Editorial for Special Issue: “Molecular Mechanisms Underlying Fatty Liver Disease: From Pathogenesis to Treatment”

Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(3), С. 160 - 160

Опубликована: Фев. 27, 2025

Metabolic-dysfunction-associated fatty liver disease (MAFLD) and alcohol-associated (ALD) represent two of the most prevalent chronic diseases globally, collectively affecting hundreds millions individuals [...]

Язык: Английский

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Review of the mechanisms of the biliary-enteric axis in the development of cholangiocarcinoma

World Journal of Clinical Oncology, Год журнала: 2025, Номер 16(4)

Опубликована: Март 26, 2025

Cholangiocarcinoma (CCA) is a particularly aggressive and challenging type of cancer, known for its poor prognosis, which worsened by the complex interplay various biological environmental factors that contribute to development. Recently, researchers have increasingly focused on significant role biliary-enteric communication liver-gut axis in pathogenesis CCA, highlighting relationship has not been thoroughly explored before. This review aims summarize key concepts related investigate potential mechanisms may lead onset progression disease presents substantial treatment challenges. Important areas focus will include microbiome's profound influence, interacts with host physiology ways worsen cancer development; changes bile acid metabolism can create toxic environments favorable tumor growth; regulation inflammatory processes either promote or inhibit progression; immune system's involvement, crucial body's response cancer; interactions within metabolic pathways affect cellular behavior dynamics. By integrating recent research findings from studies, we aim explore multifaceted roles providing new insights perspectives future while identifying promising therapeutic targets could innovative strategies aimed at improving patient outcomes this disease.

Язык: Английский

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Probiotics may be useful for drug-induced liver dysfunction in patients with depression – A secondary analysis of a randomized clinical trial

Clinical Nutrition ESPEN, Год журнала: 2024, Номер 63, С. 604 - 614

Опубликована: Июль 30, 2024

There is a need to identify new treatment options for depression with its comorbidities. Depression often coexists liver steatosis and the two may share pathophysiological overlap, including inflammation microbiota changes. Probiotics might represent safe option as an adjunctive therapy in patients possible steatosis. The paper presents secondary analysis of clinical trial effect probiotic supplementation on levels non-invasive markers fibrosis adult depressive disorders.

Язык: Английский

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Alleviation of Alcoholic Liver Injury through Composite Postbiotics Regulation of Intestinal Flora and Promotion of Bile Acid Metabolism

Food Bioscience, Год журнала: 2024, Номер unknown, С. 105379 - 105379

Опубликована: Окт. 1, 2024

Язык: Английский

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Diammonium glycyrrhizinate alleviates iron overload-induced liver injury in mice via regulating the gut-liver axis

Phytomedicine, Год журнала: 2024, Номер 135, С. 156216 - 156216

Опубликована: Ноя. 8, 2024

Язык: Английский

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