Toward Overcoming Treatment Failure in Rheumatoid Arthritis DOI Creative Commons
Zhuqian Wang, Jie Huang, Duoli Xie

и другие.

Frontiers in Immunology, Год журнала: 2021, Номер 12

Опубликована: Дек. 23, 2021

Rheumatoid arthritis (RA) is an autoimmune disorder characterized by inflammation and bone erosion. The exact mechanism of RA still unknown, but various immune cytokines, signaling pathways effector cells are involved. Disease-modifying antirheumatic drugs (DMARDs) commonly used in treatment classified into different categories. Nevertheless, based on a "trial-and-error" approach, substantial proportion patients show failed therapy for each DMARD. Over the past decades, great efforts have been made to overcome failure, including identification biomarkers, exploration reasons loss efficacy, development sequential or combinational DMARDs strategies approval new DMARDs. Here, we summarize these efforts, which would provide valuable insights accurate clinical medication. While gratifying, researchers realize that far from enough recommend specific individual patients. Precision medicine emerging medical model proposes highly individualized tailored approach disease management. In this review, also discuss potential precision overcoming with introduction cutting-edge technologies big data.

Язык: Английский

Targeting epigenetic regulators for inflammation: Mechanisms and intervention therapy DOI Creative Commons
Su Zhang, Yang Meng, Lian Zhou

и другие.

MedComm, Год журнала: 2022, Номер 3(4)

Опубликована: Сен. 15, 2022

Emerging evidence indicates that resolution of inflammation is a critical and dynamic endogenous process for host tissues defending against external invasive pathogens or internal tissue injury. It has long been known autoimmune diseases chronic inflammatory disorders are characterized by dysregulated immune responses, leading to excessive uncontrol inflammation. The dysregulation epigenetic alterations including DNA methylation, posttranslational modifications histone proteins, noncoding RNA expression implicated in the system. response considered as trigger turn intercede actions. Thus, understanding molecular mechanism dictates outcome targeting regulators disease required resolution. In this article, we elucidate role nuclear factor-κB signaling pathway, JAK/STAT NLRP3 inflammasome diseases. And formulate relationship between inflammation, coronavirus 2019, human cancers. Additionally, review involved innate cells. All matters propose discuss rejuvenation potential interventions target regulatory mechanisms inflammation-associated improve therapeutic outcomes.

Язык: Английский

Процитировано

34
New Targets and Strategies for Rheumatoid Arthritis: From Signal Transduction to Epigenetic Aspect DOI Creative Commons
Menglin Zhu, Qian Ding, Zhongxiao Lin

и другие.

Biomolecules, Год журнала: 2023, Номер 13(5), С. 766 - 766

Опубликована: Апрель 28, 2023

Rheumatoid arthritis (RA) is a chronic autoimmune disease that can lead to joint damage and even permanent disability, seriously affecting patients’ quality of life. At present, the complete cure for RA not achievable, only relieve symptoms reduce pain patients. Factors such as environment, genes, sex induce RA. Presently, non-steroidal anti-inflammatory drugs, DRMADs, glucocorticoids are commonly used in treating In recent years, some biological agents have also been applied clinical practice, but most side effects. Therefore, finding new mechanisms targets necessary. This review summarizes potential discovered from perspective epigenetics mechanisms.

Язык: Английский

Процитировано

18
Isorhamnetin Downregulates MMP2 and MMP9 to Inhibit Development of Rheumatoid Arthritis through SRC/ERK/CREB Pathway DOI
Xiaorong Liu,

Shuofu Li,

Wen-ya Mei

и другие.

Chinese Journal of Integrative Medicine, Год журнала: 2024, Номер 30(4), С. 299 - 310

Опубликована: Янв. 12, 2024

Язык: Английский

Процитировано

6
Cell-Free DNA in Rheumatoid Arthritis DOI Open Access
Teppei Hashimoto, Kohsuke Yoshida, Akira Hashiramoto

и другие.

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(16), С. 8941 - 8941

Опубликована: Авг. 19, 2021

Endogenous DNA derived from the nuclei or mitochondria is released into bloodstream following cell damage death. Extracellular DNA, called cell-free (cfDNA), associated with various pathological conditions. Recently, multiple aspects of cfDNA have been assessed, including levels, integrity, methylation, and mutations. Rheumatoid arthritis (RA) most common form autoimmune arthritis, treatment RA has highly varied outcomes. in patients elevated peripheral blood synovial fluid disease activity. Profiling may then be utilized clinical practice, such as prediction prognosis responses; monitoring state; a diagnostic marker. In this review, we discuss RA, particularly sources correlation pathogenesis. We also highlight potential analyzing profiles to guide individualized approaches for RA.

Язык: Английский

Процитировано

40
Fibroblast pathology in inflammatory joint disease DOI
Lucy‐Jayne Marsh, Samuel Kemble,

Patricia Reis Nisa

и другие.

Immunological Reviews, Год журнала: 2021, Номер 302(1), С. 163 - 183

Опубликована: Июнь 6, 2021

Abstract Rheumatoid arthritis is an immune‐mediated inflammatory disease in which fibroblasts contribute to both joint damage and inflammation. Fibroblasts are a major cell constituent of the lining cavity called synovial membrane. Under resting conditions, have important role maintaining homeostasis, producing extracellular matrix lubricants. In contrast, during inflammation, pathology by pathogenic levels mediators that drive recruitment retention cells within joint. Recent advances single‐cell profiling techniques transformed our ability examine fibroblast biology, leading identification specific subsets, defining previously underappreciated heterogeneity disease‐associated populations. These studies challenging held dogma homogeneous providing unique insights into their pathology. this review, we discuss recent understanding how contributes rheumatoid arthritis. Finally, address these could lead development novel therapies directly target selective populations future.

Язык: Английский

Процитировано

39
DNA Methylation: Genomewide Distribution, Regulatory Mechanism and Therapy Target DOI Creative Commons
Daria Kaplun, Dmitry N. Kaluzhny, Egor Prokhortchouk

и другие.

Acta Naturae, Год журнала: 2023, Номер 14(4), С. 4 - 19

Опубликована: Янв. 20, 2023

DNA methylation is the most important epigenetic modification involved in regulation of transcription, imprinting, establishment X-inactivation, and formation a chromatin structure. genome often associated with transcriptional repression closed heterochromatin. However, results genome-wide studies pattern activity genes have nudged us toward reconsidering this paradigm, since promoters many remain active despite their methylation. The differences distribution normal pathological conditions allow to consider as diagnostic marker or therapy target. In regard, need investigate factors affecting those its interpretation becomes pressing. Recently, large number protein been uncovered, whose ability bind depends on Many these proteins act not only activators repressors, but also affect level These are considered potential therapeutic targets for treatment diseases resulting from either change level. addition factors, secondary structure can be review, latest research into landscape has summarized discuss why some regions avoid what and, therefore,

Язык: Английский

Процитировано

14
Efficacy of HDAC inhibitors and epigenetic modulation in the amelioration of synovial inflammation, cellular invasion, and bone erosion in rheumatoid arthritis pathogenesis DOI

M. Vijaykrishnaraj,

Prakash Patil, Sudeep D. Ghate

и другие.

International Immunopharmacology, Год журнала: 2023, Номер 122, С. 110644 - 110644

Опубликована: Июль 14, 2023

Язык: Английский

Процитировано

14
Biomarkers (mRNAs and non-coding RNAs) for the diagnosis and prognosis of rheumatoid arthritis DOI Creative Commons
Yong Jiang, Shuxin Zhong, Shenghua He

и другие.

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Фев. 1, 2023

In recent years, diagnostic and therapeutic approaches for rheumatoid arthritis (RA) have continued to improve. However, in the advanced stages of disease, patients are unable achieve long-term clinical remission often suffer from systemic multi-organ damage severe complications. Patients with RA usually no overt manifestations early stages, by time a definitive diagnosis is made, disease already at an stage. diagnosed clinically laboratory tests, including blood markers C-reactive protein (CRP) erythrocyte sedimentation rate (ESR) autoantibodies factor (RF) anticitrullinated antibodies (ACPA). presence RF ACPA associated aggravated joint damage, increased mortality, these low specificity sensitivity. The etiology unknown, pathogenesis involving multiple factors heterogeneity. diagnosis, subtype classification, prognosis remain challenging, studies develop minimally invasive or non-invasive biomarkers form biofluid biopsies becoming more common. Non-coding RNA (ncRNA) molecules composed long non-coding RNAs, small nucleolar microRNAs, circular which play essential role onset progression can be used RA. this review prognostic we provide overview current knowledge on subject, focusing advances mRNA–ncRNA as tissue level.

Язык: Английский

Процитировано

13
Current trends in epigenetic, cellular and molecular pathways in management of rheumatoid arthritis DOI
Rashita Makkar, Aayush Sehgal, Sukhbir Singh

и другие.

Inflammopharmacology, Год журнала: 2023, Номер 31(4), С. 1577 - 1588

Опубликована: Июнь 19, 2023

Язык: Английский

Процитировано

13
Research on Prediction of Multiple Degenerative Diseases and Biomarker Screening Based on DNA Methylation DOI Open Access
Run Tian, Hao Zhang, Chencai Wang

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(1), С. 313 - 313

Опубликована: Янв. 1, 2025

The aging process will lead to a gradual functional decline in the human body, and even accelerate significantly increased risk of degenerative diseases. DNA methylation patterns change markedly with one’s age, serving as biomarker biological age closely linked occurrence progression age-related Currently, diagnostic methods for individual diseases are relatively mature. However, often accompanies onset multiple diseases, presenting certain limitations existing models. Additionally, some identified biomarkers typically applicable only one or few types cancer further restricting their utility. We endeavor screen associated from perspective aging-related co-morbid mechanisms perform disease diagnoses. In this study, we explored research based on correlations investigate shared across identifying set them. validated these omics analysis prediction classes screened 600 110 by analysis, demonstrated validity predictive ability biomarkers. propose model multi-scale one-dimensional convolutional neural network (MSDCNN) multi-class (ResDegNet). two models well trained tested accurately diagnose categorize four providing foundation exploration conditions. This work aims facilitate early diagnosis, identification biomarkers, development therapeutic targets drug interventions.

Язык: Английский

Процитировано

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