Prognostic Nutritional Index, Controlling Nutritional Status (CONUT) Score, and Inflammatory Biomarkers as Predictors of Deep Vein Thrombosis, Acute Pulmonary Embolism, and Mortality in COVID-19 Patients

Diagnostics, Год журнала: 2022, Номер 12(11), С. 2757 - 2757

Опубликована: Ноя. 11, 2022

Background: Numerous tools, including nutritional and inflammatory markers, have been evaluated as the predictors of poor outcomes in COVID-19 patients. This study aims to verify predictive role prognostic index (PNI), CONUT Score, markers (monocyte lymphocyte ratio (MLR), neutrophil (NLR), platelet (PLR), systemic (SII), Systemic Inflammation Response Index (SIRI), Aggregate (AISI)) cases deep vein thrombosis (DVT) acute pulmonary embolism (APE) risk, well mortality, Methods: The present was designed an observational, analytical, retrospective cohort study, included 899 patients over age 18 who had a infection, confirmed through real time-polymerase chain reaction (RT-PCR), were admitted County Emergency Clinical Hospital Modular Intensive Care Unit UMFST “George Emil Palade” Targu Mures, Romania between January 2020 March 20212. Results: Non-Surviving associated with higher incidence chronic kidney disease (p = 0.01), cardiovascular (atrial fibrillation (AF) p 0.01; myocardial infarction (MI) 0.02; peripheral arterial (PAD) 0.0003), malignancy 0.0001), tobacco obesity dyslipidemia 0.004), malnutrition < 0.0001). Multivariate analysis showed that both high baseline value all independent adverse for enrolled (for presence PAD, malignancy, tobacco, also outcomes. Conclusions: According our findings, MLR, NLR, PLR, SII, SIRI, AISI, lower PNI values at admission strongly predict DVT APE mortality Moreover, predicted outcomes, while CKD predicts risk but not risk.

Язык: Английский

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Systemic inflammation index, disease severity, and mortality in patients with COVID-19: a systematic review and meta-analysis

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Июнь 21, 2023

Introduction An excessive systemic pro-inflammatory state increases the risk of severe disease and mortality in patients with coronavirus 2019 (COVID-19). However, there is uncertainty regarding whether specific biomarkers inflammation can enhance stratification this group. We conducted a systematic review meta-analysis to investigate an emerging biomarker derived from routine hematological parameters, index (SII), COVID-19 different severity survival status. Methods A literature search was PubMed, Web Science, Scopus, between 1 st December 15 th March 2023. Risk bias certainty evidence were assessed using Joanna Briggs Institute Critical Appraisal Checklist Grades Recommendation, Assessment, Development Evaluation, respectively (PROSPERO registration number: CRD42023420517). Results In 39 studies, or non-survivor status had significantly higher SII values on admission compared non-severe survivor (standard mean difference (SMD)=0.91, 95% CI 0.75 1.06, p&lt;0.001; moderate evidence). The also associated death 10 studies reporting odds ratios (1.007, 1.001 1.014, p=0.032; very low evidence) six hazard (1.99, 1.01 3.92, p=0.047; Pooled sensitivity, specificity, area under curve for 0.71 (95% 0.67 0.75), 0.64 0.77), 0.77 0.73 0.80), respectively. meta-regression, significant correlations observed SMD albumin, lactate dehydrogenase, creatinine, D-dimer. Discussion Our has shown that COVID-19. Therefore, inflammatory haematological parameters be helpful early Systematic https://www.crd.york.ac.uk/PROSPERO , identifier CRD42023420517.

Язык: Английский

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Inflammatory Biomarkers as Prognostic Factors of Acute Deep Vein Thrombosis Following the Total Knee Arthroplasty

Medicina, Год журнала: 2022, Номер 58(10), С. 1502 - 1502

Опубликована: Окт. 21, 2022

Background and objectives: Deep vein thrombosis (DVT) is one of the most serious post-operative complications in case total knee arthroplasty (TKA). This study aims to verify predictive role inflammatory biomarkers [monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte (NLR), platelets-to-lymphocyte (PLR), systemic index (SII), inflammation response (SIRI), aggregate (AISI)] acute DVT following TKA. Materials methods: The present was designed as an observational, analytical, retrospective cohort included all patients over 18 years age with surgical indications for TKA, admitted Department Orthopedics, Regina Maria Health Network, Targu Mures, Romania, Humanitas MedLife Hospital, Cluj-Napoca, Romania between January 2017 July 2022. primary endpoint risk secondary length hospital stay, outcomes were stratified baseline’s optimal MLR, NLR, PLR, SII, SIRI, AISI cut-off value. Results: associated higher (p = 0.01), incidence cardiac disease [arterial hypertension 0.02), atrial fibrillation 0.01)], malignancy 0.005), well factors [smoking 0.03) obesity 0.02)]. Multivariate analysis showed a high baseline value hematological ratios: MLR (OR: 11.06; p < 0.001), NLR 10.15; PLR 12.31; SII 18.87; SIRI 10.86; 14.05; 0.001) independent predictor after TKA recruited patients. Moreover, above 70 2.96; 0.007), AH 2.93; AF 2.71; 3.98; 0.002), 2.34; 0.04), tobacco 2.30; 0.04) predictors risk. Conclusions: Higher pre-operative ratios values determined before operations strongly predict 70, malignancy, cardiovascular disease, such DVT.

Язык: Английский

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Carotid Plaque Features and Inflammatory Biomarkers as Predictors of Restenosis and Mortality Following Carotid Endarterectomy

International Journal of Environmental Research and Public Health, Год журнала: 2022, Номер 19(21), С. 13934 - 13934

Опубликована: Окт. 26, 2022

Carotid endarterectomy (CEA) is the first-line surgical intervention for cases of severe carotid stenoses. Unfortunately, restenosis rate high after CEA. This study aims to demonstrate predictive role plaque features and inflammatory biomarkers (monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR), systemic index (SII), Systemic Inflammation Response Index (SIRI), Aggregate (AISI)) in mortality at 12 months following CEA.The present was designed as an observational, analytical, retrospective cohort included all patients over 18 years age with a minimum 70% stenosis indications CEA admitted Vascular Surgery Clinic, Emergency County Hospital Targu Mures, Romania between 2018 2021.According our results, pre-operative values biomarkers-MLR (OR: 10.37 OR: 6.11; p < 0.001), NLR 34.22 37.62; PLR 12.02 16.06; SII 18.11 31.70; SIRI 16.64 9.89; AISI 16.80 8.24; 0.001)-are strong independent factors predicting risk 12-month Moreover, unstable 2.83, 0.001 2.40, = 0.04) MI 3.16, 0.005) were predictors outcomes. Furthermore, AH 2.30; 0.006), AF 1.74; 0.02), tobacco 2.25; obesity 1.90; thrombotic plaques 2.77; 0.001) restenosis, but not patients. In contrast, antiplatelet 0.46; 0.004), statin 0.59; 0.04), ezetimibe (OR:0.45; 0.03) therapy protective against mortality.Our data revealed that higher preoperative biomarker highly predict above 70, plaque, cardiovascular disease, dyslipidemia Additionally, AH, AF, smoking, Antiplatelet medication, on other hand, mortality.

Язык: Английский

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Brain autopsies of critically ill COVID-19 patients demonstrate heterogeneous profile of acute vascular injury, inflammation and age-linked chronic brain diseases

Acta Neuropathologica Communications, Год журнала: 2022, Номер 10(1)

Опубликована: Дек. 17, 2022

This study examined neuropathological findings of patients who died following hospitalization in an intensive care unit with SARS-CoV-2.

Язык: Английский

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Prognostic Role of Monocyte Distribution Width, CRP, Procalcitonin and Lactate as Sepsis Biomarkers in Critically Ill COVID-19 Patients

Journal of Clinical Medicine, Год журнала: 2023, Номер 12(3), С. 1197 - 1197

Опубликована: Фев. 2, 2023

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a global pandemic and one group of patients has developed form COVID-19 pneumonia with an urgent need for hospitalization intensive care unit (ICU) admission. aim our study was to evaluate the prognostic role MDW, CRP, procalcitonin (PCT), lactate in critically ill patients. primary outcome interest is 28 day mortality ICU confirmed SARS-CoV-2 infection sepsis (according Sepsis 3 criteria change SOFA score ≥ points). Patients were divided into two groups according survival on 28th after admission ICU. Every subgroups (women men). Nonparametric tests (Mann-Whitney) variables age, PCT, lactate, MDW lower than alpha p < 0.05, so there significant difference between survived deceased Chi-square test statistically higher values non-survivor group. We found association procalcitonin, fatal outcome, reported

Язык: Английский

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Systemic immune inflammation index with all-cause and cause-specific mortality: a meta-analysis

Inflammation Research, Год журнала: 2024, Номер 73(12), С. 2199 - 2216

Опубликована: Окт. 14, 2024

Язык: Английский

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Laboratory Findings and Clinical Outcomes of ICU-admitted COVID-19 Patients: A Retrospective Assessment of Particularities Identified among Romanian Minorities

Journal of Personalized Medicine, Год журнала: 2023, Номер 13(2), С. 195 - 195

Опубликована: Янв. 21, 2023

The Roma population accounts for over 3% (approximately 10 to 15 million) of Romania's permanent population, and it represents one Europe's most impoverished populations. Due poverty unemployment, minority may have diminished access healthcare preventive medicine. limited existing evidence suggests that the European group has been at a higher risk becoming ill dying during pandemic owing their lifestyle choices, socioeconomic circumstances, genetic pathophysiological traits. As result, purpose present research was investigate link between inflammatory markers implicated clinical progression COVID-19 in patients who were brought intensive care unit. We considered 71 admitted ICU with SARS-CoV-2 infection 213 controls from general same inclusion criteria. body mass index statistically significantly among patients, more than 57% being overweight, compared 40.7% control group. Frequent smoking prevalent ethnicity number comorbidities. observed proportion severe imaging features admission cases, although this difference associated prevalence mean duration hospitalization longer by 1.8 days Elevated ESR levels 54.0% admission, 38.9% Similarly, 47.6% them had elevated CRP levels. IL-6 increased time similarly significant rise levels, population. However, intubated mortality did not differ significantly. On multivariate analysis, influenced (β = 1.93, p-value 0.020) 1.85, 0.044). It is necessary plan different strategies aimed special populations, such as ethnicity, prevent reduced disparities presented study.

Язык: Английский

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A Real Pandora’s Box in Pandemic Times: A Narrative Review on the Acute Cardiac Injury Due to COVID-19

Life, Год журнала: 2022, Номер 12(7), С. 1085 - 1085

Опубликована: Июль 20, 2022

The intricate relationship between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the cardiovascular system is an extensively studied pandemic topic, as there ever-increasing amount of evidence that reports a high prevalence cardiac injury in context viral infection. In patients with Coronavirus disease 2019, COVID-19, significant increase serum levels troponin or other various biomarkers was observed, suggesting injury, thus predicting both course poor outcome. Pathogenesis not yet completely elucidated, though several mechanisms are allegedly involved, such direct cardiomyocyte oxygen supply-demand inequity caused by hypoxia, active myocardial depressant factors during sepsis, endothelial dysfunction due to hyperinflammatory status. Moreover, increased plasma cytokines catecholamines significantly enhanced prothrombotic environment may lead destabilization rupture atheroma plaques, subsequently triggering coronary syndrome. present review, we focus on describing epidemiology, pathogenesis, role diagnosis prognosis setting COVID-19 pandemic. We also explore some novel therapeutic strategies involving immunomodulatory therapy, well their preventing form disease, short-term outcome long-term sequelae being equally important SARS-CoV-2 induced injury.

Язык: Английский

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Identifying Mortality Predictors in Hospitalized COVID-19 Patients: Insights from a Single-Center Retrospective Study at a University Hospital

Microorganisms, Год журнала: 2024, Номер 12(5), С. 1032 - 1032

Опубликована: Май 20, 2024

Introduction: The pandemic instigated by the SARS-CoV-2 virus has led to over 7 million deaths globally, primarily attributable viral pneumonia. Identifying fundamental markers associated with an elevated risk of mortality can aid in early identification patients prone disease progression a severe state, enabling prompt intervention. Methods: This was single-center, retrospective study. Results: In this study, we examined 299 admitted Department Infectology and Travel Medicine Košice, Slovakia, PCR-confirmed COVID-19 Patients were monitored from 1 January 2021 31 March 2021, endpoint being discharge hospital or death. All patient-related data retrospectively collected medical records. study identified several factors significantly increased mortality, including requirement HFNO (p < 0.001), age 60 years Ne/Ly values >6 as well certain lymphocyte subtypes—CD4+ 0.2 × 109/L = 0.035), CD8+ CD19+ 0.1 0.001)—alongside selected biochemical inflammatory markers—IL-6 > 50 ng/L 0.001) lactate 3 mmol/L 0.001). Conclusions: We confirmed that mentioned death pneumonia hospital.

Язык: Английский

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