Roles of Oxidative Stress and Autophagy in Alcohol-Mediated Brain Damage
Antioxidants,
Год журнала:
2025,
Номер
14(3), С. 302 - 302
Опубликована: Фев. 28, 2025
Excessive
alcohol
consumption
significantly
impacts
human
health,
particularly
the
brain,
due
to
its
susceptibility
oxidative
stress,
which
contributes
neurodegenerative
conditions.
Alcohol
metabolism
in
brain
occurs
primarily
via
catalase,
followed
by
CYP2E1
pathways.
Excess
metabolized
generates
reactive
oxygen/nitrogen
species
(ROS/RNS),
leading
cell
injury
altering
many
different
Elevated
stress
impairs
autophagic
processes,
increasing
post-translational
modifications
and
further
exacerbating
mitochondrial
dysfunction
ER
death.
The
literature
highlights
that
alcohol-induced
disrupts
autophagy
mitophagy,
contributing
neuronal
damage.
Key
mechanisms
include
dysfunction,
epigenetics,
accumulation
of
oxidatively
modified
proteins,
lead
neuroinflammation
impaired
cellular
quality
control.
These
processes
are
exacerbated
chronic
exposure,
resulting
suppression
protective
pathways
like
NRF2-mediated
antioxidant
responses
increased
changes
brain.
Alcohol-mediated
neurotoxicity
involves
complex
interactions
between
metabolism,
regulation,
influenced
various
factors
such
as
drinking
patterns,
nutritional
status,
genetic/environmental
factors,
highlighting
need
for
molecular
studies
unravel
these
develop
targeted
interventions.
Язык: Английский
Identification of ALDH2 as a novel target for the treatment of acute kidney injury in kidney transplantation based on WGCNA and machine learning algorithms and exploration of its potential mechanism of action using animal experiments
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Март 4, 2025
Background
Acute
kidney
injury
(AKI)
after
transplantation
is
one
of
the
main
causes
graft
loss
and
poor
patient
prognosis,
it
important
to
explore
new
targets
for
treating
AKI
in
transplantation.
Methods
Based
on
AKI-related
dataset
GSE30718,
most
relevant
modular
genes
among
them
were
firstly
screened
using
WGCNA
intersected
with
DEGs,
used
as
candidate
AKI.
Second,
machine
learning
algorithms
utilized
identify
key
them,
HPA
database
was
expression
landscape.
Next,
we
constructed
a
rat
renal
IRI
model
explored
role
IRI.
Finally,
combined
ssGSEA
enrichment
analysis
animal
experiments
further
validate
potential
mechanism
action
genes.
Results
In
total,
identified
98
417
which
yield
total
24
by
three
types
learning,
namely,
Random
Forest,
LASSO
regression
SVM,
obtained
1
gene
ALDH2,
Using
database,
found
that
ALDH2
has
high
level
tissues
mainly
located
tubular
epithelial
cells.
increasing
alleviated
impairment
function
decreased
NGAL,
marker
injury,
BAX,
an
apoptotic
protein,
well
reducing
inflammatory
factors
IL1β
IL6.
experiments,
able
inhibit
activation
MAPK
signaling
pathway.
Conclusion
may
serve
novel
target
treatment
AKI,
protective
effect
IRI,
this
be
achieved
inhibiting
Язык: Английский
Unveiling Hidden Threats: Novel Detection of Acetaldehyde Dehydrogenase Inhibitors in Everyday Foods
LWT,
Год журнала:
2025,
Номер
unknown, С. 117768 - 117768
Опубликована: Апрель 1, 2025
Язык: Английский
Transgenic expression of human cytochrome P450 2E1 in C. elegans and rat PC-12 cells sensitizes to ethanol-induced locomotor and mitochondrial effects
Biochemical and Biophysical Research Communications,
Год журнала:
2024,
Номер
734, С. 150735 - 150735
Опубликована: Сен. 24, 2024
Язык: Английский