First Report on Microbial-Derived Polydeoxyribonucleotide: A Sustainable and Enhanced Alternative to Salmon-Based Polydeoxyribonucleotide

Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(1), С. 41 - 41

Опубликована: Янв. 9, 2025

Polydeoxyribonucleotide (PDRN) has emerged as a potent bioactive compound with proven efficacy in wound healing, tissue regeneration, and anti-inflammatory applications is predominantly derived from salmonid gonads. However, this study presents groundbreaking advancement by successfully extracting characterizing PDRN microbial sources, specifically Lactobacillus rhamnosus, marking the first report to utilize microbial-, biome-, or Lactobacillus-derived (L-PDRN). The findings demonstrate enhanced biological properties of L-PDRN over traditional salmon-derived across several assays. exhibited superior antioxidant activity, significantly higher SOD-like DPPH radical scavenging activities compared PDRN, particularly at concentrations. In wound-healing assays, demonstrated promoting cell migration closure, even under inflammatory conditions induced tumor necrosis factor (TNF-α). Additionally, potential for immunostimulatory effects non-inflammatory while maintaining lipopolysaccharide (LPS) stimulation. Electrophoretic analysis revealed that consists smaller DNA fragments (under 100 bp) (200–800 bp), suggesting greater bioavailability skin absorption. Mechanistic studies confirmed activates focal adhesion kinase (FAK) protein B (AKT) signaling pathway through A2A receptor, similar also engaging alternative pathways p38 ERK phosphorylation, highlighting its versatility. This underscores multifunctional sustainable offering bioactivity, scalability, environmental benefits. novel approach utilizing microbial-derived opens new avenues therapeutic oxidative stress management, immune modulation, paving way paradigm shift sourcing functionality.

Язык: Английский

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Cosmeceuticals: A Review of Clinical Studies Claiming to Contain Specific, Well-Characterized Strains of Probiotics or Postbiotics

Nutrients, Год журнала: 2024, Номер 16(15), С. 2526 - 2526

Опубликована: Авг. 2, 2024

The skin serves as a critical barrier against external threats—dehydration, ultraviolet exposure, and infections—playing significant role in internal homeostasis moisture retention. Additionally, equally importantly, it interacts dynamically with the complex microbiome resident it, which is essential for maintaining health. Recent interest has focused on use of probiotics postbiotics, besides their ability to modulate microbiome, enhance function, exhibit anti-inflammatory properties, be involved skincare, by having potential improve hydration, elasticity, overall appearance, well reducing signs aging, such wrinkles fine lines. products—being combination cosmetic regime plus probiotic[s] or postbiotic[s]—are named cosmeceuticals. However, comply regulations characterization microorganism specific probiotic strain, pro- postbiotics incorporated into should both genetically phenotypically defined. Thus, this review, we present 14 published clinical trials using products specific, well-characterized strains applied volunteers healthy skin. Looking at results these studies collectively, can say that defined either live inanimate bacteria and/or components seem keep treated least fully hydrated, intact epithelial tone, increased radiance, decreased wrinkle depth, while normalizing commensal microbiota. Future advancements personalized care may lead genomic sequencing metabolomics tailor postbiotic treatments individual microbiomes, promising new frontier

Язык: Английский

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Oral Yak Whey Protein Can Alleviate UV-Induced Skin Photoaging and Modulate Gut Microbiota Composition

Foods, Год журнала: 2024, Номер 13(16), С. 2621 - 2621

Опубликована: Авг. 21, 2024

Excessive UV exposure can lead to skin roughness, wrinkles, pigmentation, and reduced elasticity, with severe cases potentially causing cancer. Nowadays, various anti-photoaging strategies have been developed maintain health. Among them, dietary supplements properties are gaining increasing attention. Yak whey protein (YWP) possesses multiple benefits, including anti-inflammatory, antioxidant, immune-boosting properties, effectively protecting the skin. This study used a mixed UVA UVB light source irradiate nude mouse model, exploring advantages of YWP in regulating gut microbiota. The results indicated that alleviated UV-induced damage, dryness, elasticity by inhibiting oxidative stress, inflammatory factors (IL-1α, IL-6, TNF-α), matrix metalloproteinases (MMP-1, MMP-3, MMP-12), thereby levels elastin, type I collagen, III collagen extracellular (ECM). Additionally, significantly improved abundance Firmicutes Bacteroidota microbiota mice, promoting growth beneficial bacteria such as Lachnospiraceae_NK4A136_group, Ruminococcus_torques_group, Clostridia_UCG_014, mitigating dysbiosis caused photoaging. These findings underscore potential improvement, highlighting it promising functional food for enhancing

Язык: Английский

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Decoding the impact of ageing and environment stressors on skin cell communication

Biogerontology, Год журнала: 2024, Номер 26(1)

Опубликована: Окт. 29, 2024

Язык: Английский

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