A novel and high-performance tumor inhibitor of La, N co-doped carbon dots for U251 and LN229 cells
Colloids and Surfaces B Biointerfaces,
Год журнала:
2025,
Номер
249, С. 114520 - 114520
Опубликована: Янв. 14, 2025
Язык: Английский
Molecular Mechanisms and Strategies for Inducing Neuronal Differentiation in Glioblastoma Cells
Zhao-Qi Tang,
Yan-Rong Ye,
Yun Shen
и другие.
Cellular Reprogramming,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 30, 2025
Glioblastoma
multiforme
(GBM)
is
a
highly
invasive
brain
tumor,
and
traditional
treatments
combining
surgery
with
radiochemotherapy
have
limited
effects,
tumor
recurrence
being
almost
inevitable.
Given
the
lack
of
proliferative
capacity
in
neurons,
inducing
terminal
differentiation
GBM
cells
or
glioma
stem
(GSCs)
into
neuron-like
has
emerged
as
promising
strategy.
This
approach
aims
to
suppress
their
proliferation
self-renewal
capabilities
through
differentiation.
review
summarizes
methods
involved
recent
research
on
neuronal
GSCs,
including
regulation
transcription
factors,
signaling
pathways,
miRNA,
use
small
molecule
drugs,
among
various
strategies.
It
also
outlines
interconnections
between
mechanisms
studied,
hoping
provide
ideas
for
exploring
new
therapeutic
avenues
development
differentiation-inducing
drugs
GBM.
Язык: Английский
Synthesis and characterization of activated carbon-supported magnetic nanocomposite (MNPs-OLAC) obtained from okra leaves as a nanocarrier for targeted delivery of morin hydrate
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 9, 2024
Introduction
The
method
of
encapsulating
the
drug
molecule
in
a
carrier,
such
as
magnetic
nanoparticle,
is
promising
development
that
has
potential
to
deliver
medicine
site
where
it
intended
be
administered.
Morin
pentahydroxyflavone
obtained
from
leaves,
stems,
and
fruits
various
plantsmainly
Moraceae
family
exhibiting
diverse
pharmacological
activities
anti-inflammatory,
anti-oxidant,
free
radical
scavenging
helps
treat
diseases
diabetes,
myocardial
infarction
cancer.
Methods
In
this
study,
we
conducted
synthesis
nanocomposite
with
properties
by
coating
biocompatible
activated
carbon
okra
plant
leaves
nanoparticles.
Results
Characterization
synthesized
carbon-coated
was
confirmed
Fourier
transform
infrared,
scanning
electron
microscopy,
dynamic
light
scattering,
zeta
potential.
cytotoxic
effects
drug-loaded
were
examined
HT-29
(Colorectal),
MCF-7
(breast),
U373
(brain),
T98-G
(Glioblastoma)
cancer
cell
lines,
human
umbilical
vein
endothelial
cells
healthy
line.
Discussion
We
studied
loading
release
behavior
morin
hydrate
nanocomposite.
Activated
carriers
can
show
results
for
delivery
drugs
targeted
site.
Язык: Английский
Unraveling the Complexity and Advancements of Transdifferentiation Technologies in the Biomedical Field and Their Potential Clinical Relevance
Archivum Immunologiae et Therapiae Experimentalis,
Год журнала:
2024,
Номер
73(1)
Опубликована: Дек. 5, 2024
Abstract
Chronic
diseases
such
as
cancer,
autoimmunity,
and
organ
failure
currently
depend
on
conventional
pharmaceutical
treatment,
which
may
cause
detrimental
side
effects
in
the
long
term.
In
this
regard,
cell-based
therapy
has
emerged
a
suitable
alternative
for
treating
these
chronic
diseases.
Transdifferentiation
technologies
have
evolved
therapeutic
that
converts
one
differentiated
somatic
cell
into
another
phenotype
by
using
transcription
factors
(TFs),
small
molecules,
or
small,
single-stranded,
non-coding
RNA
molecules
(miRNA).
The
transdifferentiation
techniques
rely
simple,
fast,
standardized,
versatile
protocols
with
minimal
chance
of
tumorigenicity
genotoxicity.
However,
there
are
still
challenges
limitations
need
to
be
addressed
enhance
their
clinical
translation
percentage
near
future.
Taking
account,
we
delineated
features
strategies
used
techniques.
Then,
delved
different
intermediate
states
were
attained
during
transdifferentiation.
Advancements
field
tissue
engineering,
cancer
dissected.
Furthermore,
limitations,
challenges,
future
perspectives
outlined
review
provide
whole
new
picture
molecular
biology,
interdisciplinary
research,
bioinformatics,
artificial
intelligence
will
push
frontiers
technology
further
establish
avenues
biomedical
research.
Язык: Английский