Roles of Oxidative Stress and Autophagy in Alcohol-Mediated Brain Damage

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 302 - 302

Published: Feb. 28, 2025

Excessive alcohol consumption significantly impacts human health, particularly the brain, due to its susceptibility oxidative stress, which contributes neurodegenerative conditions. Alcohol metabolism in brain occurs primarily via catalase, followed by CYP2E1 pathways. Excess metabolized generates reactive oxygen/nitrogen species (ROS/RNS), leading cell injury altering many different Elevated stress impairs autophagic processes, increasing post-translational modifications and further exacerbating mitochondrial dysfunction ER death. The literature highlights that alcohol-induced disrupts autophagy mitophagy, contributing neuronal damage. Key mechanisms include dysfunction, epigenetics, accumulation of oxidatively modified proteins, lead neuroinflammation impaired cellular quality control. These processes are exacerbated chronic exposure, resulting suppression protective pathways like NRF2-mediated antioxidant responses increased changes brain. Alcohol-mediated neurotoxicity involves complex interactions between metabolism, regulation, influenced various factors such as drinking patterns, nutritional status, genetic/environmental factors, highlighting need for molecular studies unravel these develop targeted interventions.

Language: Английский

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Identification of ALDH2 as a novel target for the treatment of acute kidney injury in kidney transplantation based on WGCNA and machine learning algorithms and exploration of its potential mechanism of action using animal experiments

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 4, 2025

Background Acute kidney injury (AKI) after transplantation is one of the main causes graft loss and poor patient prognosis, it important to explore new targets for treating AKI in transplantation. Methods Based on AKI-related dataset GSE30718, most relevant modular genes among them were firstly screened using WGCNA intersected with DEGs, used as candidate AKI. Second, machine learning algorithms utilized identify key them, HPA database was expression landscape. Next, we constructed a rat renal IRI model explored role IRI. Finally, combined ssGSEA enrichment analysis animal experiments further validate potential mechanism action genes. Results In total, identified 98 417 which yield total 24 by three types learning, namely, Random Forest, LASSO regression SVM, obtained 1 gene ALDH2, Using database, found that ALDH2 has high level tissues mainly located tubular epithelial cells. increasing alleviated impairment function decreased NGAL, marker injury, BAX, an apoptotic protein, well reducing inflammatory factors IL1β IL6. experiments, able inhibit activation MAPK signaling pathway. Conclusion may serve novel target treatment AKI, protective effect IRI, this be achieved inhibiting

Language: Английский

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Unveiling Hidden Threats: Novel Detection of Acetaldehyde Dehydrogenase Inhibitors in Everyday Foods

LWT, Journal Year: 2025, Volume and Issue: unknown, P. 117768 - 117768

Published: April 1, 2025

Language: Английский

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Transgenic expression of human cytochrome P450 2E1 in C. elegans and rat PC-12 cells sensitizes to ethanol-induced locomotor and mitochondrial effects

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 734, P. 150735 - 150735

Published: Sept. 24, 2024

Language: Английский

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