Biomolecules,
Год журнала:
2023,
Номер
13(2), С. 226 - 226
Опубликована: Янв. 24, 2023
Mitochondria
are
widely
considered
the
"power
hub"
of
cell
because
their
pivotal
roles
in
energy
metabolism
and
oxidative
phosphorylation.
However,
beyond
production
ATP,
which
is
major
source
chemical
supply
eukaryotes,
mitochondria
also
central
to
calcium
homeostasis,
reactive
oxygen
species
(ROS)
balance,
apoptosis.
The
perform
crucial
multifaceted
biosynthetic
pathways,
serving
as
an
important
building
blocks
for
biosynthesis
fatty
acid,
cholesterol,
amino
glucose,
heme.
Since
play
multiple
vital
cell,
it
not
surprising
that
disruption
mitochondrial
function
has
been
linked
a
myriad
diseases,
including
neurodegenerative
cancer,
metabolic
disorders.
In
this
review,
we
discuss
key
physiological
pathological
functions
present
bioactive
compounds
with
protective
effects
on
mechanisms
action.
We
highlight
promising
existing
difficulties
limiting
therapeutic
use
these
potential
solutions.
provide
insights
perspectives
into
future
research
windows
modulators.
Abstract
The
m
6
A
RNA
methylation
is
the
most
prevalent
internal
modification
in
mammalian
mRNAs
which
plays
critical
biological
roles
by
regulating
vital
cellular
processes.
Dysregulations
of
due
to
aberrant
expression
its
regulatory
proteins
are
frequently
observed
many
pathological
conditions,
particularly
cancer.
Normal
cells
undergo
malignant
transformation
via
activation
or
modulation
different
oncogenic
signaling
pathways
through
complex
mechanisms.
Accumulating
evidence
showing
regulation
at
epitranscriptomic
level
has
added
an
extra
layer
complexity.
In
particular,
recent
studies
demonstrated
that,
types
cancers
various
modulated
target
as
well
noncoding
transcripts.
modifications
these
molecules
control
their
fate
and
metabolism
stability,
translation
subcellular
localizations.
this
review
we
discussed
exciting
on
that
and/or
regulators
cancer
provided
perspectives
for
further
studies.
also
render
them
potential
druggable
targets
treatment
Cells,
Год журнала:
2023,
Номер
12(12), С. 1671 - 1671
Опубликована: Июнь 20, 2023
The
dysregulated
phosphatidylinositol-3-kinase
(PI3K)-Akt-mammalian
target
of
rapamycin
(mTOR)
signaling
pathway
has
been
implicated
in
various
immune-mediated
inflammatory
and
hyperproliferative
dermatoses
such
as
acne,
atopic
dermatitis,
alopecia,
psoriasis,
wounds,
vitiligo,
is
associated
with
poor
treatment
outcomes.
Improved
comprehension
the
consequences
PI3K/Akt/mTOR
patients
resulted
development
novel
therapeutic
approaches.
Nonetheless,
more
studies
are
necessary
to
validate
regulatory
role
this
create
effective
preventive
methods
for
a
wide
range
skin
diseases.
Several
have
revealed
that
certain
natural
products
synthetic
compounds
can
obstruct
expression/activity
PI3K/Akt/mTOR,
underscoring
their
potential
managing
common
persistent
disorders.
This
review
summarizes
recent
advances
understanding
activated
components
discusses
bioactive
products,
scaffolds,
biologic
agents
prevention
treatment.
However,
further
research
develop
therapies
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(5), С. 2984 - 2984
Опубликована: Март 4, 2024
Melanoma,
a
highly
aggressive
skin
cancer,
is
characterized
by
rapid
progression
and
high
mortality.
Recent
advances
in
molecular
pathogenesis
have
shed
light
on
genetic
epigenetic
changes
that
drive
melanoma
development.
This
review
provides
an
overview
of
these
developments,
focusing
mechanisms
genesis.
It
highlights
how
mutations,
particularly
the
BRAF,
NRAS,
c-KIT,
GNAQ/GNA11
genes,
affect
critical
signaling
pathways.
The
evolution
diagnostic
techniques,
such
as
genomics,
transcriptomics,
liquid
biopsies,
biomarkers
for
early
detection
prognosis,
also
discussed.
therapeutic
landscape
has
transformed
with
targeted
therapies
immunotherapies,
improving
patient
outcomes.
paper
examines
efficacy,
challenges,
prospects
treatments,
including
recent
clinical
trials
emerging
strategies.
potential
novel
treatment
strategies,
neoantigen
vaccines,
adoptive
cell
transfer,
microbiome
interactions,
nanoparticle-based
combination
therapy,
explored.
These
emphasize
challenges
therapy
resistance
importance
personalized
medicine.
underlines
necessity
evidence-based
selection
managing
increasing
global
incidence
melanoma.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
174, С. 116481 - 116481
Опубликована: Март 24, 2024
Sirtuins
(SIRTs)
represent
a
class
of
nicotinamide
adenine
dinucleotide
(NAD+)-dependent
protein
deacetylases
that
exert
crucial
role
in
cellular
signal
transduction
and
various
biological
processes.
The
mammalian
sirtuins
family
encompasses
SIRT1
to
SIRT7,
exhibiting
therapeutic
potential
counteracting
aging,
modulating
metabolism,
responding
oxidative
stress,
inhibiting
tumors,
improving
microenvironment.
These
enzymes
are
intricately
linked
the
occurrence
treatment
diverse
pathological
conditions,
including
cancer,
autoimmune
diseases,
cardiovascular
disorders.
Given
significance
histone
modification
gene
expression
chromatin
structure,
maintaining
equilibrium
is
imperative
for
disease
prevention
health
restoration.
Mounting
evidence
suggests
modulators
SIRTs
play
treating
diseases
physiological
balance.
This
review
delves
into
molecular
structure
regulatory
functions
family,
reviews
classification
historical
evolution
modulators,
offers
systematic
overview
existing
modulation
strategies,
elucidates
mechanisms
(agonists
inhibitors)
their
clinical
applications.
article
concludes
by
summarizing
challenges
encountered
modulator
research
offering
insights
future
directions.
Cells,
Год журнала:
2021,
Номер
10(5), С. 1219 - 1219
Опубликована: Май 17, 2021
The
phosphatidylinositol
3-kinase
(PI3K)/protein
kinase
B
(Akt)
signaling
pathway
regulates
cell
proliferation,
differentiation,
and
migration,
along
with
angiogenesis
metabolism.
Additionally,
it
could
mediate
skin
development
homeostasis.
There
is
much
evidence
to
suggest
that
dysregulation
of
PI3K/Akt
frequently
associated
several
human
cutaneous
malignancies
like
malignant
melanoma
(MM),
basal
carcinoma
(BCC),
squamous
(SCC),
as
well
their
poor
outcomes.
Nevertheless,
emerging
roles
cascade
in
a
group
common
non-malignant
disorders
including
acne
psoriasis,
among
others,
have
been
recognized.
enhanced
understanding
dysfunction
patients
these
has
offered
solid
foundation
for
the
progress
updated
therapeutic
targets.
This
article
reviews
latest
advances
targets
homeostasis
progression
wide
range
describes
current
preclinical
clinical
researches
on
involvement
targeted
therapies.
Experimental and Therapeutic Medicine,
Год журнала:
2021,
Номер
21(5)
Опубликована: Март 23, 2021
Renal
cell
carcinoma
(RCC)
accounts
for
over
90%
of
all
renal
malignancies,
and
mainly
affects
the
male
population.
Obesity
smoking
are
involved
in
pathogenesis
several
systemic
cancers
including
RCC.
The
phosphoinositide
3‑kinase
(PI3K)/protein
kinase
B
(AKT)/mammalian
target
rapamycin
(mTOR)
signalling
pathway
regulates
growth,
differentiation,
migration,
survival,
angiogenesis,
metabolism.
Growth
factors,
hormones,
cytokine
many
extracellular
cues
activate
PI3K/AKT/mTOR.
Dysregulation
this
molecular
is
frequently
reported
human
RCC
associated
with
aggressive
development
poor
survival
rate.
mTOR
master
regulator
metabolism
activated
pathological
processes
such
as
tumour
formation,
insulin
resistance
angiogenesis.
inhibitors
used
at
present
drug
therapy
to
inhibit
proliferation,
cycle.
Temsirolimus
everolimus
two
that
currently
treatment
Drugs
targeting
PI3K/AKT/mTOR
may
be
one
best
therapeutic
options
