Streptomyces: Still the Biggest Producer of New Natural Secondary Metabolites, a Current Perspective

Microbiology Research, Год журнала: 2022, Номер 13(3), С. 418 - 465

Опубликована: Июль 1, 2022

There is a real consensus that new antibiotics are urgently needed and the best chance for combating antibiotic resistance. The phylum Actinobacteria one of main producers antibiotics, with recent paradigm shift whereby rare actinomycetes have been increasingly targeted as source secondary metabolites discovery antibiotics. However, this review shows genus Streptomyces still largest current producer innovative metabolites. Between January 2015 December 2020, significantly high number novel spp. isolated from different environments, including extreme symbionts, terrestrial soils, sediments also marine mainly invertebrates sediments. This highlights 135 species during 6-year period 108 environment 27 sources. A brief summary pre-treatment methods used successful isolation some discussed, well biological activities total 279 recorded 121 which exhibit diverse activity. greatest originated terrestrial-sourced

Язык: Английский

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Marine bacteria as source of antimicrobial compounds

Critical Reviews in Biotechnology, Год журнала: 2020, Номер 40(3), С. 306 - 319

Опубликована: Янв. 28, 2020

The marine environment encompasses a huge biological diversity and can be considered as an underexplored location for prospecting bioactive molecules. In this review, the current state of art about antimicrobial molecules from bacteria has been summarized considering main phylum sources evolved in environment. Considering last two decades, we have found most studied group producers substances with activity is Firmicutes phylum, particular strains Bacillus genus. reason that attributed to difficult cultivation typical Actinobacteria sediment, whose members are major land environments. However, reversed trend observed recent years increasing number reports settling on Actinobacteria. Great chemical structures identified, such fijimicyns lynamicyns Actinomycetes macrolactins produced by Bacillus.

Язык: Английский

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Insights into the Cultured Bacterial Fraction of Corals

mSystems, Год журнала: 2021, Номер 6(3)

Опубликована: Июнь 22, 2021

Our paper is the first study to synthesize currently available but decentralized data of cultured microbes associated with corals. We were able collate 3,055 isolates across a number published studies and unpublished collections from various laboratories researchers around world.

Язык: Английский

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Potentials of marine natural products against malaria, leishmaniasis, and trypanosomiasis parasites: a review of recent articles

Infectious Diseases of Poverty, Год журнала: 2021, Номер 10(1)

Опубликована: Янв. 22, 2021

Malaria and neglected communicable protozoa parasitic diseases, such as leishmaniasis, trypanosomiasis, are among the otherwise called diseases for communities, which habitual in underprivileged populations developing tropical subtropical regions of Africa, Asia, Americas. Some currently available therapeutic drugs have some limitations toxicity questionable efficacy long treatment period, encouraged resistance. These prompted many researchers to focus on finding new that safe, effective, affordable from marine environments. The aim this review was show diversity, structural scaffolds, in-vitro or in-vivo efficacy, recent progress made discovery/isolation natural products (MNPs) with potent bioactivity against malaria, trypanosomiasis. We searched PubMed Google scholar using Boolean Operators (AND, OR, NOT) combination related terms articles discovery published only English language January 2016 June 2020. Twenty nine reported isolation, identification antiparasitic activity isolated compounds environment. A total 125 were been isolated, out 45 newly compounds. all bacteria, a fungus, sponges, algae, bryozoan, cnidarians soft corals. In years, great is being anti-malarial drug organisms isolation these Comparably, promising antikinetoplastid MNPs potency better similar conventional could be developed both antileishmanial antitrypanosomal drugs. However, very few pharmaceutical destiny due lack following: sustainable production bioactive compounds, standard efficient screening methods, knowledge mechanism action, partnerships between industries. It crystal clear rich source alkaloids, terpenoids, peptides, polyketides, terpene, coumarins, steroids, fatty acid derivatives, lactones. current future technological innovation will bolster armamentarium malaria diseases.

Язык: Английский

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Jellyfish-Associated Microbiome in the Marine Environment: Exploring Its Biotechnological Potential

Marine Drugs, Год журнала: 2019, Номер 17(2), С. 94 - 94

Опубликована: Фев. 1, 2019

Despite accumulating evidence of the importance jellyfish-associated microbiome to jellyfish, its potential relevance blue biotechnology has only recently been recognized. In this review, we emphasize biotechnological host–microorganism systems and focus on gelatinous zooplankton as a host for with potential. The basic characteristics microbial communities, mechanisms underlying jellyfish-microbe relationship, role/function are reviewed. It appears that is discrete from community in ambient seawater, exhibiting certain degree specialization some preferences specific jellyfish taxa populations, life stages, body parts. addition, different sampling approaches methodologies study phylogenetic diversity described discussed. Finally, general conclusions drawn existing literature future research directions highlighted microbiome.

Язык: Английский

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Dark, rare and inspirational microbial matter in the extremobiosphere: 16 000 m of bioprospecting campaigns

Microbiology, Год журнала: 2019, Номер 165(12), С. 1252 - 1264

Опубликована: Июнь 11, 2019

The rationale of our bioprospecting campaigns is that the extremobiosphere, particularly deep sea and hyper-arid deserts, harbours undiscovered biodiversity likely to express novel chemistry biocatalysts thereby providing opportunities for therapeutic drug industrial process development.We have focused on actinobacteria because their frequent role as keystone species in soil ecosystems unrivalled track record a source bioactive compounds.Population numbers diversity extremobiosphere are traditionally considered be low, although they often comprise dominant bacterial biota.Recent metagenomic evaluation 'the uncultured microbial majority' has now revealed enormous taxonomic among 'dark' 'rare' samples diverse sediments from depths Mariana Trench soils heights Central Andes.The application innovative culture screening options emphasize rigorous dereplication at each stage analysis, strain prioritization identify 'gifted' organisms, been deployed detect characterize hit compounds sought-after catalysts this hitherto untapped resource.The rewards include first-in-a-class chemical entities with modes action, well growing seed bank represents potentially biotechnological innovation.

Язык: Английский

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Bioactive Molecules from Extreme Environments

Marine Drugs, Год журнала: 2020, Номер 18(12), С. 640 - 640

Опубликована: Дек. 14, 2020

Marine organisms inhabiting extreme habitats are a promising reservoir of bioactive compounds for drug discovery. Extreme environments, i.e., polar and hot regions, deep sea, hydrothermal vents, marine areas high pressure or salinity, experience conditions close to the limit life. In these ecosystems, “hot spots” biodiversity, have adopted huge variety strategies cope with such harsh conditions, as production molecules potentially valuable biotechnological applications pharmaceutical, nutraceutical cosmeceutical sectors. Many enzymes isolated from environments may be great interest in detergent, textile, paper food industries. natural products produced by evolved under hostile exhibit wide structural diversity biological activities. fact, they exert antimicrobial, anticancer, antioxidant anti-inflammatory The aim this Special Issue “Bioactive Molecules Environments” was provide most recent findings on well used discovery pipelines pharmaceutical applications, an effort encourage further research habitats.

Язык: Английский

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Natural Products: Implication in Cancer Prevention and Treatment through Modulating Various Biological Activities

Anti-Cancer Agents in Medicinal Chemistry, Год журнала: 2020, Номер 20(17), С. 2025 - 2040

Опубликована: Июль 6, 2020

Cancer is one of the most leading causes death worldwide. It primary global diseases that cause morbidity and mortality in millions people. usually caused by different carcinogenic agents damage genetic material alter cell signaling pathways. Carcinogens are classified into two groups as genotoxic non-genotoxic agents. Genotoxic carcinogens capable directly altering material, while producing cancer some secondary mechanisms not related to direct gene damage. There undoubtedly greatest need utilize novel natural products anticancer agents, these within reach everywhere. Interventions aimed at decreasing levels conditions risk factors can reduce frequency incidences. conventionally treated surgery, radiation therapy chemotherapy, but such treatments may be fast-acting adverse effects on normal tissues. Alternative innovative methods treatment with least side improved efficiency being encouraged. In this review, we discuss development, conventional strategies its management provide a brief review recognized used globally.

Язык: Английский

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Marine Terpenoids from Polar Latitudes and Their Potential Applications in Biotechnology

Marine Drugs, Год журнала: 2020, Номер 18(8), С. 401 - 401

Опубликована: Июль 29, 2020

Polar marine biota have adapted to thrive under one of the ocean’s most inhospitable scenarios, where extremes temperature, light photoperiod and ice disturbance, along with ecological interactions, selected species a unique suite secondary metabolites. Organisms Arctic Antarctic oceans are prolific sources natural products, exhibiting wide structural diversity remarkable bioactivities for human applications. Chemical skeletons belonging terpene families commonly found compounds, whereas cytotoxic antimicrobial properties, capacity prevent infections, widely reported activities from these environments. This review firstly summarizes regulations on access benefit sharing requirements research in polar Then it provides an overview product arsenal organisms that displays promising uses fighting disease. Microbes, such as bacteria fungi, macroorganisms, sponges, macroalgae, ascidians, corals, bryozoans, echinoderms mollusks, main focus this review. The biological origin, structure terpenes terpenoids, derivatives their biotechnological potential described. survey aims highlight chemical life versatility group biomolecules, effort encourage further drug discovery.

Язык: Английский

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Investing in Blue Natural Capital to Secure a Future for the Red Sea Ecosystems

Frontiers in Marine Science, Год журнала: 2021, Номер 7

Опубликована: Янв. 15, 2021

For millennia, coastal and marine ecosystems have adapted flourished in the Red Sea’s unique environment. Surrounded by deserts on all sides, Sea is subjected to high dust inputs receives very little freshwater input, so harbors a salinity. Coral reefs, seagrass meadows, mangroves flourish this environment provide socio-economic environmental benefits bordering coastlines countries. Interestingly, while coral reef are currently experiencing rapid decline global scale, those appear be relatively better shape. That said, they certainly not immune stressors that cause degradation, such as increasing ocean temperature, acidification pollution. In many regions, already severely deteriorating further threatened population pressure large development projects. Degradation of these habitats will lead costs, well significant economic losses. Therefore, it result missed opportunity for countries develop sustainable blue economy integrate innovative nature-based solutions. Recognizing securing ecosystems’ future must occur synergy with continued social growth, we developed an action plan conservation, restoration, growth environments Sea. We then investigated level resources financial investment may incentivize activities. This study presents set commercially viable strategies, ecological innovations, opportunities, which can, if implemented strategically, help ensure long-term promoting conservation. make case investing natural capital propose strategic model relies maintaining health safeguard development.

Язык: Английский

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