"oxidative
stress,"
"honey,"
"beeswax,"
"allergic
contact
dermatitis."
Additionally,
included
chronic
kidney
disease,
COVID-19,
metabolomics.
Mapping
international
cooperation
co-citation
authors
demonstrated
multiple
activities.
findings
this
hold
implications
researchers,
healthcare
professionals,
policymakers,
providing
insights
into
current
landscape
Язык: Английский
The effects of inhibiting IRE1α on the proliferation of ovarian granulosa cells
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 21, 2024
Abstract
IRE1α,
a
type
I
transmembrane
protein
characterized
by
cytoplasmic
serine/threonine
kinase
domain,
is
related
to
ER
stress
and
function
maintenance.
In
this
study,
4µ8c,
highly
effective
selective
inhibitor
of
IRE1α
RNase,
APY29,
an
ATP
competitive
inhibitor,
inhibiting
autophosphorylation
the
were
employed
elucidate
on
proliferation
ovarian
granulosa
cells,
with
ultimate
goal
identifying
novel
strategies
methodologies
for
prevention
treatment
associated
diseases.
Human
cells
(SVOG)
cultured
in
vitro
treated
inhibitors
4µ8c
APY29.
It
was
shown
that
inhibition
reduced
cell
ability
dealing
misfolded
protein,
triggered
oxidative
stress,
altered
mitochondrial
membrane
potential,
inflicted
DNA
damage,
eventually
lead
apoptosis.
Язык: Английский