Unraveling the clinical significance and prognostic value of the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, systemic immune-inflammation index, systemic inflammation response index, and delta neutrophil index: An extensive literature review

Turkish Journal of Emergency Medicine, Год журнала: 2024, Номер 24(1), С. 8 - 19

Опубликована: Янв. 1, 2024

In the field of critical care medicine, substantial research efforts have focused on identifying high-risk patient groups. This has led to development diverse diagnostic tools, ranging from basic biomarkers complex indexes and predictive algorithms that integrate multiple methods. Given ever-evolving landscape driven by rapid advancements, changing treatment strategies, emerging diseases, validation tools remains an ongoing dynamic process. Specific changes in complete blood count components, such as neutrophils, lymphocytes, monocytes, platelets, are key immune system responses influenced various factors crucial systemic inflammation, injury, stress. It been reported indices neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), immune-inflammation index (SII), inflammation response (SIRI), delta neutrophil calculated using ratios these elements, important predictors outcomes conditions where inflammatory process is at forefront. this narrative review, we concluded NLR, PLR, SII, SIRI show promise predicting for different health related inflammation. While tests accessible, reliable, cost-effective, their standalone performance a specific condition limited.

Язык: Английский

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The diagnostic role of the systemic inflammation index in patients with immunological diseases: a systematic review and meta-analysis

Clinical and Experimental Medicine, Год журнала: 2024, Номер 24(1)

Опубликована: Янв. 29, 2024

Abstract The identification of novel, easily measurable biomarkers inflammation might enhance the diagnosis and management immunological diseases (IDs). We conducted a systematic review meta-analysis to investigate an emerging biomarker derived from full blood count, systemic index (SII), in patients with IDs healthy controls. searched Scopus, PubMed, Web Science inception 12 December 2023 for relevant articles evaluated risk bias certainty evidence using Joanna Briggs Checklist Grades Recommendation, Assessment, Development, Evaluation Working Group system, respectively. In 16 eligible studies, had significantly higher SII when compared controls (standard mean difference, SMD = 1.08, 95% CI 0.75 1.41, p < 0.001; I 2 96.2%, moderate evidence). pooled area under curve (AUC) diagnostic accuracy was 0.85 (95% 0.82–0.88). subgroup analysis, effect size significant across different types ID, barring lupus erythematosus ( 0.20). further analyses, ID active disease vs. those remission (SMD 0.81, 0.34–1.27, 93.6%, AUC 0.74 0.70–0.78). Our study suggests that can effectively discriminate between subjects without disease. Prospective studies are warranted determine whether routine practice. (PROSPERO registration number: CRD42023493142).

Язык: Английский

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Depression heightened the association of the systemic immune-inflammation index with all-cause mortality among osteoarthritis patient

Journal of Affective Disorders, Год журнала: 2024, Номер 355, С. 239 - 246

Опубликована: Март 27, 2024

Язык: Английский

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Unraveling the Impact of COVID-19 on Rheumatoid Arthritis: Insights from Two Romanian Hospitals—Preliminary Results

Biomedicines, Год журнала: 2024, Номер 12(9), С. 2145 - 2145

Опубликована: Сен. 21, 2024

Rheumatoid arthritis (RA) patients are at heightened risk of Coronavirus Disease-19 (COVID-19) complications due to immune dysregulation, chronic inflammation, and treatment with immunosuppressive therapies. This study aims characterize the clinical laboratory parameters RA diagnosed COVID-19, identify predictive factors for severe forms this infection patients, determine if any therapy is associated worse COVID-19 outcomes.

Язык: Английский

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Association of pan-immune inflammation value and lung health in adults

BMC Pulmonary Medicine, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 14, 2025

Lung health is intricately linked with inflammation. The pan-immune-inflammation value (PIV) emerges as a promising biomarker, offering reflection into systemic inflammatory states and assisting in the prognosis of diverse diseases. This research aims to explore associations between PIV respiratory symptoms, diseases lung function. study was cross-sectional population from National Health Nutrition Examination Survey (NHANES). Restricted cubic spline (RCS) models were conducted relationships outcomes, while weighted linear regression logistic ones used for analysis. Trend tests probed evolving relationship among quartiles outcomes. incorporated subgroup analysis interaction examine within specific subpopulations. From cohort 6,263 participants, distinct negative correlation identified health. Subsequent confounding factors, 100-unit increment 2% increase incidence cough phlegm (OR, 95% CI: 1.02, 1.00 1.05; 1.04). Additionally, higher associated reductions FEV1 (MD, -5.37, -9.10 -1.64) FVC -5.75, -10.34 -1.15). Categorizing revealed an ascending trend: A significantly risk cough/phlegm/wheeze found participants second/third/fourth quartile compared those first (all p trend < 0.05). Moreover, function indicators (FEV1, FEV1%, FVC, FVC%, FEV1/FVC) declined fourth Besides, nonlinear outcomes evident. Subgroup variations these stratified by gender, age, smoking drinking status, well certain disease history. highlighted potential connections Monitoring level could provide valuable insights status may inform clinical approaches managing

Язык: Английский

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Predictive Value of First‐Trimester Aggregate Index of Systemic Inflammation (AISI) and Other Inflammatory Indices for Gestational Diabetes Mellitus and Associated Obstetric Outcomes

American Journal of Reproductive Immunology, Год журнала: 2025, Номер 93(4)

Опубликована: Апрель 1, 2025

To investigate the value of first-trimester aggregate index systemic inflammation (AISI) and other combined inflammatory markers in prediction gestational diabetes mellitus (GDM) related obstetric outcomes. The data pregnant women diagnosed with GDM between September 2021 November 2024, as well an equal number control patients, were retrospectively analyzed. patients' AISI, neutrophil lymphocyte ratio (NLR), immune-inflammatory (SII), response (SIRI) values calculated from hemogram parameters participants at 11-14 weeks gestation. clinical characteristics, laboratory results, indices, outcomes, need for neonatal intensive care unit (NICU) admission, presence composite adverse perinatal outcome (CAPO) groups then compared. Receiver operating characteristic (ROC) curve analyses performed to indices that reached statistical significance predicting GDM. group exhibited significantly higher SII AISI values, rate NICU CAPO compared (p = 0.036, p 0.011, < 0.01, respectively). age birth was lower group, while weight ROC yielded area under (AUC) 0.566 0.581 prediction, respectively 0.036 First-trimester may be useful identifying pregnancies high risk developing

Язык: Английский

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Comparative Insights into COVID-19 and Tuberculosis: Clinical Manifestations, Inflammatory Markers, and Outcomes in Pulmonary Versus Extrapulmonary Tuberculosis and SARS-CoV-2 Co-Infection

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(8), С. 2782 - 2782

Опубликована: Апрель 17, 2025

Background: Tuberculosis and COVID-19 co-infection poses significant clinical challenges, with pulmonary TB (PTB) extrapulmonary (extraPTB) potentially influencing disease progression outcomes differently. This study aims to compare the manifestations, inflammatory markers, between PTB extraPTB patients SARS-CoV-2 co-infection. Methods: A retrospective, cross-sectional was conducted on 55 hospitalized adults TB-COVID-19 from March 2020 2022. Patients were divided into (n = 32) 23) groups. Demographic, clinical, laboratory, imaging data collected analyzed using statistical models, including ANCOVA, LASSO regression, Random Forest classification, identify key predictors of hospitalization duration mortality. Results: had significantly lower BMI, worse oxygenation status, greater lung involvement CT compared patients. CRP elevated in PTB, while IL-6 levels higher extraPTB. Hospitalization primarily influenced by coagulation markers (IL-6, D-dimer, neutrophil count, systemic index), BMI associated shorter stays. Mortality risk strongly correlated impairment (worst SpO2, SpO2 at diagnosis), burden (CRP, LDH), severity score, rather than localization. Conclusions: localization did not independently affect or mortality risk. Instead, severe involvement, inflammation, hypoxemia strongest poor outcomes. These findings emphasize importance early stratification based respiratory optimize patient management. Further research is needed clarify long-term impact co-infection, particularly cases.

Язык: Английский

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Systemic immune-inflammation index and its relation to blood pressure and dyslipidemia in adults: A retrospective study

Medicine, Год журнала: 2024, Номер 103(28), С. e38810 - e38810

Опубликована: Июль 12, 2024

High blood pressure (BP) and dyslipidemia are major risk factors for cardiovascular disease mortality. The systemic immune-inflammation index (SII) has been suggested as a predictive tool to identify those at chronic diseases, however, its use predicting high BP not thoroughly investigated. This study aimed examine the association between SII well lipid markers. Retrospective hospital data from large cohort (n = 3895) of Saudi adults aged ≥18 years were analyzed. Lipid markers (cholesterol, high-density lipoprotein, low-density lipoprotein [LDL]), systolic BP, diastolic measures extracted. When sample was divided into quartiles SII, cholesterol, triglycerides, LDL higher in with than lower ( P < .01). After adjusting potential confounders, significantly associated odds hypertension (odds ratio: 1.12, 95% confidence interval: 1.04–1.21) elevated 1.07, CI: 1.02–1.14), but cholesterol. Across there significant trend people diabetes ≥65 years. could be an economical measure identifying individuals some aspects dyslipidemia. Longitudinal studies needed confirm this relationship.

Язык: Английский

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A Comparative Study of the Aggregate Index of Systemic Inflammation (AISI) and C-Reactive Protein (CRP) in Predicting Odontogenic Abscesses Severity: A Novel Approach to Assessing Immunoinflammatory Response

Diagnostics, Год журнала: 2024, Номер 14(19), С. 2163 - 2163

Опубликована: Сен. 28, 2024

Background/Objectives: Odontogenic abscesses are a common cause of emergency visits to oral and maxillofacial surgery departments can lead life-threatening complications if they not recognized treated promptly. The aim this study was evaluate the prognostic value Aggregate Index Systemic Inflammation (AISI) in comparison other systemic inflammatory indices, including Immune (SII), Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte (PLR), Lymphocyte-to-Monocyte (LMR), predicting severity odontogenic abscesses. Methods: This retrospective included 221 patients hospitalized for at Dubrava University Hospital between January 2019 December 2023. Clinical laboratory data, AISI, SII, NLR, PLR, LMR, were collected. assessed using Symptom Severity (SS) Score categorized into less severe groups based on their scores. An ROC curve analysis used assess predictive accuracy each index. Results: AISI identified as most effective predictor abscess had highest sensitivity (SE = 82.93) specificity (SP 81.63) among indices analyzed. It outperformed C-reactive protein (CRP) with an AUC 0.90 compared 0.74 CRP. In addition, showed significant correlations length hospital stay occurrence response syndrome (SIRS). Conclusions: index is better markers Its integration clinical practice could improve early detection high-risk patients, leading treatment outcomes lower risks complications.

Язык: Английский

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Colliding Challenges: An Analysis of SARS-CoV-2 Infection in Patients with Pulmonary Tuberculosis versus SARS-CoV-2 Infection Alone

Medicina, Год журнала: 2024, Номер 60(5), С. 823 - 823

Опубликована: Май 16, 2024

: The concurrent occurrence of tuberculosis and COVID-19 coinfection poses significant clinical complexities, warranting a nuanced approach to diagnosis, management, patient care.

Язык: Английский

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