Pregnancy and COVID-19: past, present and future DOI Creative Commons
Young Keun Kim, Eui Hyeok Kim

Obstetrics & Gynecology Science, Journal Year: 2023, Volume and Issue: 66(3), P. 149 - 160

Published: March 20, 2023

Current evidence suggests that severe acute respiratory syndrome coronavirus 2 infection is associated with an increased incidence of adverse maternal and perinatal outcomes. However, vertical transmission rare. The management pregnant women disease 2019 (COVID-19) similar to non-pregnant women, effective treatments, including antiviral therapy, dexamethasone, prophylactic anticoagulation should not be withheld during pregnancy.During the early COVID-19 pandemic period, was often delayed until polymerase chain reaction (PCR) results came out or due close contact, even among those without symptoms. Out concern for spread infection, cesarean sections were performed instead vaginal birth, since could have led increase in neonatal morbidities. Additionally, if PCR test positive, neonate quarantined, despite infectivity decreasing 10 days after symptom onset. It necessary ease strict measures control field obstetrics.The presence absence symptoms identified stratify risk, delivery can attempted asymptomatic low infectivity. With more being vaccinated safety data about vaccination rapidly accumulating no concerns been detected. Globally, vaccines are recommended pregnancy. In order prepare future pandemics, it apply lessons learned from this pandemic. Policymakers healthcare leaders must determine efficient strategies preserving safe care, ongoing global emergency.

Language: Английский

Fetal and placental infection with SARS‐CoV‐2 in early pregnancy DOI Open Access
María Yolotzin Valdespino-Vázquez, Addy Cecilia Helguera‐Repetto, Moisés León‐Juárez

et al.

Journal of Medical Virology, Journal Year: 2021, Volume and Issue: 93(7), P. 4480 - 4487

Published: March 25, 2021

Abstract To date, mother‐to‐fetus transmission of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), responsible for the disease 2019 (COVID‐19) pandemic, remains controversial. Although placental COVID‐19 infection has been documented in some cases during second‐ and third‐trimesters, no reports are available first trimester pregnancy, SARS‐CoV‐2 protein found fetal tissues. We studied placenta organs from an early pregnancy miscarriage a maternal by immunohistochemical, reverse transcription quantitative real‐time polymerase chain reaction, immunofluorescence, electron microscopy methods. nucleocapsid protein, viral RNA, particles consistent with were tissues, accompanied RNA replication revealed double‐stranded (dsRNA) positive immunostain. Prominent damage associated hyperinflammatory process identified histological examination immunohistochemistry. The findings provided this study document that congenital is possible organs, such as lung kidney, targets coronavirus. multi‐organic inflammation produced should alert clinicians assessment management pregnant women consequences adverse perinatal outcomes.

Language: Английский

Citations

72
Neonates and COVID-19: state of the art DOI Open Access
Lucy Ryan, Frans B. Plötz, Agnes van den Hoogen

et al.

Pediatric Research, Journal Year: 2021, Volume and Issue: 91(2), P. 432 - 439

Published: Dec. 28, 2021

Language: Английский

Citations

72
COVID-19 and pregnancy: clinical outcomes; mechanisms, and vaccine efficacy DOI Creative Commons
Deepak Kumar, Sonam Verma, Indira U. Mysorekar

et al.

Translational research, Journal Year: 2022, Volume and Issue: 251, P. 84 - 95

Published: Aug. 12, 2022

Language: Английский

Citations

50
SARS-COV2 placentitis and pregnancy outcome: A multicentre experience during the Alpha and early Delta waves of coronavirus pandemic in England DOI Creative Commons

Sophie Stenton,

Jo McPartland,

Rajeev Shukla

et al.

EClinicalMedicine, Journal Year: 2022, Volume and Issue: 47, P. 101389 - 101389

Published: April 15, 2022

Language: Английский

Citations

48
The impact of COVID-19 on pregnancy outcomes in a diverse cohort in England DOI Creative Commons
M. Wilkinson, Edward Johnstone, Louise Simcox

et al.

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: Jan. 18, 2022

There is conflicting evidence regarding the effect of coronavirus disease (COVID-19) in pregnancy. Risk factors for COVID-19 overlap with risk pregnancy complications. We aimed to assess effects pandemic and confirmed SARS-CoV-2 infection on outcomes. A retrospective interrupted time-series matched cohort analysis was performed. Singleton pregnancies completed between 1st January 2016 31st 2021 were included. Trends outcomes analysed over time. Modelled transmission data applied deliveries since 2020 assign a each pregnancy, incorporated into regression model birthweight. Confirmed cases controls delivered pre-pandemic period, maternal neonatal compared. 43,802 included, 8343 no increase stillbirth (p = 0.26) or death 0.64) during pandemic. association modelled attack rate (%) any trimester birthweight (first p 0.50, second 0.15, third 0.16). 214 COVID-positive women controls. Preterm birth more common symptomatic (14/62, 22.6%) compared asymptomatic (9/109, 8.3%, 0.008) (5/62, 8.1%, 0.025). Iatrogenic preterm (21/214, 9.8%) than (9/214, 4.2%, 0.02). All other examined similar groups. significant impact available. Symptomatic should be considered factor birth, possibly due an iatrogenic indications.

Language: Английский

Citations

40
Meta-analysis on COVID-19-pregnancy-related placental pathologies shows no specific pattern DOI Open Access
Jan-Theile Suhren,

Andre Meinardus,

Kais Hussein

et al.

Placenta, Journal Year: 2021, Volume and Issue: 117, P. 72 - 77

Published: Oct. 21, 2021

Language: Английский

Citations

50
Case Report: Neonatal Multi-System Inflammatory Syndrome Associated With SARS-CoV-2 Exposure in Two Cases From Saudi Arabia DOI Creative Commons
Lana A. Shaiba,

Adnan Hadid,

Khalid A Altirkawi

et al.

Frontiers in Pediatrics, Journal Year: 2021, Volume and Issue: 9

Published: May 13, 2021

Background: Vertical transmission of SARS-CoV-2 is under investigation. A few reports suggest the possibility from mothers to their neonates. Most neonates have mild symptoms, but some develop multisystem involvement and shock. Case Presentation: We report two cases possible vertical The first case shows maternal infection with in second trimester followed by recurrent third right before delivery. infant demonstrated respiratory distress soon after delivery along myocardial dysfunction multi-organ system involvement. SARS-COV-2 at time preterm labor secondary placental abruption, that resulting neonate requiring non-invasive ventilation context persistently positive PCR neonate. Both were treated IVIG steroids. recovered fully discharged allowed go home. Conclusion: In neonates, COVID-19 usually presents as an asymptomatic or illness; may a more severe course. Our cases, however, demonstrate involvement, although rare, possible. This also supports current evidence might be underreported should considered when born suffering COVID-19. Clinical Trial Registration: [KSUMC], identifier [No#98763298].

Language: Английский

Citations

44
Severe placental lesions due to maternal SARS-CoV-2 infection associated to intrauterine fetal death DOI
Charlotte Dubucs, Marion Groussolles,

Jessie Ousselin

et al.

Human Pathology, Journal Year: 2022, Volume and Issue: 121, P. 46 - 55

Published: Jan. 5, 2022

Language: Английский

Citations

39
Infants prenatally exposed to SARS-CoV-2 show the absence of fidgety movements and are at higher risk for neurological disorders: A comparative study DOI Creative Commons
Vania Aldrete–Cortez,

Liliana Bobadilla,

Silvia A. Tafoya

et al.

PLoS ONE, Journal Year: 2022, Volume and Issue: 17(5), P. e0267575 - e0267575

Published: May 4, 2022

Congenital viral infections are believed to damage the developing neonatal brain. However, whether neonates exposed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) show manifestations of such remains unclear. For neurodevelopment evaluation, general movement assessments have been shown be effective in identifying early indicators neurological dysfunction, including absence fidgety movements. This study compared motor repertoire by assessment at three five months age who were or not prenatally SARS-CoV-2 determine infants risk disorders. Fifty-six infants, 28 group mothers without vaccination had no need for intensive care and likely infection close time pregnancy resolution nonexposed group, videotaped compare their detailed repertoires, which a optimality score-revised (MOS-R) was calculated using Prechtl's method chi-square Mann-Whitney U tests. In 3 (11%) showed movements with total MOS-R<14 points, other abnormal Between groups, atypical body symmetry (p = 0.009) MOS-R values significantly lower (Z -3.08, p 0.002), large size effect (Cohen's d 0.97). The consequences this new virus go beyond health pregnant mother, these some transitory because between 3-5 months; thus, babies increased serious disorder.

Language: Английский

Citations

37
Analysis of placental pathology after COVID-19 by timing and severity of infection DOI Creative Commons

Chiara M. Corbetta-Rastelli,

Marie Altendahl,

Cynthia Gasper

et al.

American Journal of Obstetrics & Gynecology MFM, Journal Year: 2023, Volume and Issue: 5(7), P. 100981 - 100981

Published: April 23, 2023

COVID-19 during pregnancy can have serious effects on outcomes. The placenta acts as an infection barrier to the fetus and may mediate adverse Increased frequency of maternal vascular malperfusion has been detected in placentas patients with compared controls, but little is known about how timing severity affect placental pathology.

Language: Английский

Citations

22