Diagnostics,
Год журнала:
2024,
Номер
14(24), С. 2789 - 2789
Опубликована: Дек. 12, 2024
Background/Objectives:
Beta-thalassemia
(BTH),
a
genetic
disorder
resulting
from
beta-globin
gene
mutations,
affects
over
1.5
million
people
globally.
The
disorder’s
multifactorial
impact
on
male
fertility,
particularly
through
oxidative
stress
(OS),
warrants
focused
study.
This
review
examines
the
mechanisms
of
OS
in
TM,
its
implications
for
infertility,
and
potential
antioxidant
therapies
to
mitigate
fertility
challenges.
Methods:
A
non-systematic
was
conducted
using
PubMed,
Cochrane,
Medscape
databases,
focusing
studies
beta-thalassemia
erectile
dysfunction
(ED),
hormonal
alterations,
OS.
Studies
were
screened
based
relevance,
language,
topic,
with
71
articles
meeting
inclusion
criteria
after
removing
duplicates.
Results:
findings
reveal
that
OS,
exacerbated
by
iron
overload
regular
blood
transfusions,
is
significantly
associated
impaired
sperm
quality
patients
TM.
Iron
toxicity
gonadotropin
levels,
reduces
quality,
contributes
hypogonadism.
Additionally,
show
promise
reducing
OS-induced
damage,
though
efficacy
limited
lack
robust
clinical
trials.
Conclusions:
plays
considerable
role
infertility
among
primarily
iron-induced
damage
disruptions.
While
may
offer
partial
remedy,
further
research
necessary
understand
OS’s
TM
develop
effective
treatments.
highlights
need
personalized
approaches
improve
reproductive
outcomes
this
population.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(7), С. 3073 - 3073
Опубликована: Март 27, 2025
Erectile
dysfunction
(ED)
is
a
prevalent
condition
affecting
male
sexual
health,
characterized
by
the
inability
to
achieve
or
maintain
satisfactory
erections.
ED
has
multifactorial
pathogenesis
in
which
psychological,
hormonal,
neurologic,
cardiovascular,
and
lifestyle
factors
all
contribute
progressive
decline
of
erectile
function.
A
critical
underlying
mechanism
involves
oxidative
stress
(OS),
an
imbalance
between
reactive
oxygen
species
(ROS)
production
antioxidant
defenses,
disrupts
endothelial
function,
reduces
nitric
oxide
(NO)
bioavailability,
contributes
vascular
dysfunction.
This
narrative
review
explores
interplay
OS
ED,
focusing
on
roles
ROS
sources
such
as
NADPH
oxidase,
xanthine
uncoupled
synthase,
mitochondrial
It
examines
impact
chronic
conditions
like
hypertension,
diabetes
mellitus,
hyperlipidemia,
hypogonadism,
smoking
obesity,
exacerbate
through
systemic
effects.
Emerging
research
underscores
potential
therapies
interventions
restore
redox
balance,
improve
mitigate
ED's
progression.
also
highlights
gaps
understanding
molecular
pathways
linking
emphasizing
need
for
further
develop
targeted
therapeutic
strategies.
Frontiers in Physiology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 12, 2024
Regular
exercise
is
widely
recognized
for
its
numerous
physical
and
mental
benefits,
but
effects
on
male
reproductive
health
are
less
understood.
This
review
aims
to
summarize
the
current
evidence
impact
of
reproduction,
including
hormone
regulation,
spermatogenesis
sperm
quality,
fertility.
Moderate
improves
increasing
count,
motility,
morphology,
while
excessive
severe
may
have
detrimental
effects.
Exercise
positively
influences
fertility
by
reducing
oxidative
stress
enhancing
DNA
integrity.
activity
regulates
hormones,
testosterone,
follicle-stimulating
hormone,
luteinizing
hormone.
Exercise-induced
weight
management
improved
insulin
sensitivity
also
contribute
better
health.
In
conclusion,
has
a
profound
health,
with
moderate
promoting
hormonal
balance,
However,
severe/excessive
exerts
negative
These
findings
imply
that
balanced
routine,
usually
mild
moderate,
combined
healthy
lifestyle
essential
optimal
once
prolonged,
it
could
impair
Further
research
needed
understand
mechanisms
underlying
exercise-reproduction
relationship
fully.
Individual
antioxidants
may
not
fully
capture
the
comprehensive
antioxidant
intake
from
an
individual's
diet.
This
study
utilizes
Complex
Dietary
Antioxidant
Index
(CDAI)
to
evaluate
combined
effects
of
various
dietary
in
The
goal
is
investigate
relationship
between
CDAI
and
incidence
erectile
dysfunction
(ED),
offering
insights
for
guidelines
intervention
strategies
aimed
at
mitigating
burden
ED.
cross-sectional
utilized
data
National
Health
Nutrition
Examination
Survey
(NHANES)
database
years
2001–2004.
We
employed
a
weighted
multivariate
logistic
regression
model
validate
Subgroup
analyses
were
conducted
explore
correlation
ED
across
different
subgroups.
Additionally,
we
used
propensity
score
matching
(PSM)
adjust
several
key
confounding
variables,
enhancing
robustness
results.
In
adjusted
negatively
correlated
with
risk
(OR
=
0.95,
95%
CI:
0.92–0.99,
P
0.005).
When
transformed
into
categorical
variable
based
on
quartiles,
Q3
0.73,
0.53–0.99,
0.040)
Q4
0.70,
0.51–0.96,
0.026)
show
negative
analysis
reveals
no
significant
interaction.
After
adjusting
major
variables
through
PSM,
association
reduced
remains
significant.
our
cohort,
there
ED,
further
research
needed
refine
this
conclusion.
American Journal of Clinical and Experimental Urology,
Год журнала:
2024,
Номер
12(5), С. 226 - 239
Опубликована: Янв. 1, 2024
Long
non-coding
RNAs
(lncRNAs)
primarily
engage
with
mRNA,
DNA,
proteins,
and
microRNAs
(miRNAs),
thereby
regulating
gene
expression;
however,
its
specific
role
in
diabetic
erectile
dysfunction
(DED)
has
not
been
studied.
This
study
aims
to
investigate
the
effects
mechanisms
of
LncRNA
CRYM-AS1
DED.
The
differential
target
was
identified
penile
tissues
rats
DED
through
bioinformatics
analyses.
A
KEGG
signaling
pathway
enrichment
analysis
suggested
a
potential
association
between
Hippo-YAP1
pathway.
Real-time
fluorescent
quantitative
PCR
(RT-qPCR)
results
indicated
significantly
lower
expression
tissue
compared
control
group.
Western
Blot
immunohistochemistry
(IHC)
staining
demonstrated
elevated
protein
levels
YAP1,
Caspase3,
BAX,
Bcl-2,
decreased
Bcl-2/BAX
ratio.
CCK8
cell
viability
showed
significant
decrease
high
glucose
group
at
4
days
modeling,
normal
group,
RT-qPCR
that
human
umbilical
vein
endothelial
cells
(HUVECs)
reduced;
Cleaved-caspase3
BAX
up-regulated,
Bcl-2
down-regulated
Compared
empty
vector
after
transfection
siLncRNA
down-regulated,
mRNA
Cleaved-caspase3,
were
ratio
decreased.
Flow
cytometry
apoptosis
rate
HUVECs
increased
interference.
Low
may
activate
regulate
HUVECs,
leading
ED
development,
discovery
new
genes
provide
therapeutic
targets
disfunction.
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(23), С. 7123 - 7123
Опубликована: Ноя. 25, 2024
:
The
objective
of
this
study
is
to
explore
potential
correlations
between
prostate
volume,
LUTS,
and
IIEF,
with
a
particular
emphasis
on
the
relationship
dimensions-width,
height,
length-and
both
LUTS
IIEF
assess
patients
based
risk
factors
such
as
hypertension,
diabetes,
cardiovascular
disease,
smoking,
alcohol
consumption,
PSA
levels.
Diagnostics,
Год журнала:
2024,
Номер
14(24), С. 2789 - 2789
Опубликована: Дек. 12, 2024
Background/Objectives:
Beta-thalassemia
(BTH),
a
genetic
disorder
resulting
from
beta-globin
gene
mutations,
affects
over
1.5
million
people
globally.
The
disorder’s
multifactorial
impact
on
male
fertility,
particularly
through
oxidative
stress
(OS),
warrants
focused
study.
This
review
examines
the
mechanisms
of
OS
in
TM,
its
implications
for
infertility,
and
potential
antioxidant
therapies
to
mitigate
fertility
challenges.
Methods:
A
non-systematic
was
conducted
using
PubMed,
Cochrane,
Medscape
databases,
focusing
studies
beta-thalassemia
erectile
dysfunction
(ED),
hormonal
alterations,
OS.
Studies
were
screened
based
relevance,
language,
topic,
with
71
articles
meeting
inclusion
criteria
after
removing
duplicates.
Results:
findings
reveal
that
OS,
exacerbated
by
iron
overload
regular
blood
transfusions,
is
significantly
associated
impaired
sperm
quality
patients
TM.
Iron
toxicity
gonadotropin
levels,
reduces
quality,
contributes
hypogonadism.
Additionally,
show
promise
reducing
OS-induced
damage,
though
efficacy
limited
lack
robust
clinical
trials.
Conclusions:
plays
considerable
role
infertility
among
primarily
iron-induced
damage
disruptions.
While
may
offer
partial
remedy,
further
research
necessary
understand
OS’s
TM
develop
effective
treatments.
highlights
need
personalized
approaches
improve
reproductive
outcomes
this
population.
