Unraveling the Complexity and Advancements of Transdifferentiation Technologies in the Biomedical Field and Their Potential Clinical Relevance DOI Creative Commons
Purusottam Mishra,

Izabella Biesiada,

Payal Gupta

et al.

Archivum Immunologiae et Therapiae Experimentalis, Journal Year: 2024, Volume and Issue: 73(1)

Published: Dec. 5, 2024

Abstract Chronic diseases such as cancer, autoimmunity, and organ failure currently depend on conventional pharmaceutical treatment, which may cause detrimental side effects in the long term. In this regard, cell-based therapy has emerged a suitable alternative for treating these chronic diseases. Transdifferentiation technologies have evolved therapeutic that converts one differentiated somatic cell into another phenotype by using transcription factors (TFs), small molecules, or small, single-stranded, non-coding RNA molecules (miRNA). The transdifferentiation techniques rely simple, fast, standardized, versatile protocols with minimal chance of tumorigenicity genotoxicity. However, there are still challenges limitations need to be addressed enhance their clinical translation percentage near future. Taking account, we delineated features strategies used techniques. Then, delved different intermediate states were attained during transdifferentiation. Advancements field tissue engineering, cancer dissected. Furthermore, limitations, challenges, future perspectives outlined review provide whole new picture molecular biology, interdisciplinary research, bioinformatics, artificial intelligence will push frontiers technology further establish avenues biomedical research.

Language: Английский

A novel and high-performance tumor inhibitor of La, N co-doped carbon dots for U251 and LN229 cells DOI
Xinyun Ye,

Huanglian Zhong,

Lin Liu

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 249, P. 114520 - 114520

Published: Jan. 14, 2025

Language: Английский

Citations

1
Molecular Mechanisms and Strategies for Inducing Neuronal Differentiation in Glioblastoma Cells DOI

Zhao-Qi Tang,

Yan-Rong Ye,

Yun Shen

et al.

Cellular Reprogramming, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Glioblastoma multiforme (GBM) is a highly invasive brain tumor, and traditional treatments combining surgery with radiochemotherapy have limited effects, tumor recurrence being almost inevitable. Given the lack of proliferative capacity in neurons, inducing terminal differentiation GBM cells or glioma stem (GSCs) into neuron-like has emerged as promising strategy. This approach aims to suppress their proliferation self-renewal capabilities through differentiation. review summarizes methods involved recent research on neuronal GSCs, including regulation transcription factors, signaling pathways, miRNA, use small molecule drugs, among various strategies. It also outlines interconnections between mechanisms studied, hoping provide ideas for exploring new therapeutic avenues development differentiation-inducing drugs GBM.

Language: Английский

Citations

0
Synthesis and characterization of activated carbon-supported magnetic nanocomposite (MNPs-OLAC) obtained from okra leaves as a nanocarrier for targeted delivery of morin hydrate DOI Creative Commons

Cem Öziç,

Erdal Ertaş, Mehmet Fırat Baran

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 9, 2024

Introduction The method of encapsulating the drug molecule in a carrier, such as magnetic nanoparticle, is promising development that has potential to deliver medicine site where it intended be administered. Morin pentahydroxyflavone obtained from leaves, stems, and fruits various plantsmainly Moraceae family exhibiting diverse pharmacological activities anti-inflammatory, anti-oxidant, free radical scavenging helps treat diseases diabetes, myocardial infarction cancer. Methods In this study, we conducted synthesis nanocomposite with properties by coating biocompatible activated carbon okra plant leaves nanoparticles. Results Characterization synthesized carbon-coated was confirmed Fourier transform infrared, scanning electron microscopy, dynamic light scattering, zeta potential. cytotoxic effects drug-loaded were examined HT-29 (Colorectal), MCF-7 (breast), U373 (brain), T98-G (Glioblastoma) cancer cell lines, human umbilical vein endothelial cells healthy line. Discussion We studied loading release behavior morin hydrate nanocomposite. Activated carriers can show results for delivery drugs targeted site.

Language: Английский

Citations

0
Unraveling the Complexity and Advancements of Transdifferentiation Technologies in the Biomedical Field and Their Potential Clinical Relevance DOI Creative Commons
Purusottam Mishra,

Izabella Biesiada,

Payal Gupta

et al.

Archivum Immunologiae et Therapiae Experimentalis, Journal Year: 2024, Volume and Issue: 73(1)

Published: Dec. 5, 2024

Abstract Chronic diseases such as cancer, autoimmunity, and organ failure currently depend on conventional pharmaceutical treatment, which may cause detrimental side effects in the long term. In this regard, cell-based therapy has emerged a suitable alternative for treating these chronic diseases. Transdifferentiation technologies have evolved therapeutic that converts one differentiated somatic cell into another phenotype by using transcription factors (TFs), small molecules, or small, single-stranded, non-coding RNA molecules (miRNA). The transdifferentiation techniques rely simple, fast, standardized, versatile protocols with minimal chance of tumorigenicity genotoxicity. However, there are still challenges limitations need to be addressed enhance their clinical translation percentage near future. Taking account, we delineated features strategies used techniques. Then, delved different intermediate states were attained during transdifferentiation. Advancements field tissue engineering, cancer dissected. Furthermore, limitations, challenges, future perspectives outlined review provide whole new picture molecular biology, interdisciplinary research, bioinformatics, artificial intelligence will push frontiers technology further establish avenues biomedical research.

Language: Английский

Citations

0